Antibody data
- Antibody Data
- Antigen structure
- References [33]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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Validation data
Reference
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- Product number
- 12452-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12452-1-AP, RRID:AB_2299709
- Product name
- VPS34 (C terminal) antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated VPS34 (C terminal) antibody (Cat. #12452-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Cyclic helix B peptide promotes random-pattern skin flap survival via TFE3-mediated enhancement of autophagy and reduction of ROS levels.
GDF-11 Protects the Traumatically Injured Spinal Cord by Suppressing Pyroptosis and Necroptosis via TFE3-Mediated Autophagy Augmentation.
Liraglutide, a TFEB-Mediated Autophagy Agonist, Promotes the Viability of Random-Pattern Skin Flaps.
Betulinic acid inhibits pyroptosis in spinal cord injury by augmenting autophagy via the AMPK-mTOR-TFEB signaling pathway.
Curcumin promotes the survival of ischemic random skin flaps via autophagy.
Pseudoginsenoside F11 Enhances the Viability of Random-Pattern Skin Flaps by Promoting TFEB Nuclear Translocation Through AMPK-mTOR Signal Pathway.
The effects of mTOR or Vps34-mediated autophagy on methylmercury-induced neuronal apoptosis in rat cerebral cortex.
Targeting PP2A with lomitapide suppresses colorectal tumorigenesis through the activation of AMPK/Beclin1-mediated autophagy.
SHISA5/SCOTIN restrains spontaneous autophagy induction by blocking contact between the ERES and phagophores.
Bunyavirus SFTSV exploits autophagic flux for viral assembly and egress.
OAB-14 Effectively Ameliorates the Dysfunction of the Endosomal-Autophagic-Lysosomal Pathway in APP/PS1 Transgenic Mice.
Exenatide improves random-pattern skin flap survival via TFE3 mediated autophagy augment.
Autophagy Alters Bladder Angiogenesis and Improves Bladder Hyperactivity in the Pathogenesis of Ketamine-Induced Cystitis in a Rat Model.
VPS34 regulates dynamin to determine the endocytosis of mitochondria-targeted zinc oxide nanoparticles in human osteosarcoma cells.
Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes.
IL-6 regulates autophagy and chemotherapy resistance by promoting BECN1 phosphorylation.
Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response.
Autophagic elimination of ribosomes during spermiogenesis provides energy for flagellar motility.
Protective autophagy attenuates soft substrate-induced apoptosis through ROS/JNK signaling pathway in breast cancer cells.
Hydroxysafflor yellow A promotes multiterritory perforating flap survival: an experimental study.
Butylphthalide Inhibits Autophagy and Promotes Multiterritory Perforator Flap Survival.
Baicalein Attenuates Pyroptosis and Endoplasmic Reticulum Stress Following Spinal Cord Ischemia-Reperfusion Injury via Autophagy Enhancement.
TFE3, a potential therapeutic target for Spinal Cord Injury via augmenting autophagy flux and alleviating ER stress.
Vps34 derived phosphatidylinositol 3-monophosphate modulates megakaryocyte maturation and proplatelet production through late endosomes/lysosomes.
LncRNA PVT1 promotes gemcitabine resistance of pancreatic cancer via activating Wnt/β-catenin and autophagy pathway through modulating the miR-619-5p/Pygo2 and miR-619-5p/ATG14 axes.
Protective effects of resveratrol on random-pattern skin flap survival: an experimental study.
Betulinic Acid Enhances the Viability of Random-Pattern Skin Flaps by Activating Autophagy.
FGF21 augments autophagy in random-pattern skin flaps via AMPK signaling pathways and improves tissue survival.
TGF-β1 inhibits the autophagy of podocytes by activating mTORC1 in IgA nephropathy.
Salvianolic Acid B Promotes the Survival of Random-Pattern Skin Flaps in Rats by Inducing Autophagy.
MAP1B-LC1 prevents autophagosome formation by linking syntaxin 17 to microtubules.
β-Arrestins promote podocyte injury by inhibition of autophagy in diabetic nephropathy.
Modification of BECN1 by ISG15 plays a crucial role in autophagy regulation by type I IFN/interferon.
