12-1550-41
antibody from Invitrogen Antibodies
Targeting: PVR
CD155, HVED, Necl-5, NECL5, PVS, Tage4
Antibody data
- Antibody Data
- Antigen structure
- References [3]
- Comments [0]
- Validations
- Flow cytometry [1]
- Other assay [1]
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Validation data
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- Product number
- 12-1550-41 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- CD155 Monoclonal Antibody (2H7CD155), PE, eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Description: The monoclonal antibody 2H7CD155 recognizes CD155 also known as the poliovirus receptor. The CD155 protein is a member of the Ig superfamily in which 4 isoforms exist; only the alpha and delta forms are expressed on the membrane of monocytes, prostate cancer cells, as well as neurectodermal and monocytic tumor cells lines. In addition, CD155 is found during mid-gastrulation during embryonic development. CD155 is thought to play a role in adhesion by interaction with the ECM component vitronectin as well as a role in NK killing of tumor cells. CD226 and CD96 are ligands for CD155. Blocking of CD155 is under therapeutic investigation for prevention of variants of poliovirus.
- Conjugate
- Yellow dye
- Antibody clone number
- 2H7CD155
- Concentration
- 5 µL/Test
Submitted references TIGIT expressing CD4+T cells represent a tumor-supportive T cell subset in chronic lymphocytic leukemia.
NK cell activation in human hantavirus infection explained by virus-induced IL-15/IL15Rα expression.
Exploration of target molecules for prostate cancer gene therapy.
Catakovic K, Gassner FJ, Ratswohl C, Zaborsky N, Rebhandl S, Schubert M, Steiner M, Gutjahr JC, Pleyer L, Egle A, Hartmann TN, Greil R, Geisberger R
Oncoimmunology 2017;7(1):e1371399
Oncoimmunology 2017;7(1):e1371399
NK cell activation in human hantavirus infection explained by virus-induced IL-15/IL15Rα expression.
Braun M, Björkström NK, Gupta S, Sundström K, Ahlm C, Klingström J, Ljunggren HG
PLoS pathogens 2014 Nov;10(11):e1004521
PLoS pathogens 2014 Nov;10(11):e1004521
Exploration of target molecules for prostate cancer gene therapy.
Suzuki K, Nakamura K, Kato K, Hamada H, Tsukamoto T
The Prostate 2007 Aug 1;67(11):1163-73
The Prostate 2007 Aug 1;67(11):1163-73
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Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Staining of U937 cells with Mouse IgG1 K Isotype Control PE (Product # 12-4714-81) (blue histogram) or Anti-Human CD155 PE (purple histogram). Total viable cells were used for analysis.
- Conjugate
- Yellow dye
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
- Conjugate
- Yellow dye