Antibody data
- Antibody Data
- Antigen structure
- References [73]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 12452-1-AP - Provider product page

- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12452-1-AP, RRID:AB_2299709
- Product name
- VPS34 (C terminal) antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated VPS34 (C terminal) antibody (Cat. #12452-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Aspergillus fumigatus Gliotoxin Inhibits LC3-Associated Phagocytosis in Macrophages in a Calcium-Dependent Manner.
Ginsenoside Rg3 Mitigates LPS-Induced Injury in Human Bronchial Epithelial Cells by Restoring Autophagic Flux and Inhibiting the TLR4/NF-κB-Mediated Inflammatory Response.
Schisandrin B enhances autophagy and random flaps survival through the PPARG-mediated PI3K/AKT/mTOR signaling pathway.
PSAT1 inhibits mTORC1 activation by preventing Rag heterodimer formation in lung adenocarcinoma.
Inhibition of ESCRT-III activates alternative pathways for protein degradation and secretion.
Licochalcone A promotes autophagy to ameliorate NAFLD by inhibiting the mTOR and regulating ULK1/Beclin1/VPS34 pathway.
Bletilla striata polysaccharide induces autophagy through PI3K/AKT signaling pathway to promote the survival of cross-boundary flap in rats.
LZTR1 is a melanoma oncogene that promotes invasion and suppresses apoptosis.
Transferrin receptor controls both autophagosome formation and closure via phosphatidylinositol 3-phosphate synthesis.
Macelignan Improves Functional Recovery After Spinal Cord Injury by Augmenting Autophagy via the AKT-mTOR-TFEB Signaling Pathway.
Regulation of N-degron recognin-mediated autophagy by the SARS-CoV-2 PLpro ubiquitin deconjugase.
Kit-mediated autophagy suppression driven by a viral oncoprotein emerges as a crucial survival mechanism in Merkel cell carcinoma.
MLKL-USP7-UBA52 signaling is indispensable for autophagy in brain through maintaining ubiquitin homeostasis.
Astragalin inhibits neuronal excitability and activates neuronal autophagy in the ACC and LH of CFA mice to alleviate inflammatory pain and pain-related emotions.
Trehalose Rescues Postmenopausal Osteoporosis Induced by Ovariectomy through Alleviating Osteoblast Pyroptosis via Promoting Autophagy.
Bunyavirus SFTSV NSs utilizes autophagy to escape the antiviral innate immune response.
NEMO-Binding Domain/IKKγ Inhibitory Peptide Alleviates Neuronal Pyroptosis in Spinal Cord Injury by Inhibiting ASMase-Induced Lysosome Membrane Permeabilization.
Overcoming multi-drug resistance in SCLC: a synergistic approach with venetoclax and hydroxychloroquine targeting the lncRNA LYPLAL1-DT/BCL2/BECN1 pathway.
VD(3)/VDR attenuates bisphenol A-induced impairment in mouse Leydig cells via regulation of autophagy.
Celastrol enhances the viability of random-pattern skin flaps by regulating autophagy through the AMPK-mTOR-TFEB axis.
FGF-18 Protects the Injured Spinal cord in mice by Suppressing Pyroptosis and Promoting Autophagy via the AKT-mTOR-TRPML1 axis.
Sesamin-mediated high expression of BECN2 ameliorates cartilage endplate degeneration by reducing autophagy and inflammation.
Ezrin inhibition alleviates oxidative stress and pyroptosis via regulating TRPML1-calcineurin axis mediated enhancement of autophagy in spinal cord injury.
Corynoxine triggers cell death via activating PP2A and regulating AKT-mTOR/GSK3β axes in NSCLC.
Echovirus induces autophagy to promote viral replication via regulating mTOR/ULK1 signaling pathway.
Assessment of Autophagy Markers Suggests Increased Activity Following LVAD Therapy.
MARCH7-mediated ubiquitination decreases the solubility of ATG14 to inhibit autophagy.
Realgar-Induced Neurotoxicity: Crosstalk Between the Autophagic Flux and the p62-NRF2 Feedback Loop Mediates p62 Accumulation to Promote Apoptosis.
Rosuvastatin promotes survival of random skin flaps through AMPK-mTOR pathway-induced autophagy.
Sinomenine promotes flap survival by upregulating eNOS and eNOS-mediated autophagy via PI3K/AKT pathway.
Partial inhibition of class III PI3K VPS-34 ameliorates motor aging and prolongs health span.
Elamipretide alleviates pyroptosis in traumatically injured spinal cord by inhibiting cPLA2-induced lysosomal membrane permeabilization.
Piperine attenuates the inflammation, oxidative stress, and pyroptosis to facilitate recovery from spinal cord injury via autophagy enhancement.
Cyclic helix B peptide alleviates proinflammatory cell death and improves functional recovery after traumatic spinal cord injury.