Lou J, Zhang H, Qi J, Xu Y, Wang X, Jiang J, Hu X, Ni L, Cai Y, Wang X, Gao W, Xiao J, Zhou K
British journal of pharmacology 2022 Jan;179(2):301-321
British journal of pharmacology 2022 Jan;179(2):301-321
GDF-11 Protects the Traumatically Injured Spinal Cord by Suppressing Pyroptosis and Necroptosis via TFE3-Mediated Autophagy Augmentation.
Xu Y, Hu X, Li F, Zhang H, Lou J, Wang X, Wang H, Yin L, Ni W, Kong J, Wang X, Li Y, Zhou K, Xu H
Oxidative medicine and cellular longevity 2021;2021:8186877
Oxidative medicine and cellular longevity 2021;2021:8186877
Liraglutide, a TFEB-Mediated Autophagy Agonist, Promotes the Viability of Random-Pattern Skin Flaps.
Zhu X, Hu X, Lou J, Li J, Xu Y, Yu G, Wu C, Ding J, Gao W, Xiao J, Zhou K, Jia C
Oxidative medicine and cellular longevity 2021;2021:6610603
Oxidative medicine and cellular longevity 2021;2021:6610603
Betulinic acid inhibits pyroptosis in spinal cord injury by augmenting autophagy via the AMPK-mTOR-TFEB signaling pathway.
Wu C, Chen H, Zhuang R, Zhang H, Wang Y, Hu X, Xu Y, Li J, Li Y, Wang X, Xu H, Ni W, Zhou K
International journal of biological sciences 2021;17(4):1138-1152
International journal of biological sciences 2021;17(4):1138-1152
Curcumin promotes the survival of ischemic random skin flaps via autophagy.
Tu Z, Jiang X, Li Y, Yang S, Lin D, Shi Y, Mao C, Zhang X, Lin C
American journal of translational research 2021;13(3):1337-1351
American journal of translational research 2021;13(3):1337-1351
Pseudoginsenoside F11 Enhances the Viability of Random-Pattern Skin Flaps by Promoting TFEB Nuclear Translocation Through AMPK-mTOR Signal Pathway.
Zhou F, Zhang X, Jiang L, Li S, Chen Y, Wu J
Frontiers in pharmacology 2021;12:667524
Frontiers in pharmacology 2021;12:667524
The effects of mTOR or Vps34-mediated autophagy on methylmercury-induced neuronal apoptosis in rat cerebral cortex.
Ni L, Wei Y, Pan J, Li X, Xu B, Deng Y, Yang T, Liu W
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Sep;155:112386
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Sep;155:112386
Targeting PP2A with lomitapide suppresses colorectal tumorigenesis through the activation of AMPK/Beclin1-mediated autophagy.
Zuo Q, Liao L, Yao ZT, Liu YP, Wang DK, Li SJ, Yin XF, He QY, Xu WW
Cancer letters 2021 Sep 9;521:281-293
Cancer letters 2021 Sep 9;521:281-293
SHISA5/SCOTIN restrains spontaneous autophagy induction by blocking contact between the ERES and phagophores.
Lee JE, Kim N, Jung M, Mun JY, Yoo JY
Autophagy 2021 Oct 31;:1-16
Autophagy 2021 Oct 31;:1-16
Bunyavirus SFTSV exploits autophagic flux for viral assembly and egress.
Yan JM, Zhang WK, Yan LN, Jiao YJ, Zhou CM, Yu XJ
Autophagy 2021 Nov 6;:1-14
Autophagy 2021 Nov 6;:1-14
OAB-14 Effectively Ameliorates the Dysfunction of the Endosomal-Autophagic-Lysosomal Pathway in APP/PS1 Transgenic Mice.
Guo X, Bao X, Wang X, Liu D, Liu P, Chi T, Ji X, Zheng Z, Chen G, Zou L
ACS chemical neuroscience 2021 Nov 3;12(21):3985-3993
ACS chemical neuroscience 2021 Nov 3;12(21):3985-3993
Exenatide improves random-pattern skin flap survival via TFE3 mediated autophagy augment.
Li J, Chen H, Lou J, Bao G, Wu C, Lou Z, Wang X, Ding J, Li Z, Xiao J, Xu H, Gao W, Zhou K
Journal of cellular physiology 2021 May;236(5):3641-3659
Journal of cellular physiology 2021 May;236(5):3641-3659
Autophagy Alters Bladder Angiogenesis and Improves Bladder Hyperactivity in the Pathogenesis of Ketamine-Induced Cystitis in a Rat Model.
