Antibody data

Product number
BS61336
Provider
Bioworld Technology, Inc
Product name
SRD5A1 polyclonal antibody
Provider product page
Bioworld Technology, Inc - BS61336
Antibody type
Polyclonal
Antigen
A synthetic peptide corresponding to residues in Human SRD5A1.
Description
Steroid 5Ï«-Reductase is an important enzyme in androgen physiology because it catalyzes the conversion of testosterone into the more potent 5Ï«-dihydro-testosterone, which mediates androgen effects on target tissues. The enzyme exists as two isoforms: type 1, which is expressed mainly in the skin; and type 2, which is expressed mainly in the prostate. In cultured human skin cells, 5Ï«-Reductase 1 shows heterogeneity of protein, and has different levels of transcriptional and translational expression. 5Ï«-Reductase 1 is expressed in all portions of the hair follicle, whereas 5Ï«-Reductase 2 is expressed only in mesenchymal portions. In addition, 5Ï«-Reductase 1 is mainly expressed in human breast carcinoma and may play a role in the in situ production and actions of the potent androgen 5Ï«-dihydrotestosterone, including inhibition of cancer cell proliferation in hormone-dependent human breast carcinoma. The 5Ï«-Reductase-3Ï«-hydroxysteroid dehydrogenase complex is present in the human brain, suggesting that the complex may be involved in the synthesis of neuroactive steroids or the catabolism of neurotoxic steroids.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Provider Type Product Number
- No reagents -