APR03970G

antibody from Leading Biology

Targeting: PSMB5 MB1

Western blot (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

APR03970G

Provider

Leading Biology

Product name

PSMB5 Antibody (C-term)

Antibody type

Polyclonal

Description

The proteasome is a multicatalytic proteinase complex witha highly ordered ring-shaped 20S core structure. The core structureis composed of 4 rings of 28 non-identical subunits; 2 rings arecomposed of 7 alpha subunits and 2 rings are composed of 7 betasubunits. Proteasomes are distributed throughout eukaryotic cellsat a high concentration and cleave peptides in anATP/ubiquitin-dependent process in a non-lysosomal pathway. Anessential function of a modified proteasome, the immunoproteasome,is the processing of class I MHC peptides. This gene encodes amember of the proteasome B-type family, also known as the T1Bfamily, that is a 20S core beta subunit in the proteasome. Thiscatalytic subunit is not present in the immunoproteasome and isreplaced by catalytic subunit 3i (proteasome beta 8 subunit).Multiple transcript variants encoding different isoforms have beenfound for this gene.

Reactivity

Human

Host

Rabbit

Storage

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.