Antibody data
- Antibody Data
- Antigen structure
- References [2]
- Comments [0]
- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- 307207 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#307207, RRID:AB_2256112
- Product name
- APC anti-human CD261 (DR4, TRAIL-R1)
- Antibody type
- Monoclonal
- Antigen
- Extracellular domain of DR4-human IgG1 Fc fusion protein
- Description
- DR4 is 56 kD member 10A of the TNFR superfamily (TNFRSF10A), also known as TRAIL-R1, Apo-2, and CD261. It is expressed at low levels by activated T cells and some tumors. After TRAIL engagement, DR4 (TRAIL-R1), through activation of NF-κB, induces apoptosis in the TRAIL ligated cell.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Red dye
- Isotype
- IgG
- Vial size
- 25 tests
- Storage
- The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Submitted references Enhanced metastasis suppression by targeting TRAIL receptor 2 in a murine model of triple-negative breast cancer.
Bortezomib and depsipeptide sensitize tumors to tumor necrosis factor-related apoptosis-inducing ligand: a novel method to potentiate natural killer cell tumor cytotoxicity.
Malin D, Chen F, Schiller C, Koblinski J, Cryns VL
Clinical cancer research : an official journal of the American Association for Cancer Research 2011 Aug 1;17(15):5005-15
Clinical cancer research : an official journal of the American Association for Cancer Research 2011 Aug 1;17(15):5005-15
Bortezomib and depsipeptide sensitize tumors to tumor necrosis factor-related apoptosis-inducing ligand: a novel method to potentiate natural killer cell tumor cytotoxicity.
Lundqvist A, Abrams SI, Schrump DS, Alvarez G, Suffredini D, Berg M, Childs R
Cancer research 2006 Jul 15;66(14):7317-25
Cancer research 2006 Jul 15;66(14):7317-25
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Supportive validation
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- BioLegend (provider)
- Main image
- Experimental details
- Human DR4 transfected cells stained with DJR1 APC
- Conjugate
- Red dye