20276-1-AP

antibody from Proteintech Group

Targeting: LATS2

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunoprecipitation (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Flow cytometry (Supportive data in Antibodypedia)

Antibody Data

Product number

20276-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#20276-1-AP, RRID:AB_10697657

Product name

LATS2-Specific antibody

Antibody type

Polyclonal

Description

KD/KO validated LATS2-Specific antibody (Cat. #20276-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.

Reactivity

Human, Mouse

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

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Pu Y, Wan Y, Shi W, Li B, Zhang H, Wu J, Li L, Guo W, Ding C, Yang W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 May;13(25):e14104

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Small Nucleolar RNA Snord17 Promotes Self-Renewal of Intestinal Stem Cells through Yy2 mRNA Export and Tead4 Activation.

Zhang P, Xu Y, Lan Y, Xiong Z, Yi Z, Wu R, Li C, Du Y, Guo H, Yang Y, Fan Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(13):e12029

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The APC/C subunit APC7 promotes hepatocellular carcinoma progression by mediating ubiquitination and degradation of LATS1 to activate YAP/TAZ.

Sun Y, Zhang R, Guo Y, Wu D, Wei H, Tan Z, Huang M, Wang Y, Fang Z, Zhang C, Li C, Li W, Wei D, Bian H, Liu ZK
Biology direct 2026 Mar 23;21(1)

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ACTL6A accelerates the progression of NSCLC through hippo/YAP signaling axis and TAMs-mediated immune regulation.

Cui L, Zhao S, Lu G, Zhang S, Zhang R, Zhou J, Yao Y
International immunopharmacology 2026 Jan 1;168(Pt 1):115828

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Extracellular vesicles derived from senescent hepatocytes drive pan-cancer metastasis in aging.

Li H, Zhao R, Wan L, Yuan Y, Ma E, Li Y, Chen Z, Liu B, Song Y, Cao Z, Jiao X, Wang Y, Wu P, Jin H, Li J, Yang X, Huang L, Zhang Y, Yang K, Huo J, Jin H, Zhong H, Min M, Zhang S, Cao Y, Li W, Zhang R, Wei C
Nature aging 2026 Apr 6;

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BAP1 Represses Sequential Activation of IRAKs and NF-κB Signaling in Pancreatic Cancer.

Zhao Y, Liang X, Wei R, Guo F, Qin G, Yu H, Liu J, Xia W, Gou S, Wu H, Zhou Y
International journal of biological sciences 2025;21(5):1949-1965

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Diminished nuclear-localized β-adrenoceptor signalling activates YAP to promote kidney fibrosis in diabetic nephropathy.

Xiang W, Li L, Qin M, Li L, Yu H, Wang F, Ni S, Shen A, Lu H, Ni H, Wang Y
British journal of pharmacology 2025 Oct;182(20):4926-4943

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Inhibition of Hippo Signaling Through Ablation of Lats1 and Lats2 Protects Against Cognitive Decline in 5xFAD Mice via Increasing Neuronal Resilience Against Ferroptosis.

Evans RC, Dar NJ, Chen L, Na R, O'Connor JC, Jiang J, Zheng S, Ran Q
Aging cell 2025 Nov;24(11):e70218

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TWF2 Drives Tumor Progression and Sunitinib Resistance in Renal Cell Carcinoma through Hippo Signaling Suppression.

Fu L, Liao W, Tan Y, Lin H, Ye K, Zhou X, Lin M, Huang K, Chen M, Wei J, Feng H, Chen Y, Chen J, Guan B, Li S, Zhang Z, Yu A, Feng Z, Zhang L, Shu G, Lu J, Chen W, Pan Y, Yang J, Luo J, Luo L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(44):e06367

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CuATSM Enhances Wound Repair Without Scarring via Hippo/YAP Signalling Pathway to Reduce Ferroptosis and Macrophage Polarisation.

Tang Y, Ye J, Xu T, Sun Y, Meng W, Zhu L, Jia Z, Wu Q, Chen D, Wu F
Journal of cellular and molecular medicine 2025 Jun;29(12):e70590

---

Gracillin suppresses cancer progression through inducing Merlin/LATS protein-protein interaction and activating Hippo signaling pathway.

Su JX, Zhou HX, Zhang ZJ, Zhou XF, Zou QM, Li SJ, Zhuang XS, Lai JQ, Yang SY, Cui K, Liu YQ, Yuan RJ, Pan HX, Li ZS, Tu HY, Cheng M, Yan Y, Qi Q, Zhang YB
Acta pharmacologica Sinica 2025 Jul;46(7):2016-2028

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PTH counteracts Hippo signaling via Src-dependent YAP stabilization to enhance bone marrow stromal cell differentiation.