Diallyl Trisulfide Enhances the Survival of Multiterritory Perforator Skin Flaps.
An Experimental Study Reveals the Protective Effect of Autophagy against Realgar-Induced Liver Injury via Suppressing ROS-Mediated NLRP3 Inflammasome Pathway.
SHISA5/SCOTIN restrains spontaneous autophagy induction by blocking contact between the ERES and phagophores.
Bunyavirus SFTSV exploits autophagic flux for viral assembly and egress.
Cyclic helix B peptide promotes random-pattern skin flap survival via TFE3-mediated enhancement of autophagy and reduction of ROS levels.
Phosphorylated STYK1 restrains the inhibitory role of EGFR in autophagy initiation and EGFR-TKIs sensitivity.
Inhibition of autophagy potentiates the cytotoxicity of the irreversible FGFR1-4 inhibitor FIIN-2 on lung adenocarcinoma.
Paraquat Inhibits Autophagy Via Intensifying the Interaction Between HMGB1 and α-Synuclein.
GDF-11 Protects the Traumatically Injured Spinal Cord by Suppressing Pyroptosis and Necroptosis via TFE3-Mediated Autophagy Augmentation.
Liraglutide, a TFEB-Mediated Autophagy Agonist, Promotes the Viability of Random-Pattern Skin Flaps.
Betulinic acid inhibits pyroptosis in spinal cord injury by augmenting autophagy via the AMPK-mTOR-TFEB signaling pathway.
Curcumin promotes the survival of ischemic random skin flaps via autophagy.
Pseudoginsenoside F11 Enhances the Viability of Random-Pattern Skin Flaps by Promoting TFEB Nuclear Translocation Through AMPK-mTOR Signal Pathway.
The effects of mTOR or Vps34-mediated autophagy on methylmercury-induced neuronal apoptosis in rat cerebral cortex.
OAB-14 Effectively Ameliorates the Dysfunction of the Endosomal-Autophagic-Lysosomal Pathway in APP/PS1 Transgenic Mice.
Targeting PP2A with lomitapide suppresses colorectal tumorigenesis through the activation of AMPK/Beclin1-mediated autophagy.
Exenatide improves random-pattern skin flap survival via TFE3 mediated autophagy augment.
Autophagy Alters Bladder Angiogenesis and Improves Bladder Hyperactivity in the Pathogenesis of Ketamine-Induced Cystitis in a Rat Model.
VPS34 regulates dynamin to determine the endocytosis of mitochondria-targeted zinc oxide nanoparticles in human osteosarcoma cells.
Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes.
IL-6 regulates autophagy and chemotherapy resistance by promoting BECN1 phosphorylation.
Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response.
Autophagic elimination of ribosomes during spermiogenesis provides energy for flagellar motility.
Protective autophagy attenuates soft substrate-induced apoptosis through ROS/JNK signaling pathway in breast cancer cells.
Hydroxysafflor yellow A promotes multiterritory perforating flap survival: an experimental study.
Butylphthalide Inhibits Autophagy and Promotes Multiterritory Perforator Flap Survival.
Baicalein Attenuates Pyroptosis and Endoplasmic Reticulum Stress Following Spinal Cord Ischemia-Reperfusion Injury via Autophagy Enhancement.
TFE3, a potential therapeutic target for Spinal Cord Injury via augmenting autophagy flux and alleviating ER stress.
Vps34 derived phosphatidylinositol 3-monophosphate modulates megakaryocyte maturation and proplatelet production through late endosomes/lysosomes.
LncRNA PVT1 promotes gemcitabine resistance of pancreatic cancer via activating Wnt/β-catenin and autophagy pathway through modulating the miR-619-5p/Pygo2 and miR-619-5p/ATG14 axes.
Metformin Promotes the Survival of Random-Pattern Skin Flaps by Inducing Autophagy via the AMPK-mTOR-TFEB signaling pathway.
Protective effects of resveratrol on random-pattern skin flap survival: an experimental study.
Betulinic Acid Enhances the Viability of Random-Pattern Skin Flaps by Activating Autophagy.
FGF21 augments autophagy in random-pattern skin flaps via AMPK signaling pathways and improves tissue survival.
TGF-β1 inhibits the autophagy of podocytes by activating mTORC1 in IgA nephropathy.
Salvianolic Acid B Promotes the Survival of Random-Pattern Skin Flaps in Rats by Inducing Autophagy.
MAP1B-LC1 prevents autophagosome formation by linking syntaxin 17 to microtubules.
β-Arrestins promote podocyte injury by inhibition of autophagy in diabetic nephropathy.
Modification of BECN1 by ISG15 plays a crucial role in autophagy regulation by type I IFN/interferon.
