Antibody data
- Antibody Data
- Antigen structure
- References [40]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunoprecipitation [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 12769-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12769-1-AP, RRID:AB_2122089
- Product name
- IFITM2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated IFITM2 antibody (Cat. #12769-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references TLR-mediated aggresome-like induced structures comprise antimicrobial peptides and attenuate intracellular bacterial survival.
IFITM1 enhances nonenveloped viral RNA replication by facilitating cholesterol transport to the Golgi.
Interferon-inducible phospholipids govern IFITM3-dependent endosomal antiviral immunity.
IFITM2 Presents Antiviral Response through Enhancing Type I IFN Signaling Pathway.
IFN-γ Triggered IFITM2 Expression to Induce Malignant Phenotype in Elderly GBM.
Inhibition of Arenavirus Entry and Replication by the Cell-Intrinsic Restriction Factor ZMPSTE24 Is Enhanced by IFITM Antiviral Activity.
Swine Interferon-Inducible Transmembrane Proteins Potently Inhibit African Swine Fever Virus Replication.
IFITM3 restricts virus-induced inflammatory cytokine production by limiting Nogo-B mediated TLR responses.
Interferon-Induced Transmembrane Proteins Inhibit Infection by the Kaposi's Sarcoma-Associated Herpesvirus and the Related Rhesus Monkey Rhadinovirus in a Cell-Specific Manner.
The Polybasic Cleavage Site in SARS-CoV-2 Spike Modulates Viral Sensitivity to Type I Interferon and IFITM2.
IFITM proteins inhibit the late step of feline foamy virus replication.
Host antiviral protein IFITM2 restricts pseudorabies virus replication.
Opposing activities of IFITM proteins in SARS-CoV-2 infection.
Role of rhesus macaque IFITM3(2) in simian immunodeficiency virus infection of macaques.
Interferon-Induced Transmembrane Proteins Mediate Viral Evasion in Acute and Chronic Hepatitis C Virus Infection.
Identifying key barriers in cationic polymer gene delivery to human T cells.
Role of MxB in Alpha Interferon-Mediated Inhibition of HIV-1 Infection.
Cyclosporine H Overcomes Innate Immune Restrictions to Improve Lentiviral Transduction and Gene Editing In Human Hematopoietic Stem Cells.
The Inhibition of HIV-1 Entry Imposed by Interferon Inducible Transmembrane Proteins Is Independent of Co-Receptor Usage.
pH Optimum of Hemagglutinin-Mediated Membrane Fusion Determines Sensitivity of Influenza A Viruses to the Interferon-Induced Antiviral State and IFITMs.
Antiviral Role of IFITM Proteins in African Swine Fever Virus Infection.
Resistance of Transmitted Founder HIV-1 to IFITM-Mediated Restriction.
IFITM Proteins Restrict HIV-1 Infection by Antagonizing the Envelope Glycoprotein.
Interferon-Induced Transmembrane Protein-Mediated Inhibition of Host Cell Entry of Ebolaviruses.
BAG3 promotes pancreatic ductal adenocarcinoma growth by activating stromal macrophages.
Human respiratory syncytial virus infection is inhibited by IFN-induced transmembrane proteins.
Primate lentiviruses are differentially inhibited by interferon-induced transmembrane proteins.
IFITM proteins inhibit entry driven by the MERS-coronavirus spike protein: evidence for cholesterol-independent mechanisms.
A novel mode of poxvirus superinfection exclusion that prevents fusion of the lipid bilayers of viral and cellular membranes.
IFITM proteins are incorporated onto HIV-1 virion particles and negatively imprint their infectivity.
G3BP1, G3BP2 and CAPRIN1 are required for translation of interferon stimulated mRNAs and are targeted by a dengue virus non-coding RNA.
IFITM proteins incorporated into HIV-1 virions impair viral fusion and spread.
TMPRSS2 activates the human coronavirus 229E for cathepsin-independent host cell entry and is expressed in viral target cells in the respiratory epithelium.
IFITM proteins restrict viral membrane hemifusion.
IFITM-2 and IFITM-3 but not IFITM-1 restrict Rift Valley fever virus.
IFITM proteins restrict antibody-dependent enhancement of dengue virus infection.
The IFITM proteins inhibit HIV-1 infection.
Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus.
Identification of five interferon-induced cellular proteins that inhibit west nile virus and dengue virus infections.
The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus.