Lu JH, Wu YH, Juan TJ, Lin HY, Lin RJ, Chueh KS, Lee YC, Chang CY, Juan YS
Biology 2021 May 30;10(6)
Biology 2021 May 30;10(6)
VPS34 regulates dynamin to determine the endocytosis of mitochondria-targeted zinc oxide nanoparticles in human osteosarcoma cells.
Pan X, He G, Hai B, Liu Y, Bian L, Yong L, Zhang H, Yang C, Du C, Mao T, Ma Y, Jia F, Dou X, Zhai S, Liu X
Journal of materials chemistry. B 2021 Mar 21;9(11):2641-2655
Journal of materials chemistry. B 2021 Mar 21;9(11):2641-2655
Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes.
Tremel S, Ohashi Y, Morado DR, Bertram J, Perisic O, Brandt LTL, von Wrisberg MK, Chen ZA, Maslen SL, Kovtun O, Skehel M, Rappsilber J, Lang K, Munro S, Briggs JAG, Williams RL
Nature communications 2021 Mar 10;12(1):1564
Nature communications 2021 Mar 10;12(1):1564
IL-6 regulates autophagy and chemotherapy resistance by promoting BECN1 phosphorylation.
Hu F, Song D, Yan Y, Huang C, Shen C, Lan J, Chen Y, Liu A, Wu Q, Sun L, Xu F, Hu F, Chen L, Luo X, Feng Y, Huang S, Hu J, Wang G
Nature communications 2021 Jun 15;12(1):3651
Nature communications 2021 Jun 15;12(1):3651
Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response.
Wang W, Li J, Tan J, Wang M, Yang J, Zhang ZM, Li C, Basnakian AG, Tang HW, Perrimon N, Zhou Q
Nature communications 2021 Jan 20;12(1):476
Nature communications 2021 Jan 20;12(1):476
Autophagic elimination of ribosomes during spermiogenesis provides energy for flagellar motility.
Lei Y, Zhang X, Xu Q, Liu S, Li C, Jiang H, Lin H, Kong E, Liu J, Qi S, Li H, Xu W, Lu K
Developmental cell 2021 Aug 23;56(16):2313-2328.e7
Developmental cell 2021 Aug 23;56(16):2313-2328.e7
Protective autophagy attenuates soft substrate-induced apoptosis through ROS/JNK signaling pathway in breast cancer cells.
Chen Y, Li P, Peng Y, Xie X, Zhang Y, Jiang Y, Li T, Qin X, Li S, Yang H, Wu C, Zheng C, Zhu J, You F, Liu Y
Free radical biology & medicine 2021 Aug 20;172:590-603
Free radical biology & medicine 2021 Aug 20;172:590-603
Hydroxysafflor yellow A promotes multiterritory perforating flap survival: an experimental study.
Zhang C, Shao Z, Chen Z, Lin C, Hu S, Lou Z, Li J, Zheng X, Lin N, Gao W
American journal of translational research 2020;12(8):4781-4794
American journal of translational research 2020;12(8):4781-4794
Butylphthalide Inhibits Autophagy and Promotes Multiterritory Perforator Flap Survival.
Li B, Chen Z, Luo X, Zhang C, Chen H, Wang S, Zhao M, Ma H, Liu J, Cheng M, Yang Y, Yan H
Frontiers in pharmacology 2020;11:612932
Frontiers in pharmacology 2020;11:612932
Baicalein Attenuates Pyroptosis and Endoplasmic Reticulum Stress Following Spinal Cord Ischemia-Reperfusion Injury via Autophagy Enhancement.
Wu C, Xu H, Li J, Hu X, Wang X, Huang Y, Li Y, Sheng S, Wang Y, Xu H, Ni W, Zhou K
Frontiers in pharmacology 2020;11:1076
Frontiers in pharmacology 2020;11:1076
TFE3, a potential therapeutic target for Spinal Cord Injury via augmenting autophagy flux and alleviating ER stress.
Zhou K, Zheng Z, Li Y, Han W, Zhang J, Mao Y, Chen H, Zhang W, Liu M, Xie L, Zhang H, Xu H, Xiao J
Theranostics 2020;10(20):9280-9302
Theranostics 2020;10(20):9280-9302
Vps34 derived phosphatidylinositol 3-monophosphate modulates megakaryocyte maturation and proplatelet production through late endosomes/lysosomes.