Sun Y, Chen F, Zhang L, Zheng C, Wang Y, Zhang Y, Han L
Journal of immunology research 2026;2026(1):e5542735
Journal of immunology research 2026;2026(1):e5542735
Ginsenoside Rg3 Mitigates LPS-Induced Injury in Human Bronchial Epithelial Cells by Restoring Autophagic Flux and Inhibiting the TLR4/NF-κB-Mediated Inflammatory Response.
Tao X, Liu L, Gu X, Jia B, Yu Q, Wei Y, Zhang W, Zhou J
Journal of inflammation research 2026;19:555053
Journal of inflammation research 2026;19:555053
Schisandrin B enhances autophagy and random flaps survival through the PPARG-mediated PI3K/AKT/mTOR signaling pathway.
Li Y, Zhang J, Yang J, Gao J, Jin Y, Zhang Y, Chen H, Cai L
Free radical biology & medicine 2026 May;248:92-108
Free radical biology & medicine 2026 May;248:92-108
PSAT1 inhibits mTORC1 activation by preventing Rag heterodimer formation in lung adenocarcinoma.
Liu Y, Cheng Z, Zhang J, Zhang Y, Zhao T, Sun L, Wen G, Han T, Wang J
Autophagy 2026 Mar;22(3):468-483
Autophagy 2026 Mar;22(3):468-483
Inhibition of ESCRT-III activates alternative pathways for protein degradation and secretion.
Fujiwara M, Sakai R, Takahashi M, Matsumoto G, Hashimoto T, Kabuta T
Neurochemistry international 2026 Jun;196:106153
Neurochemistry international 2026 Jun;196:106153
Licochalcone A promotes autophagy to ameliorate NAFLD by inhibiting the mTOR and regulating ULK1/Beclin1/VPS34 pathway.
Li J, Zhang D, Liu P, Fang R, Li Y, Zhu Y, Dong M, Xie S, Liu Y, Wu J, Zhu G, Han J
Journal of ethnopharmacology 2026 Jan 30;355(Pt B):120333
Journal of ethnopharmacology 2026 Jan 30;355(Pt B):120333
Bletilla striata polysaccharide induces autophagy through PI3K/AKT signaling pathway to promote the survival of cross-boundary flap in rats.
Yue Q, Zeng X, Yang M, Chen J, Liu L, Liu H
Frontiers in pharmacology 2025;16:1544932
Frontiers in pharmacology 2025;16:1544932
LZTR1 is a melanoma oncogene that promotes invasion and suppresses apoptosis.
Bacchiocchi A, Mak M, Khan ZM, Gong X, Sznol M, Na Z, Su H, Chan LH, Yan Q, Zhao D, Mortlock RD, Knight J, Slavoff SA, Halaban R
Oncogene 2025 Oct;44(41):3974-3984
Oncogene 2025 Oct;44(41):3974-3984
Transferrin receptor controls both autophagosome formation and closure via phosphatidylinositol 3-phosphate synthesis.
Puri C, Park SJ, Wrobel L, Rubinsztein DC
Developmental cell 2025 Oct 20;60(20):2715-2729.e8
Developmental cell 2025 Oct 20;60(20):2715-2729.e8
Macelignan Improves Functional Recovery After Spinal Cord Injury by Augmenting Autophagy via the AKT-mTOR-TFEB Signaling Pathway.
Zhu Y, Yang S, Su S, Huang Y, Chen Y, Liang H, Miao J, Wu Z, Li X, Xiao J, Wang X
Phytotherapy research : PTR 2025 May;39(5):2091-2109
Phytotherapy research : PTR 2025 May;39(5):2091-2109
Regulation of N-degron recognin-mediated autophagy by the SARS-CoV-2 PLpro ubiquitin deconjugase.
Ayala-Torres C, Liu J, Dantuma NP, Masucci MG
Autophagy 2025 May;21(5):1019-1038
Autophagy 2025 May;21(5):1019-1038
Kit-mediated autophagy suppression driven by a viral oncoprotein emerges as a crucial survival mechanism in Merkel cell carcinoma.
Shi H, Yang Y, Gao J, Kumar S, Xie H, Chen Z, Lyu J, Sihto H, Koljonen V, Vega-Rubin-de-Celis S, Vukojevic V, Farnebo F, Björnhagen V, Höög A, Juhlin CC, Lee L, Wickström M, Becker JC, Johnsen JI, Larsson C, Lui WO
Autophagy 2025 Jul;21(7):1523-1543
Autophagy 2025 Jul;21(7):1523-1543
MLKL-USP7-UBA52 signaling is indispensable for autophagy in brain through maintaining ubiquitin homeostasis.