Monaci S, Wu M, Okada H, Mesil K, Keum BR, Monseff Rodrigues da Silva M, Rosen CJ, Gori F, Baron R
JCI insight 2025 Aug 22;10(16)

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Overcoming immunotherapy resistance in bladder cancer with a novel antibody-drug conjugate RC48.

Xiao J, Liu J, Zhang C, Liu Z, Nie Z, Yi Z, Gao X, Liang H, Huang J, Cai Z, Yan L, Wu B, Liu Z, Chen J, Zu X, Hu J
Journal for immunotherapy of cancer 2025 Aug 11;13(8)

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Declining activity of serum response factor in aging aorta in relation to aneurysm progression.

Rippe C, Bastrup JA, Holmberg J, Kawka K, Arévalo Martinez M, Albinsson S, Jepps TA, Swärd K
The Journal of biological chemistry 2025 Apr;301(4):108400

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N6-methyladenosine modification of LATS2 promotes hepatoblastoma progression by inhibiting ferroptosis through the YAP1/ATF4/PSAT1 axis.

Zhu G, Xie Y, Bian Z, Ma J, Zhen N, Chen T, Zhu J, Mao S, Tang X, Liu L, Gu S, Ding M, Pan Q
International journal of biological sciences 2024;20(11):4146-4161

---

ACSS2 enables melanoma cell survival and tumor metastasis by negatively regulating the Hippo pathway.

Zhang B, Zhu Q, Qu D, Zhao M, Du J, Zhang H, Wang H, Jiang L, Yi X, Guo S, Wang H, Yang Y, Guo W
Frontiers in molecular biosciences 2024;11:1423795

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YAP1 Suppression by ZDHHC7 Is Associated with Ferroptosis Resistance and Poor Prognosis in Ovarian Clear Cell Carcinoma.

Furutake Y, Yamaguchi K, Yamanoi K, Kitamura S, Takamatsu S, Taki M, Ukita M, Hosoe Y, Murakami R, Abiko K, Horie A, Hamanishi J, Baba T, Matsumura N, Mandai M
Molecular cancer therapeutics 2024 Nov 4;23(11):1652-1665

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The circadian gene ARNTL2 promotes nasopharyngeal carcinoma invasiveness and metastasis through suppressing AMOTL2-LATS-YAP pathway.

Zou W, Lei Y, Ding C, Xiao H, Wang S, Liang S, Luo W, Long Z, He S, Li Q, Qiao H, Liu N, Mao Y
Cell death & disease 2024 Jul 2;15(7):466

---

Extracellular vesicles miR-31-5p promotes pancreatic cancer chemoresistance via regulating LATS2-Hippo pathway and promoting SPARC secretion from pancreatic stellate cells.

Qin C, Zhao B, Wang Y, Li Z, Li T, Zhao Y, Wang W, Zhao Y
Journal of extracellular vesicles 2024 Aug;13(8):e12488

---

Co-transcriptional R-loops-mediated epigenetic regulation drives growth retardation and docetaxel chemosensitivity enhancement in advanced prostate cancer.

Ying Y, Wu Y, Zhang F, Tang Y, Yi J, Ma X, Li J, Chen D, Wang X, Liu X, Liu B, Luo J, Zheng X, Xie L
Molecular cancer 2024 Apr 24;23(1):79

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Proximal Tubular Lats2 Ablation Exacerbates Ischemia/Reperfusion Injury (IRI)-Induced Renal Maladaptive Repair through the Upregulation of P53.

Zhang C, Zheng Z, Xu K, Cheng G, Wu H, Liu J
International journal of molecular sciences 2023 Oct 17;24(20)

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Altering the Cleaving Effector in Chimeric Molecules that Target RNA Enhances Cellular Selectivity.

Suresh BM, Tong Y, Abegg D, Adibekian A, Childs-Disney JL, Disney MD
ACS chemical biology 2023 Nov 17;18(11):2385-2393

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RNF106 aggravates esophageal squamous cell carcinoma progression through LATS2/YAP axis.

Sun Q, Lu H, Zhang W, Du Y, Liang Q, Zhang Y, Wu J, Zhong M
Archives of biochemistry and biophysics 2023 Jul 1;742:109640

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Pharmacological Activation of YAP/TAZ by Targeting LATS1/2 Enhances Periodontal Tissue Regeneration in a Murine Model.

