BS7927

antibody from Bioworld Technology, Inc

Targeting: AZU1 AZAMP, AZU, CAP37, HBP, HUMAZUR, NAZC

Western blot (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

BS7927

Provider

Bioworld Technology, Inc

Product name

AZU1 polyclonal antibody

Antibody type

Polyclonal

Antigen

Recombinant full length Human AZU1.

Description

Azurocidin is a multifunctional endotoxin-binding serine protease homolog that accumulates in azurophil granules during the promyelocytic stage of neutrophil differentiation. The human azurocidin gene maps to chromosome 19p13.3 and encodes a 251 amino acid protein. The genes encoding azurocidin, neutrophil elastase, and proteinase 3 are in a cluster located at the tip of the short arm of chromosome 19. Each of these three proteins are expressed coordinately and their protein products are packaged together into azurophil granules. When released from activated granulocytes, azurocidin potentiates bacterial uptake in monocytes and enhances the potential of microbial killing in monocytes and granulocytes. Azurocidin potentiates the LPS-induced release of proinflammatory cytokines (TNF-alpha, IL-1, and IL-6) from isolated human monocytes. In addition azurocidin induces Ca++-dependent cytoskeletal rearrangement and intercellular gap formation in endothelial-cell monolayers in vitro, and increases macromolecular efflux in microvessels in vivo. Selective inactivation of azurocidin prevents azurophil granule containing neutrophils from inducing endothelial hyper-permeability, suggesting that azurocidin plays a central role in neutrophil trafficking during inflammation.

Reactivity

Human

Host

Rabbit

Isotype

IgG

Vial size

100ul

Concentration

1 mg/ml

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.