Zhang Z, Chen S, Jun S, Xu X, Hong Y, Yang X, Zou L, Song YQ, Chen Y, Tu J
Autophagy 2025 Feb;21(2):424-446
Autophagy 2025 Feb;21(2):424-446
Astragalin inhibits neuronal excitability and activates neuronal autophagy in the ACC and LH of CFA mice to alleviate inflammatory pain and pain-related emotions.
Lin J, Zhang W, Wang S, Wang C, Zhang R, Yang Y, Zhou C, Zhang L, Tang P, Liu J, Jin X, Ma Y
International immunopharmacology 2025 Feb 20;148:114115
International immunopharmacology 2025 Feb 20;148:114115
Trehalose Rescues Postmenopausal Osteoporosis Induced by Ovariectomy through Alleviating Osteoblast Pyroptosis via Promoting Autophagy.
Hu X, Wang W, Chen X, Kong C, Zhao X, Wang Z, Zhang H, Lu S
Biomedicines 2024 Sep 29;12(10)
Biomedicines 2024 Sep 29;12(10)
Bunyavirus SFTSV NSs utilizes autophagy to escape the antiviral innate immune response.
Li ZM, Duan SH, Yu TM, Li B, Zhang WK, Zhou CM, Yu XJ
Autophagy 2024 Oct;20(10):2133-2145
Autophagy 2024 Oct;20(10):2133-2145
NEMO-Binding Domain/IKKγ Inhibitory Peptide Alleviates Neuronal Pyroptosis in Spinal Cord Injury by Inhibiting ASMase-Induced Lysosome Membrane Permeabilization.
Geng Y, Lou J, Wu J, Tao Z, Yang N, Kuang J, Wu Y, Zhang J, Xiang L, Shi J, Cai Y, Wang X, Chen J, Xiao J, Zhou K
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Oct;11(40):e2405759
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Oct;11(40):e2405759
Overcoming multi-drug resistance in SCLC: a synergistic approach with venetoclax and hydroxychloroquine targeting the lncRNA LYPLAL1-DT/BCL2/BECN1 pathway.
Li S, Lv J, Li Z, Zhang Q, Lu J, Huo X, Guo M, Liu X, Li C, Wang J, Shi H, Deng L, Chen Z, Du X
Molecular cancer 2024 Oct 31;23(1):243
Molecular cancer 2024 Oct 31;23(1):243
VD(3)/VDR attenuates bisphenol A-induced impairment in mouse Leydig cells via regulation of autophagy.
Wang L, Zhuang J, Xue Z, Lu H, Zeng W, Zhang T
Journal of food science 2024 Jun;89(6):3858-3870
Journal of food science 2024 Jun;89(6):3858-3870
Celastrol enhances the viability of random-pattern skin flaps by regulating autophagy through the AMPK-mTOR-TFEB axis.
Gu M, Li C, Deng Q, Chen X, Lei R
Phytotherapy research : PTR 2024 Jun;38(6):3020-3036
Phytotherapy research : PTR 2024 Jun;38(6):3020-3036
FGF-18 Protects the Injured Spinal cord in mice by Suppressing Pyroptosis and Promoting Autophagy via the AKT-mTOR-TRPML1 axis.
Li F, Cai T, Yu L, Yu G, Zhang H, Geng Y, Kuang J, Wang Y, Cai Y, Xiao J, Wang X, Ding J, Xu H, Ni W, Zhou K
Molecular neurobiology 2024 Jan;61(1):55-73
Molecular neurobiology 2024 Jan;61(1):55-73
Sesamin-mediated high expression of BECN2 ameliorates cartilage endplate degeneration by reducing autophagy and inflammation.
Zhang B, He Z, Guo J, Li F, Huang Z, Zheng W, Xing W, Li M, Zhu Y, Yang X
Aging 2024 Jan 26;16(2):1145-1160
Aging 2024 Jan 26;16(2):1145-1160
Ezrin inhibition alleviates oxidative stress and pyroptosis via regulating TRPML1-calcineurin axis mediated enhancement of autophagy in spinal cord injury.
Lou J, Jin M, Zhou C, Fan Y, Ni L, Mao Y, Shen H, Li J, Zhang H, Fu C, Mao X, Chen Y, Zhong J, Zhou K, Wang L, Wu J
Free radical biology & medicine 2024 Feb 20;212:133-148
Free radical biology & medicine 2024 Feb 20;212:133-148
Corynoxine triggers cell death via activating PP2A and regulating AKT-mTOR/GSK3β axes in NSCLC.
Hou G, Hu W, Sang Y, Gan X, Xu H, Hu Q, Cao X
Biochemical pharmacology 2024 Apr;222:116110
Biochemical pharmacology 2024 Apr;222:116110
Echovirus induces autophagy to promote viral replication via regulating mTOR/ULK1 signaling pathway.
