17810-1-AP

antibody from Proteintech Group

Targeting: RNF4 RES4-26, SLX5, SNURF

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunoprecipitation (Data presented on provider website)

Antibody Data

Product number

17810-1-AP

Provider

Proteintech Group

Product name

RNF4 antibody

Antibody type

Polyclonal

Description

RNF4 antibody (Cat. #17810-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IP, WB,ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Development of the first-in-class RNF4 PROTAC degrader as potential therapeutics for hepatocellular carcinoma.

Wan H, Liu Y, Chang H, Zhang K, Li Z, Ni H, Xu J, Pan B, Zhu K, Hu J, Wang S, Yang D, Wang X, Dang Y, Zhu S
European journal of medicinal chemistry 2026 Apr 5;307:118668

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Phase separation of ERCC6L2-CtIP regulates the extent of DNA end resection.

Yin Y, Lin J, Cai X, Nie R, Lin J, Li S, Xiang Z, Ling Y, Zhang Y, Zhou J, Chen J, Lin W, Duan J, Zheng X, Xie D, Cai M
Nature cell biology 2025 Oct;27(10):1771-1784

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Meisoindigo Acts as a Molecular Glue to Target PKMYT1 for Degradation in Chronic Myeloid Leukemia Therapy.

Zhang ZX, Li SY, Li FF, Shi QY, Tan CY, Wang XJ, Li M, Liu YB, Jin J, Li Y, Yu SS
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jun;12(21):e2413676

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TEX264 drives selective autophagy of DNA lesions to promote DNA repair and cell survival.

Lascaux P, Hoslett G, Tribble S, Trugenberger C, Antičević I, Otten C, Torrecilla I, Koukouravas S, Zhao Y, Yang H, Aljarbou F, Ruggiano A, Song W, Peron C, Deangeli G, Domingo E, Bancroft J, Carrique L, Johnson E, Vendrell I, Fischer R, Ng AWT, Ngeow J, D'Angiolella V, Raimundo N, Maughan T, Popović M, Milošević I, Ramadan K
Cell 2024 Oct 3;187(20):5698-5718.e26

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RNF4 mediated degradation of PDHA1 promotes colorectal cancer metabolism and metastasis.

Chen J, Li ZY, Zheng G, Cao L, Guo YM, Lian Q, Gu B, Yue CF
NPJ precision oncology 2024 Nov 9;8(1):258

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CSF2RB overexpression promotes the protective effects of mesenchymal stromal cells against ischemic heart injury.

Qi T, Xu X, Guo Y, Xia Y, Peng L, Li C, Ding F, Gao C, Fan M, Yu M, Zhao H, He Y, Li W, Hai C, Gao E, Zhang X, Gao F, Fan Y, Yan W, Tao L
Theranostics 2023;13(6):1759-1773

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Analysis of a degron-containing reporter protein GFP-CL1 reveals a role for SUMO1 in cytosolic protein quality control.

Wang W, Lu J, Yang WC, Spear ED, Michaelis S, Matunis MJ
The Journal of biological chemistry 2023 Feb;299(2):102851

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Crosstalk between SUMOylation and ubiquitylation controls DNA end resection by maintaining MRE11 homeostasis on chromatin.

Zhang T, Yang H, Zhou Z, Bai Y, Wang J, Wang W
Nature communications 2022 Sep 1;13(1):5133

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RNF4 promotes tumorigenesis, therapy resistance of cholangiocarcinoma and affects cell cycle by regulating the ubiquitination degradation of p27kip1 in the nucleus.

Huang J, Yang W, Jiang K, Liu Y, Tan X, Luo J
Experimental cell research 2022 Oct 1;419(1):113295

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The E3 Ubiquitin-Protein Ligase RNF4 Promotes TNF-α-Induced Cell Death Triggered by RIPK1.

Shimada T, Kudoh Y, Noguchi T, Kagi T, Suzuki M, Tsuchida M, Komatsu H, Takahashi M, Hirata Y, Matsuzawa A
International journal of molecular sciences 2021 May 28;22(11)

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Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications.

Ward CC, Kleinman JI, Brittain SM, Lee PS, Chung CYS, Kim K, Petri Y, Thomas JR, Tallarico JA, McKenna JM, Schirle M, Nomura DK
ACS chemical biology 2019 Nov 15;14(11):2430-2440