Bhatnagar A, Chopra U, Raja S, Das KD, Mahalingam S, Chakravortty D, Srinivasula SM
Molecular biology of the cell 2024 Mar 1;35(3):ar34
Molecular biology of the cell 2024 Mar 1;35(3):ar34
IFITM1 enhances nonenveloped viral RNA replication by facilitating cholesterol transport to the Golgi.
Ishikawa-Sasaki K, Murata T, Sasaki J
PLoS pathogens 2023 May;19(5):e1011383
PLoS pathogens 2023 May;19(5):e1011383
Interferon-inducible phospholipids govern IFITM3-dependent endosomal antiviral immunity.
Unali G, Crivicich G, Pagani I, Abou-Alezz M, Folchini F, Valeri E, Matafora V, Reisz JA, Giordano AMS, Cuccovillo I, Butta GM, Donnici L, D'Alessandro A, De Francesco R, Manganaro L, Cittaro D, Merelli I, Petrillo C, Bachi A, Vicenzi E, Kajaste-Rudnitski A
The EMBO journal 2023 May 15;42(10):e112234
The EMBO journal 2023 May 15;42(10):e112234
IFITM2 Presents Antiviral Response through Enhancing Type I IFN Signaling Pathway.
Chen L, Li X, Deng Y, Bi Y, Yan Z, Yang Y, Zhang X, Li H, Xie J, Feng R
Viruses 2023 Mar 28;15(4)
Viruses 2023 Mar 28;15(4)
IFN-γ Triggered IFITM2 Expression to Induce Malignant Phenotype in Elderly GBM.
Liang T, Wang X, Wang Y, Ma W
Journal of molecular neuroscience : MN 2023 Dec;73(11-12):946-955
Journal of molecular neuroscience : MN 2023 Dec;73(11-12):946-955
Inhibition of Arenavirus Entry and Replication by the Cell-Intrinsic Restriction Factor ZMPSTE24 Is Enhanced by IFITM Antiviral Activity.
Stott-Marshall RJ, Foster TL
Frontiers in microbiology 2022;13:840885
Frontiers in microbiology 2022;13:840885
Swine Interferon-Inducible Transmembrane Proteins Potently Inhibit African Swine Fever Virus Replication.
Cai S, Zheng Z, Cheng J, Zhong L, Shao R, Zheng F, Lai Z, Ou J, Xu L, Zhou P, Lu G, Zhang G
Frontiers in immunology 2022;13:827709
Frontiers in immunology 2022;13:827709
IFITM3 restricts virus-induced inflammatory cytokine production by limiting Nogo-B mediated TLR responses.
Clement M, Forbester JL, Marsden M, Sabberwal P, Sommerville MS, Wellington D, Dimonte S, Clare S, Harcourt K, Yin Z, Nobre L, Antrobus R, Jin B, Chen M, Makvandi-Nejad S, Lindborg JA, Strittmatter SM, Weekes MP, Stanton RJ, Dong T, Humphreys IR
Nature communications 2022 Sep 8;13(1):5294
Nature communications 2022 Sep 8;13(1):5294
Interferon-Induced Transmembrane Proteins Inhibit Infection by the Kaposi's Sarcoma-Associated Herpesvirus and the Related Rhesus Monkey Rhadinovirus in a Cell-Specific Manner.
Hörnich BF, Großkopf AK, Dcosta CJ, Schlagowski S, Hahn AS
mBio 2021 Dec 21;12(6):e0211321
mBio 2021 Dec 21;12(6):e0211321
The Polybasic Cleavage Site in SARS-CoV-2 Spike Modulates Viral Sensitivity to Type I Interferon and IFITM2.
Winstone H, Lista MJ, Reid AC, Bouton C, Pickering S, Galao RP, Kerridge C, Doores KJ, Swanson CM, Neil SJD
Journal of virology 2021 Apr 12;95(9)
Journal of virology 2021 Apr 12;95(9)
IFITM proteins inhibit the late step of feline foamy virus replication.
Kim J, Shin CG
Animal cells and systems 2020 Sep 15;24(5):282-288
Animal cells and systems 2020 Sep 15;24(5):282-288
Host antiviral protein IFITM2 restricts pseudorabies virus replication.
Xie J, Bi Y, Xu S, Han Y, Idris A, Zhang H, Li X, Bai J, Zhang Y, Feng R
Virus research 2020 Oct 2;287:198105
Virus research 2020 Oct 2;287:198105
Opposing activities of IFITM proteins in SARS-CoV-2 infection.