Wu C, Zeng L, Yi W, Miao Y, Liu Y, Wang Q, Liu S, Peng G, Zheng Z, Xia J
Frontiers in immunology 2023;14:1162208
Frontiers in immunology 2023;14:1162208
Assessment of Autophagy Markers Suggests Increased Activity Following LVAD Therapy.
Martin TG, Juarros MA, Cleveland JC Jr, Bristow MR, Ambardekar AV, Buttrick PM, Leinwand LA
JACC. Basic to translational science 2023 Sep;8(9):1043-1056
JACC. Basic to translational science 2023 Sep;8(9):1043-1056
MARCH7-mediated ubiquitination decreases the solubility of ATG14 to inhibit autophagy.
Shi X, Wu W, Feng Z, Fan P, Shi R, Zhang X
Cell reports 2023 Sep 26;42(9):113045
Cell reports 2023 Sep 26;42(9):113045
Realgar-Induced Neurotoxicity: Crosstalk Between the Autophagic Flux and the p62-NRF2 Feedback Loop Mediates p62 Accumulation to Promote Apoptosis.
Feng R, Liu J, Yang Z, Yao T, Ye P, Li X, Zhang J, Jiang H
Molecular neurobiology 2023 Oct;60(10):6001-6017
Molecular neurobiology 2023 Oct;60(10):6001-6017
Rosuvastatin promotes survival of random skin flaps through AMPK-mTOR pathway-induced autophagy.
Ye H, Li F, Shen Y, Wu X, Zhao L, Zhang H, Yang J, Shui X
International immunopharmacology 2023 May;118:110059
International immunopharmacology 2023 May;118:110059
Sinomenine promotes flap survival by upregulating eNOS and eNOS-mediated autophagy via PI3K/AKT pathway.
Zhang D, Jin C, Han T, Chen J, Ali Raza M, Li B, Wang L, Yan H
International immunopharmacology 2023 Mar;116:109752
International immunopharmacology 2023 Mar;116:109752
Partial inhibition of class III PI3K VPS-34 ameliorates motor aging and prolongs health span.
Hu Z, Luo Y, Liu Y, Luo Y, Wang L, Gou S, Peng Y, Wei R, Jia D, Wang Y, Gao S, Zhang Y
PLoS biology 2023 Jul;21(7):e3002165
PLoS biology 2023 Jul;21(7):e3002165
Elamipretide alleviates pyroptosis in traumatically injured spinal cord by inhibiting cPLA2-induced lysosomal membrane permeabilization.
Zhang H, Chen Y, Li F, Wu C, Cai W, Ye H, Su H, He M, Yang L, Wang X, Zhou K, Ni W
Journal of neuroinflammation 2023 Jan 7;20(1):6
Journal of neuroinflammation 2023 Jan 7;20(1):6
Piperine attenuates the inflammation, oxidative stress, and pyroptosis to facilitate recovery from spinal cord injury via autophagy enhancement.
Zhang H, Wu C, Yu DD, Su H, Chen Y, Ni W
Phytotherapy research : PTR 2023 Feb;37(2):438-451
Phytotherapy research : PTR 2023 Feb;37(2):438-451
Cyclic helix B peptide alleviates proinflammatory cell death and improves functional recovery after traumatic spinal cord injury.
Xu Y, Geng Y, Wang H, Zhang H, Qi J, Li F, Hu X, Chen Y, Si H, Li Y, Wang X, Xu H, Kong J, Cai Y, Wu A, Ni W, Xiao J, Zhou K
Redox biology 2023 Aug;64:102767
Redox biology 2023 Aug;64:102767
Diallyl Trisulfide Enhances the Survival of Multiterritory Perforator Skin Flaps.
Dong C, Chen Z, Zhu L, Bsoul N, Wu H, Jiang J, Chen X, Lai Y, Yu G, Gu Y, Guo X, Gao W
Frontiers in pharmacology 2022;13:809034
Frontiers in pharmacology 2022;13:809034
An Experimental Study Reveals the Protective Effect of Autophagy against Realgar-Induced Liver Injury via Suppressing ROS-Mediated NLRP3 Inflammasome Pathway.
Yang J, Li J, Guo H, Zhang Y, Guo Z, Liu Y, Huo T
International journal of molecular sciences 2022 May 19;23(10)
International journal of molecular sciences 2022 May 19;23(10)
SHISA5/SCOTIN restrains spontaneous autophagy induction by blocking contact between the ERES and phagophores.
Lee JE, Kim N, Jung M, Mun JY, Yoo JY
Autophagy 2022 Jul;18(7):1613-1628
Autophagy 2022 Jul;18(7):1613-1628
Bunyavirus SFTSV exploits autophagic flux for viral assembly and egress.
Yan JM, Zhang WK, Yan LN, Jiao YJ, Zhou CM, Yu XJ
Autophagy 2022 Jul;18(7):1599-1612
Autophagy 2022 Jul;18(7):1599-1612
Cyclic helix B peptide promotes random-pattern skin flap survival via TFE3-mediated enhancement of autophagy and reduction of ROS levels.
