22136-1-AP

antibody from Proteintech Group

Targeting: TIGAR C12orf5

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

22136-1-AP

Provider

Proteintech Group

Product name

TIGAR antibody

Antibody type

Polyclonal

Description

TIGAR antibody (Cat. #22136-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB, ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

TIGAR maintains intestinal epithelial regeneration by stabilizing HMGCL and promoting β-catenin β-hydroxybutyrylation in burn-induced sepsis.

Zhang P, Wu D, Wei Y, Su S, Zha X, Liu X, Zhang T, Huang Q, Chen Q, Bao Z, Fan S, Xia L, Peng X
Cell death & disease 2026 Feb 19;17(1)

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p53 and TIGAR promote redox control to protect against metabolic dysfunction-associated steatohepatitis.

Wittke CI, Cheung EC, Athineos D, Clements N, Butler L, Hughes M, Morrison V, Watt DM, Blyth K, Vousden KH, Humpton TJ
JHEP reports : innovation in hepatology 2025 Jul;7(7):101397

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TIGAR regulated by HPV E6 is correlated with disease stage, drug sensitivity, and immune microenvironment in cervical cancer.

Liu Y, Zhang Y, Zhang H, Xu D, Zhou X, Xie L, Xi H, Zhu Y, Yang H, Zhu X, Ren J, Min S, Tan Y
Scientific reports 2025 Jul 1;15(1):20618

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Divergent sex-specific effects on a ketogenic diet: Male, but not female, mice exhibit oxidative stress and cellular senescence.

Wei SJ, Schell J, Qian W, Silguero M, Baseviciene A, Chen WH, Trevino R Jr, Chocron ES, Ogle MM, Varmazyad M, Martinez GM, Cruz D, Lorenzana B, Dong FF, Jiang H, Nazarullah A, Beardsley RA, Sharma K, Chang J, Munkácsy E, Horikoshi N, Gius D
Cell reports 2025 Aug 26;44(8):116026

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Dual targeting of wild-type p53 and gut microbiota by Magnolol represses key metabolic process and kills CRC cells.

Ji H, Qiao O, Zhang Y, Wang W, Han X, Zhang X, Liu C, Gao W
Phytotherapy research : PTR 2024 Oct;38(10):4982-4998

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Impact of TP53-induced glycolysis and apoptosis regulator on malignant activity and resistance to ferroptosis in intrahepatic cholangiocarcinoma.

Toshida K, Itoh S, Iseda N, Izumi T, Yoshiya S, Toshima T, Ninomiya M, Iwasaki T, Oda Y, Yoshizumi T
Cancer science 2024 Jan;115(1):170-183

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TIGAR exacerbates obesity by triggering LRRK2-mediated defects in macroautophagy and chaperone-mediated autophagy in adipocytes.

Zhang T, Linghu KG, Tan J, Wang M, Chen D, Shen Y, Wu J, Shi M, Zhou Y, Tang L, Liu L, Qin ZH, Guo B
Autophagy 2024 Aug;20(8):1741-1761

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Oxidative stress-induced alterations in retinal glucose metabolism in Retinitis Pigmentosa.

Kanan Y, Hackett SF, Taneja K, Khan M, Campochiaro PA
Free radical biology & medicine 2022 Mar;181:143-153

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Maternal Herpesviridae infection during pregnancy alters midbrain dopaminergic signatures in adult offspring.

Burmeister AR, Gordevicius J, Paul EN, Houck C, George S, Escobar Galvis ML, Sha Q, Brundin P, Pospisilik JA, Racicot K, Brundin L
Neurobiology of disease 2022 Jul;169:105720

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MiR-652-5p elevated glycolysis level by targeting TIGAR in T-cell acute lymphoblastic leukemia.

Liu S, Wang H, Guo W, Zhou X, Shu Y, Liu H, Yang L, Tang S, Su H, Liu Z, Zeng L, Zou L
Cell death & disease 2022 Feb 14;13(2):148

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Cordycepin exhibits anti-fatigue effect via activating TIGAR/SIRT1/PGC-1α signaling pathway.

Chai X, Pan M, Wang J, Feng M, Wang Y, Zhang Q, Sun Y
Biochemical and biophysical research communications 2022 Dec 31;637:127-135