307201

antibody from BioLegend

Targeting: DYRK4

Flow cytometry (Supportive data in Antibodypedia)

Antibody Data

Product number

307201

Provider

BioLegend

Proper citation

BioLegend Cat#307201, RRID:AB_314665

Product name

Purified anti-human CD261 (DR4, TRAIL-R1)

Antibody type

Monoclonal

Antigen

Extracellular domain of DR4-human IgG1 Fc fusion protein

Description

DR4 is 56 kD member 10A of the TNFR superfamily (TNFRSF10A), also known as TRAIL-R1, Apo-2, and CD261. It is expressed at low levels by activated T cells and some tumors. After TRAIL engagement, DR4 (TRAIL-R1), through activation of NF-κB, induces apoptosis in the TRAIL ligated cell.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Vial size

25 µg

Concentration

0.5 mg/ml

Storage

The antibody solution should be stored undiluted at 4°C.

References

Submitted references

Activation of phosphatidylinositol 3-kinase/Akt signaling pathway mediates acquired resistance to sorafenib in hepatocellular carcinoma cells.

Chen KF, Chen HL, Tai WT, Feng WC, Hsu CH, Chen PJ, Cheng AL
The Journal of pharmacology and experimental therapeutics 2011 Apr;337(1):155-61

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Bortezomib and depsipeptide sensitize tumors to tumor necrosis factor-related apoptosis-inducing ligand: a novel method to potentiate natural killer cell tumor cytotoxicity.

Lundqvist A, Abrams SI, Schrump DS, Alvarez G, Suffredini D, Berg M, Childs R
Cancer research 2006 Jul 15;66(14):7317-25

Flow cytometry

Supportive validation

Submitted by

BioLegend (provider)

Main image

Experimental details

Human DR4 transfected cells stained with purified DJR1, followed by anti-mouse IgG FITC

Conjugate

Unconjugated