Lou J, Zhang H, Qi J, Xu Y, Wang X, Jiang J, Hu X, Ni L, Cai Y, Wang X, Gao W, Xiao J, Zhou K
British journal of pharmacology 2022 Jan;179(2):301-321
British journal of pharmacology 2022 Jan;179(2):301-321
Phosphorylated STYK1 restrains the inhibitory role of EGFR in autophagy initiation and EGFR-TKIs sensitivity.
Zhou C, Dong X, Wang M, Qian X, Hu M, Liang K, Liang Y, Zhang R, Huang Y, Lyu H, Xiao S, Tang Y, Ali DW, Michalak M, Chen XZ, Tang J
Cell insight 2022 Aug;1(4):100045
Cell insight 2022 Aug;1(4):100045
Inhibition of autophagy potentiates the cytotoxicity of the irreversible FGFR1-4 inhibitor FIIN-2 on lung adenocarcinoma.
Jia X, Xin M, Xu J, Xiang X, Li X, Jiao Y, Wang L, Jiang J, Pang F, Zhang X, Zhang J
Cell death & disease 2022 Aug 30;13(8):750
Cell death & disease 2022 Aug 30;13(8):750
Paraquat Inhibits Autophagy Via Intensifying the Interaction Between HMGB1 and α-Synuclein.
Wang K, Zhang B, Zhang B, Wu K, Tian T, Yan W, Huang M
Neurotoxicity research 2022 Apr;40(2):520-529
Neurotoxicity research 2022 Apr;40(2):520-529
GDF-11 Protects the Traumatically Injured Spinal Cord by Suppressing Pyroptosis and Necroptosis via TFE3-Mediated Autophagy Augmentation.
Xu Y, Hu X, Li F, Zhang H, Lou J, Wang X, Wang H, Yin L, Ni W, Kong J, Wang X, Li Y, Zhou K, Xu H
Oxidative medicine and cellular longevity 2021;2021:8186877
Oxidative medicine and cellular longevity 2021;2021:8186877
Liraglutide, a TFEB-Mediated Autophagy Agonist, Promotes the Viability of Random-Pattern Skin Flaps.
Zhu X, Hu X, Lou J, Li J, Xu Y, Yu G, Wu C, Ding J, Gao W, Xiao J, Zhou K, Jia C
Oxidative medicine and cellular longevity 2021;2021:6610603
Oxidative medicine and cellular longevity 2021;2021:6610603
Betulinic acid inhibits pyroptosis in spinal cord injury by augmenting autophagy via the AMPK-mTOR-TFEB signaling pathway.
Wu C, Chen H, Zhuang R, Zhang H, Wang Y, Hu X, Xu Y, Li J, Li Y, Wang X, Xu H, Ni W, Zhou K
International journal of biological sciences 2021;17(4):1138-1152
International journal of biological sciences 2021;17(4):1138-1152
Curcumin promotes the survival of ischemic random skin flaps via autophagy.
Tu Z, Jiang X, Li Y, Yang S, Lin D, Shi Y, Mao C, Zhang X, Lin C
American journal of translational research 2021;13(3):1337-1351
American journal of translational research 2021;13(3):1337-1351
Pseudoginsenoside F11 Enhances the Viability of Random-Pattern Skin Flaps by Promoting TFEB Nuclear Translocation Through AMPK-mTOR Signal Pathway.
Zhou F, Zhang X, Jiang L, Li S, Chen Y, Wu J
Frontiers in pharmacology 2021;12:667524
Frontiers in pharmacology 2021;12:667524
The effects of mTOR or Vps34-mediated autophagy on methylmercury-induced neuronal apoptosis in rat cerebral cortex.
Ni L, Wei Y, Pan J, Li X, Xu B, Deng Y, Yang T, Liu W
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Sep;155:112386
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Sep;155:112386
OAB-14 Effectively Ameliorates the Dysfunction of the Endosomal-Autophagic-Lysosomal Pathway in APP/PS1 Transgenic Mice.
Guo X, Bao X, Wang X, Liu D, Liu P, Chi T, Ji X, Zheng Z, Chen G, Zou L
ACS chemical neuroscience 2021 Nov 3;12(21):3985-3993
ACS chemical neuroscience 2021 Nov 3;12(21):3985-3993
Targeting PP2A with lomitapide suppresses colorectal tumorigenesis through the activation of AMPK/Beclin1-mediated autophagy.
Zuo Q, Liao L, Yao ZT, Liu YP, Wang DK, Li SJ, Yin XF, He QY, Xu WW
Cancer letters 2021 Nov 28;521:281-293
Cancer letters 2021 Nov 28;521:281-293
Exenatide improves random-pattern skin flap survival via TFE3 mediated autophagy augment.