Sato A, Suzuki S, Yuan H, Fahreza RR, Wang X, Nemoto E, Saito M, Yamada S
International journal of molecular sciences 2023 Jan 4;24(2)

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O‑GlcNAcylation mediates endometrial cancer progression by regulating the Hippo‑YAP pathway.

Zhai L, Yang X, Dong J, Qian L, Gao Y, Lv Y, Chen L, Chen B, Zhou F
International journal of oncology 2023 Aug;63(2)

---

Arsenic impairs stem cell differentiation via the Hippo signaling pathway.

Perego MC, McMichael BD, Bain LJ
Toxicology research 2023 Apr;12(2):296-309

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Identifying LATS2 as a prognostic biomarker relevant to immune infiltrates in human esophageal squamous cell carcinoma.

Zhu M, Liao G, Wang Y, Mo J, Yi D, Zhang Y, Xian L
Frontiers in genetics 2022;13:952528

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CircRNA CDR1as promotes cardiomyocyte apoptosis through activating hippo signaling pathway in diabetic cardiomyopathy.

Shao Y, Li M, Yu Q, Gong M, Wang Y, Yang X, Liu L, Liu D, Tan Z, Zhang Y, Qu Y, Li H, Wang Y, Jiao L, Zhang Y
European journal of pharmacology 2022 May 5;922:174915

---

The Hippo signaling component LATS2 enhances innate immunity to inhibit HIV-1 infection through PQBP1-cGAS pathway.

He TS, Dang L, Zhang J, Zhang J, Wang G, Wang E, Xia H, Zhou W, Wu S, Liu X
Cell death and differentiation 2022 Jan;29(1):192-205

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The m(6)A methyltransferase Mettl3 deficiency attenuates hepatic stellate cell activation and liver fibrosis.

Li Y, Kang X, Zhou Z, Pan L, Chen H, Liang X, Chu J, Dong S, Liu C, Yu S, Tu D, Zhang Y, Ge M, Chen W, Xu Y, Zhang Q
Molecular therapy : the journal of the American Society of Gene Therapy 2022 Dec 7;30(12):3714-3728

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SFN Enhanced the Radiosensitivity of Cervical Cancer Cells via Activating LATS2 and Blocking Rad51/MDC1 Recruitment to DNA Damage Site.

Wang S, Wang Y, Liu X, Yang Y, Wu S, Liu Y
Cancers 2022 Apr 8;14(8)

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Tumor-derived exosomal miR-19b-3p facilitates M2 macrophage polarization and exosomal LINC00273 secretion to promote lung adenocarcinoma metastasis via Hippo pathway.

Chen J, Zhang K, Zhi Y, Wu Y, Chen B, Bai J, Wang X
Clinical and translational medicine 2021 Sep;11(9):e478

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CYT387, a potent IKBKE inhibitor, suppresses human glioblastoma progression by activating the Hippo pathway.

Wang X, Lu J, Li J, Liu Y, Guo G, Huang Q
Journal of translational medicine 2021 Sep 20;19(1):396

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Deficiency of large tumor suppressor kinase 1 causes congenital hearing loss associated with cochlear abnormalities in mice.

Nishiyama T, Fujioka M, Saegusa C, Oishi N, Harada T, Hosoya M, Saya H, Ogawa K
Biochemical and biophysical research communications 2021 Jan 1;534:921-926

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Schwannoma development is mediated by Hippo pathway dysregulation and modified by RAS/MAPK signaling.

Chen Z, Li S, Mo J, Hawley E, Wang Y, He Y, Brosseau JP, Shipman T, Clapp DW, Carroll TJ, Le LQ
JCI insight 2020 Oct 15;5(20)

---

Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis.

Wang X, Cai B, Yang X, Sonubi OO, Zheng Z, Ramakrishnan R, Shi H, Valenti L, Pajvani UB, Sandhu J, Infante RE, Radhakrishnan A, Covey DF, Guan KL, Buck J, Levin LR, Tontonoz P, Schwabe RF, Tabas I
Cell metabolism 2020 May 5;31(5):969-986.e7

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The Human Novel Gene LNC-HC Inhibits Hepatocellular Carcinoma Cell Proliferation by Sequestering hsa-miR-183-5p.

Lan X, Wu N, Wu L, Qu K, Osoro EK, Guan D, Du X, Wang B, Chen S, Miao J, Ren J, Liu L, Li H, Ning Q, Li D, Lu S
Molecular therapy. Nucleic acids 2020 Jun 5;20:468-479

---

MicroRNA‑93 promotes angiogenesis and attenuates remodeling via inactivation of the Hippo/Yap pathway by targeting Lats2 after myocardial infarctionω.

