Antibody data
- Antibody Data
- Antigen structure
- References [2]
- Comments [0]
- Validations
- Flow cytometry [1]
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- Product number
- 307202 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#307202, RRID:AB_314666
- Product name
- Purified anti-human CD261 (DR4, TRAIL-R1)
- Antibody type
- Monoclonal
- Antigen
- Extracellular domain of DR4-human IgG1 Fc fusion protein
- Description
- DR4 is 56 kD member 10A of the TNFR superfamily (TNFRSF10A), also known as TRAIL-R1, Apo-2, and CD261. It is expressed at low levels by activated T cells and some tumors. After TRAIL engagement, DR4 (TRAIL-R1), through activation of NF-κB, induces apoptosis in the TRAIL ligated cell.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- The antibody solution should be stored undiluted at 4°C.
Submitted references Activation of phosphatidylinositol 3-kinase/Akt signaling pathway mediates acquired resistance to sorafenib in hepatocellular carcinoma cells.
Bortezomib and depsipeptide sensitize tumors to tumor necrosis factor-related apoptosis-inducing ligand: a novel method to potentiate natural killer cell tumor cytotoxicity.
Chen KF, Chen HL, Tai WT, Feng WC, Hsu CH, Chen PJ, Cheng AL
The Journal of pharmacology and experimental therapeutics 2011 Apr;337(1):155-61
The Journal of pharmacology and experimental therapeutics 2011 Apr;337(1):155-61
Bortezomib and depsipeptide sensitize tumors to tumor necrosis factor-related apoptosis-inducing ligand: a novel method to potentiate natural killer cell tumor cytotoxicity.
Lundqvist A, Abrams SI, Schrump DS, Alvarez G, Suffredini D, Berg M, Childs R
Cancer research 2006 Jul 15;66(14):7317-25
Cancer research 2006 Jul 15;66(14):7317-25
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Supportive validation
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- BioLegend (provider)
- Main image
- Experimental details
- Human DR4 transfected cells stained with purified DJR1, followed by anti-mouse IgG FITC
- Conjugate
- Unconjugated