Li J, Chen H, Lou J, Bao G, Wu C, Lou Z, Wang X, Ding J, Li Z, Xiao J, Xu H, Gao W, Zhou K
Journal of cellular physiology 2021 May;236(5):3641-3659
Journal of cellular physiology 2021 May;236(5):3641-3659
Autophagy Alters Bladder Angiogenesis and Improves Bladder Hyperactivity in the Pathogenesis of Ketamine-Induced Cystitis in a Rat Model.
Lu JH, Wu YH, Juan TJ, Lin HY, Lin RJ, Chueh KS, Lee YC, Chang CY, Juan YS
Biology 2021 May 30;10(6)
Biology 2021 May 30;10(6)
VPS34 regulates dynamin to determine the endocytosis of mitochondria-targeted zinc oxide nanoparticles in human osteosarcoma cells.
Pan X, He G, Hai B, Liu Y, Bian L, Yong L, Zhang H, Yang C, Du C, Mao T, Ma Y, Jia F, Dou X, Zhai S, Liu X
Journal of materials chemistry. B 2021 Mar 21;9(11):2641-2655
Journal of materials chemistry. B 2021 Mar 21;9(11):2641-2655
Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes.
Tremel S, Ohashi Y, Morado DR, Bertram J, Perisic O, Brandt LTL, von Wrisberg MK, Chen ZA, Maslen SL, Kovtun O, Skehel M, Rappsilber J, Lang K, Munro S, Briggs JAG, Williams RL
Nature communications 2021 Mar 10;12(1):1564
Nature communications 2021 Mar 10;12(1):1564
IL-6 regulates autophagy and chemotherapy resistance by promoting BECN1 phosphorylation.
Hu F, Song D, Yan Y, Huang C, Shen C, Lan J, Chen Y, Liu A, Wu Q, Sun L, Xu F, Hu F, Chen L, Luo X, Feng Y, Huang S, Hu J, Wang G
Nature communications 2021 Jun 15;12(1):3651
Nature communications 2021 Jun 15;12(1):3651
Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response.
Wang W, Li J, Tan J, Wang M, Yang J, Zhang ZM, Li C, Basnakian AG, Tang HW, Perrimon N, Zhou Q
Nature communications 2021 Jan 20;12(1):476
Nature communications 2021 Jan 20;12(1):476
Autophagic elimination of ribosomes during spermiogenesis provides energy for flagellar motility.
Lei Y, Zhang X, Xu Q, Liu S, Li C, Jiang H, Lin H, Kong E, Liu J, Qi S, Li H, Xu W, Lu K
Developmental cell 2021 Aug 23;56(16):2313-2328.e7
Developmental cell 2021 Aug 23;56(16):2313-2328.e7
Protective autophagy attenuates soft substrate-induced apoptosis through ROS/JNK signaling pathway in breast cancer cells.
Chen Y, Li P, Peng Y, Xie X, Zhang Y, Jiang Y, Li T, Qin X, Li S, Yang H, Wu C, Zheng C, Zhu J, You F, Liu Y
Free radical biology & medicine 2021 Aug 20;172:590-603
Free radical biology & medicine 2021 Aug 20;172:590-603
Hydroxysafflor yellow A promotes multiterritory perforating flap survival: an experimental study.
Zhang C, Shao Z, Chen Z, Lin C, Hu S, Lou Z, Li J, Zheng X, Lin N, Gao W
American journal of translational research 2020;12(8):4781-4794
American journal of translational research 2020;12(8):4781-4794
Butylphthalide Inhibits Autophagy and Promotes Multiterritory Perforator Flap Survival.
Li B, Chen Z, Luo X, Zhang C, Chen H, Wang S, Zhao M, Ma H, Liu J, Cheng M, Yang Y, Yan H
Frontiers in pharmacology 2020;11:612932
Frontiers in pharmacology 2020;11:612932
Baicalein Attenuates Pyroptosis and Endoplasmic Reticulum Stress Following Spinal Cord Ischemia-Reperfusion Injury via Autophagy Enhancement.
Wu C, Xu H, Li J, Hu X, Wang X, Huang Y, Li Y, Sheng S, Wang Y, Xu H, Ni W, Zhou K
Frontiers in pharmacology 2020;11:1076
Frontiers in pharmacology 2020;11:1076
TFE3, a potential therapeutic target for Spinal Cord Injury via augmenting autophagy flux and alleviating ER stress.
Zhou K, Zheng Z, Li Y, Han W, Zhang J, Mao Y, Chen H, Zhang W, Liu M, Xie L, Zhang H, Xu H, Xiao J
Theranostics 2020;10(20):9280-9302
Theranostics 2020;10(20):9280-9302
Vps34 derived phosphatidylinositol 3-monophosphate modulates megakaryocyte maturation and proplatelet production through late endosomes/lysosomes.