Ma C, Peng P, Zhou Y, Liu T, Wang L, Lu C
Molecular medicine reports 2020 Jul;22(1):483-493

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Hippo pathway and tumoral FOXP3 expression correlate with tumor growth in squamous cell carcinoma of the lung.

Won KY, Kim HK, Kim GY, Song MJ, Lim SJ
Pathology, research and practice 2020 Jul;216(7):153003

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TRIB3 confers radiotherapy resistance in esophageal squamous cell carcinoma by stabilizing TAZ.

Zhou S, Liu S, Lin C, Li Y, Ye L, Wu X, Jian Y, Dai Y, Ouyang Y, Zhao L, Liu M, Song L, Xi M
Oncogene 2020 Apr;39(18):3710-3725

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miR-25 Promotes Cell Proliferation, Migration, and Invasion of Non-Small-Cell Lung Cancer by Targeting the LATS2/YAP Signaling Pathway.

Wu T, Hu H, Zhang T, Jiang L, Li X, Liu S, Zheng C, Yan G, Chen W, Ning Y, Li Y, Lu Z
Oxidative medicine and cellular longevity 2019;2019:9719723

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Essential Oil from Pinus Koraiensis Pinecones Inhibits Gastric Cancer Cells via the HIPPO/YAP Signaling Pathway.

Zhang Y, Xin C, Qiu J, Wang Z
Molecules (Basel, Switzerland) 2019 Oct 25;24(21)

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The CalcR-PKA-Yap1 Axis Is Critical for Maintaining Quiescence in Muscle Stem Cells.

Zhang L, Noguchi YT, Nakayama H, Kaji T, Tsujikawa K, Ikemoto-Uezumi M, Uezumi A, Okada Y, Doi T, Watanabe S, Braun T, Fujio Y, Fukada SI
Cell reports 2019 Nov 19;29(8):2154-2163.e5

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CLDN6 promotes tumor progression through the YAP1-snail1 axis in gastric cancer.

Yu S, Zhang Y, Li Q, Zhang Z, Zhao G, Xu J
Cell death & disease 2019 Dec 11;10(12):949

---

Myricetin Suppresses the Propagation of Hepatocellular Carcinoma via Down-Regulating Expression of YAP.

Li M, Chen J, Yu X, Xu S, Li D, Zheng Q, Yin Y
Cells 2019 Apr 17;8(4)

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YAP triggers the Wnt/β-catenin signalling pathway and promotes enterocyte self-renewal, regeneration and tumorigenesis after DSS-induced injury.

Deng F, Peng L, Li Z, Tan G, Liang E, Chen S, Zhao X, Zhi F
Cell death & disease 2018 Feb 2;9(2):153

---

Large tumor suppressor 2, LATS2, activates JNK in a kinase-independent mechanism through ASK1.

Rusnak L, Tang C, Qi Q, Mo X, Fu H
Journal of molecular cell biology 2018 Dec 1;10(6):549-558

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A comprehensive evaluation of Hippo pathway silencing in sarcomas.

Merritt NM, Fullenkamp CA, Hall SL, Qian Q, Desai C, Thomason J, Lambertz AM, Dupuy AJ, Darbro B, Tanas MR
Oncotarget 2018 Aug 3;9(60):31620-31636

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Expression of tumoral FOXP3 in gastric adenocarcinoma is associated with favorable clinicopathological variables and related with Hippo pathway.

Suh JH, Won KY, Kim GY, Bae GE, Lim SJ, Sung JY, Park YK, Kim YW, Lee J
International journal of clinical and experimental pathology 2015;8(11):14608-18

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MicroRNA-31 activates the RAS pathway and functions as an oncogenic MicroRNA in human colorectal cancer by repressing RAS p21 GTPase activating protein 1 (RASA1).

Sun D, Yu F, Ma Y, Zhao R, Chen X, Zhu J, Zhang CY, Chen J, Zhang J
The Journal of biological chemistry 2013 Mar 29;288(13):9508-18

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

SGC-7901 cells were subjected to SDS PAGE followed by western blot with 20276-1-AP(LATS2-Specific antibody) at dilution of 1:500

Sample type

cell line

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human heart using 20276-1-AP(LATS2-Specific antibody) at dilution of 1:100 (under 10x lens)

Sample type

tissue

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human heart using 20276-1-AP(LATS2-Specific antibody) at dilution of 1:100 (under 40x lens)

Sample type

tissue

Flow cytometry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The LATS2-Specific antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human LATS2-Specific. This antibody recognizes human antigen. The LATS2-Specific antibody has been validated for the following applications: ELISA, WB, IHC, FC analysis.

Appendix

20276-1-AP.pdf

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