Bertović I, Kurelić R, Milošević I, Bender M, Krauss M, Haucke V, Jurak Begonja A
Journal of thrombosis and haemostasis : JTH 2020 Jul;18(7):1756-1772
Journal of thrombosis and haemostasis : JTH 2020 Jul;18(7):1756-1772
LncRNA PVT1 promotes gemcitabine resistance of pancreatic cancer via activating Wnt/β-catenin and autophagy pathway through modulating the miR-619-5p/Pygo2 and miR-619-5p/ATG14 axes.
Zhou C, Yi C, Yi Y, Qin W, Yan Y, Dong X, Zhang X, Huang Y, Zhang R, Wei J, Ali DW, Michalak M, Chen XZ, Tang J
Molecular cancer 2020 Jul 29;19(1):118
Molecular cancer 2020 Jul 29;19(1):118
Protective effects of resveratrol on random-pattern skin flap survival: an experimental study.
Lin J, Lin R, Li S, Wu H, Ding J, Xiang G, Li S, Wang Y, Lin D, Gao W, Kong J, Xu H, Zhou K
American journal of translational research 2019;11(1):379-392
American journal of translational research 2019;11(1):379-392
Betulinic Acid Enhances the Viability of Random-Pattern Skin Flaps by Activating Autophagy.
Li J, Bao G, ALyafeai E, Ding J, Li S, Sheng S, Shen Z, Jia Z, Lin C, Zhang C, Lou Z, Xu H, Gao W, Zhou K
Frontiers in pharmacology 2019;10:1017
Frontiers in pharmacology 2019;10:1017
FGF21 augments autophagy in random-pattern skin flaps via AMPK signaling pathways and improves tissue survival.
Zhou K, Chen H, Lin J, Xu H, Wu H, Bao G, Li J, Deng X, Shui X, Gao W, Ding J, Xiao J, Xu H
Cell death & disease 2019 Nov 18;10(12):872
Cell death & disease 2019 Nov 18;10(12):872
TGF-β1 inhibits the autophagy of podocytes by activating mTORC1 in IgA nephropathy.
Mao X, Xu Z, Xu X, Zeng M, Zhao Z, Zhang Z, Ding X, Wu H
Experimental cell research 2019 Dec 1;385(1):111670
Experimental cell research 2019 Dec 1;385(1):111670
Salvianolic Acid B Promotes the Survival of Random-Pattern Skin Flaps in Rats by Inducing Autophagy.
Lin J, Lin R, Li S, Wu H, Ding J, Xiang G, Li S, Wang Y, Lin D, Gao W, Kong J, Xu H, Zhou K
Frontiers in pharmacology 2018;9:1178
Frontiers in pharmacology 2018;9:1178
MAP1B-LC1 prevents autophagosome formation by linking syntaxin 17 to microtubules.
Arasaki K, Nagashima H, Kurosawa Y, Kimura H, Nishida N, Dohmae N, Yamamoto A, Yanagi S, Wakana Y, Inoue H, Tagaya M
EMBO reports 2018 Aug;19(8)
EMBO reports 2018 Aug;19(8)
β-Arrestins promote podocyte injury by inhibition of autophagy in diabetic nephropathy.
Liu J, Li QX, Wang XJ, Zhang C, Duan YQ, Wang ZY, Zhang Y, Yu X, Li NJ, Sun JP, Yi F
Cell death & disease 2016 Apr 7;7:e2183
Cell death & disease 2016 Apr 7;7:e2183
Modification of BECN1 by ISG15 plays a crucial role in autophagy regulation by type I IFN/interferon.
Xu D, Zhang T, Xiao J, Zhu K, Wei R, Wu Z, Meng H, Li Y, Yuan J
Autophagy 2015 Apr 3;11(4):617-28
Autophagy 2015 Apr 3;11(4):617-28
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- PC-3 cells were subjected to SDS PAGE followed by western blot with 12452-1-AP(PIK3C3 antibody) at dilution of 1:400
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human heart using 12452-1-AP(PIK3C3 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The VPS34 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human VPS34. This antibody recognizes human,mouse,rat antigen. The VPS34 antibody has been validated for the following applications: ELISA, WB, IHC analysis.