Shi G, Kenney AD, Kudryashova E, Zhang L, Hall-Stoodley L, Robinson RT, Kudryashov DS, Compton AA, Yount JS
bioRxiv : the preprint server for biology 2020 Aug 11;
bioRxiv : the preprint server for biology 2020 Aug 11;
Role of rhesus macaque IFITM3(2) in simian immunodeficiency virus infection of macaques.
Winkler M, Gärtner S, Markus L, Hoffmann M, Nehlmeier I, Krawczak M, Sauermann U, Pöhlmann S
PloS one 2019;14(11):e0224082
PloS one 2019;14(11):e0224082
Interferon-Induced Transmembrane Proteins Mediate Viral Evasion in Acute and Chronic Hepatitis C Virus Infection.
Wrensch F, Ligat G, Heydmann L, Schuster C, Zeisel MB, Pessaux P, Habersetzer F, King BJ, Tarr AW, Ball JK, Winkler M, Pöhlmann S, Keck ZY, Foung SKH, Baumert TF
Hepatology (Baltimore, Md.) 2019 Nov;70(5):1506-1520
Hepatology (Baltimore, Md.) 2019 Nov;70(5):1506-1520
Identifying key barriers in cationic polymer gene delivery to human T cells.
Olden BR, Cheng E, Cheng Y, Pun SH
Biomaterials science 2019 Feb 26;7(3):789-797
Biomaterials science 2019 Feb 26;7(3):789-797
Role of MxB in Alpha Interferon-Mediated Inhibition of HIV-1 Infection.
Xu B, Pan Q, Liang C
Journal of virology 2018 Sep 1;92(17)
Journal of virology 2018 Sep 1;92(17)
Cyclosporine H Overcomes Innate Immune Restrictions to Improve Lentiviral Transduction and Gene Editing In Human Hematopoietic Stem Cells.
Petrillo C, Thorne LG, Unali G, Schiroli G, Giordano AMS, Piras F, Cuccovillo I, Petit SJ, Ahsan F, Noursadeghi M, Clare S, Genovese P, Gentner B, Naldini L, Towers GJ, Kajaste-Rudnitski A
Cell stem cell 2018 Dec 6;23(6):820-832.e9
Cell stem cell 2018 Dec 6;23(6):820-832.e9
The Inhibition of HIV-1 Entry Imposed by Interferon Inducible Transmembrane Proteins Is Independent of Co-Receptor Usage.
Yu J, Liu SL
Viruses 2018 Aug 7;10(8)
Viruses 2018 Aug 7;10(8)
pH Optimum of Hemagglutinin-Mediated Membrane Fusion Determines Sensitivity of Influenza A Viruses to the Interferon-Induced Antiviral State and IFITMs.
Gerlach T, Hensen L, Matrosovich T, Bergmann J, Winkler M, Peteranderl C, Klenk HD, Weber F, Herold S, Pöhlmann S, Matrosovich M
Journal of virology 2017 Jun 1;91(11)
Journal of virology 2017 Jun 1;91(11)
Antiviral Role of IFITM Proteins in African Swine Fever Virus Infection.
Muñoz-Moreno R, Cuesta-Geijo MÁ, Martínez-Romero C, Barrado-Gil L, Galindo I, García-Sastre A, Alonso C
PloS one 2016;11(4):e0154366
PloS one 2016;11(4):e0154366
Resistance of Transmitted Founder HIV-1 to IFITM-Mediated Restriction.
Foster TL, Wilson H, Iyer SS, Coss K, Doores K, Smith S, Kellam P, Finzi A, Borrow P, Hahn BH, Neil SJD
Cell host & microbe 2016 Oct 12;20(4):429-442
Cell host & microbe 2016 Oct 12;20(4):429-442
IFITM Proteins Restrict HIV-1 Infection by Antagonizing the Envelope Glycoprotein.
Yu J, Li M, Wilkins J, Ding S, Swartz TH, Esposito AM, Zheng YM, Freed EO, Liang C, Chen BK, Liu SL
Cell reports 2015 Oct 6;13(1):145-156
Cell reports 2015 Oct 6;13(1):145-156
Interferon-Induced Transmembrane Protein-Mediated Inhibition of Host Cell Entry of Ebolaviruses.