Bertović I, Kurelić R, Milošević I, Bender M, Krauss M, Haucke V, Jurak Begonja A
Journal of thrombosis and haemostasis : JTH 2020 Jul;18(7):1756-1772
Journal of thrombosis and haemostasis : JTH 2020 Jul;18(7):1756-1772
LncRNA PVT1 promotes gemcitabine resistance of pancreatic cancer via activating Wnt/β-catenin and autophagy pathway through modulating the miR-619-5p/Pygo2 and miR-619-5p/ATG14 axes.
Zhou C, Yi C, Yi Y, Qin W, Yan Y, Dong X, Zhang X, Huang Y, Zhang R, Wei J, Ali DW, Michalak M, Chen XZ, Tang J
Molecular cancer 2020 Jul 29;19(1):118
Molecular cancer 2020 Jul 29;19(1):118
Metformin Promotes the Survival of Random-Pattern Skin Flaps by Inducing Autophagy via the AMPK-mTOR-TFEB signaling pathway.
Wu H, Ding J, Li S, Lin J, Jiang R, Lin C, Dai L, Xie C, Lin D, Xu H, Gao W, Zhou K
International journal of biological sciences 2019;15(2):325-340
International journal of biological sciences 2019;15(2):325-340
Protective effects of resveratrol on random-pattern skin flap survival: an experimental study.
Lin J, Lin R, Li S, Wu H, Ding J, Xiang G, Li S, Wang Y, Lin D, Gao W, Kong J, Xu H, Zhou K
American journal of translational research 2019;11(1):379-392
American journal of translational research 2019;11(1):379-392
Betulinic Acid Enhances the Viability of Random-Pattern Skin Flaps by Activating Autophagy.
Li J, Bao G, ALyafeai E, Ding J, Li S, Sheng S, Shen Z, Jia Z, Lin C, Zhang C, Lou Z, Xu H, Gao W, Zhou K
Frontiers in pharmacology 2019;10:1017
Frontiers in pharmacology 2019;10:1017
FGF21 augments autophagy in random-pattern skin flaps via AMPK signaling pathways and improves tissue survival.
Zhou K, Chen H, Lin J, Xu H, Wu H, Bao G, Li J, Deng X, Shui X, Gao W, Ding J, Xiao J, Xu H
Cell death & disease 2019 Nov 18;10(12):872
Cell death & disease 2019 Nov 18;10(12):872
TGF-β1 inhibits the autophagy of podocytes by activating mTORC1 in IgA nephropathy.
Mao X, Xu Z, Xu X, Zeng M, Zhao Z, Zhang Z, Ding X, Wu H
Experimental cell research 2019 Dec 1;385(1):111670
Experimental cell research 2019 Dec 1;385(1):111670
Salvianolic Acid B Promotes the Survival of Random-Pattern Skin Flaps in Rats by Inducing Autophagy.
Lin J, Lin R, Li S, Wu H, Ding J, Xiang G, Li S, Wang Y, Lin D, Gao W, Kong J, Xu H, Zhou K
Frontiers in pharmacology 2018;9:1178
Frontiers in pharmacology 2018;9:1178
MAP1B-LC1 prevents autophagosome formation by linking syntaxin 17 to microtubules.
Arasaki K, Nagashima H, Kurosawa Y, Kimura H, Nishida N, Dohmae N, Yamamoto A, Yanagi S, Wakana Y, Inoue H, Tagaya M
EMBO reports 2018 Aug;19(8)
EMBO reports 2018 Aug;19(8)
β-Arrestins promote podocyte injury by inhibition of autophagy in diabetic nephropathy.
Liu J, Li QX, Wang XJ, Zhang C, Duan YQ, Wang ZY, Zhang Y, Yu X, Li NJ, Sun JP, Yi F
Cell death & disease 2016 Apr 7;7(4):e2183
Cell death & disease 2016 Apr 7;7(4):e2183
Modification of BECN1 by ISG15 plays a crucial role in autophagy regulation by type I IFN/interferon.
Xu D, Zhang T, Xiao J, Zhu K, Wei R, Wu Z, Meng H, Li Y, Yuan J
Autophagy 2015 Apr 3;11(4):617-28
Autophagy 2015 Apr 3;11(4):617-28
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- PC-3 cells were subjected to SDS PAGE followed by western blot with 12452-1-AP(PIK3C3 antibody) at dilution of 1:400
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- Immunohistochemical of paraffin-embedded human heart using 12452-1-AP(PIK3C3 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- The VPS34 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human VPS34. This antibody recognizes human,mouse,rat antigen. The VPS34 antibody has been validated for the following applications: ELISA, WB, IHC analysis.