Wrensch F, Karsten CB, Gnirß K, Hoffmann M, Lu K, Takada A, Winkler M, Simmons G, Pöhlmann S
The Journal of infectious diseases 2015 Oct 1;212 Suppl 2(Suppl 2):S210-8
The Journal of infectious diseases 2015 Oct 1;212 Suppl 2(Suppl 2):S210-8
BAG3 promotes pancreatic ductal adenocarcinoma growth by activating stromal macrophages.
Rosati A, Basile A, D'Auria R, d'Avenia M, De Marco M, Falco A, Festa M, Guerriero L, Iorio V, Parente R, Pascale M, Marzullo L, Franco R, Arra C, Barbieri A, Rea D, Menichini G, Hahne M, Bijlsma M, Barcaroli D, Sala G, di Mola FF, di Sebastiano P, Todoric J, Antonucci L, Corvest V, Jawhari A, Firpo MA, Tuveson DA, Capunzo M, Karin M, De Laurenzi V, Turco MC
Nature communications 2015 Nov 2;6:8695
Nature communications 2015 Nov 2;6:8695
Human respiratory syncytial virus infection is inhibited by IFN-induced transmembrane proteins.
Zhang W, Zhang L, Zan Y, Du N, Yang Y, Tien P
The Journal of general virology 2015 Jan;96(Pt 1):170-182
The Journal of general virology 2015 Jan;96(Pt 1):170-182
Primate lentiviruses are differentially inhibited by interferon-induced transmembrane proteins.
Qian J, Le Duff Y, Wang Y, Pan Q, Ding S, Zheng YM, Liu SL, Liang C
Virology 2015 Jan 1;474:10-8
Virology 2015 Jan 1;474:10-8
IFITM proteins inhibit entry driven by the MERS-coronavirus spike protein: evidence for cholesterol-independent mechanisms.
Wrensch F, Winkler M, Pöhlmann S
Viruses 2014 Sep 26;6(9):3683-98
Viruses 2014 Sep 26;6(9):3683-98
A novel mode of poxvirus superinfection exclusion that prevents fusion of the lipid bilayers of viral and cellular membranes.
Laliberte JP, Moss B
Journal of virology 2014 Sep 1;88(17):9751-68
Journal of virology 2014 Sep 1;88(17):9751-68
IFITM proteins are incorporated onto HIV-1 virion particles and negatively imprint their infectivity.
Tartour K, Appourchaux R, Gaillard J, Nguyen XN, Durand S, Turpin J, Beaumont E, Roch E, Berger G, Mahieux R, Brand D, Roingeard P, Cimarelli A
Retrovirology 2014 Nov 25;11:103
Retrovirology 2014 Nov 25;11:103
G3BP1, G3BP2 and CAPRIN1 are required for translation of interferon stimulated mRNAs and are targeted by a dengue virus non-coding RNA.
Bidet K, Dadlani D, Garcia-Blanco MA
PLoS pathogens 2014 Jul;10(7):e1004242
PLoS pathogens 2014 Jul;10(7):e1004242
IFITM proteins incorporated into HIV-1 virions impair viral fusion and spread.
Compton AA, Bruel T, Porrot F, Mallet A, Sachse M, Euvrard M, Liang C, Casartelli N, Schwartz O
Cell host & microbe 2014 Dec 10;16(6):736-47
Cell host & microbe 2014 Dec 10;16(6):736-47
TMPRSS2 activates the human coronavirus 229E for cathepsin-independent host cell entry and is expressed in viral target cells in the respiratory epithelium.
Bertram S, Dijkman R, Habjan M, Heurich A, Gierer S, Glowacka I, Welsch K, Winkler M, Schneider H, Hofmann-Winkler H, Thiel V, Pöhlmann S
Journal of virology 2013 Jun;87(11):6150-60
Journal of virology 2013 Jun;87(11):6150-60
IFITM proteins restrict viral membrane hemifusion.
Li K, Markosyan RM, Zheng YM, Golfetto O, Bungart B, Li M, Ding S, He Y, Liang C, Lee JC, Gratton E, Cohen FS, Liu SL
PLoS pathogens 2013 Jan;9(1):e1003124
PLoS pathogens 2013 Jan;9(1):e1003124
IFITM-2 and IFITM-3 but not IFITM-1 restrict Rift Valley fever virus.
Mudhasani R, Tran JP, Retterer C, Radoshitzky SR, Kota KP, Altamura LA, Smith JM, Packard BZ, Kuhn JH, Costantino J, Garrison AR, Schmaljohn CS, Huang IC, Farzan M, Bavari S
Journal of virology 2013 Aug;87(15):8451-64
Journal of virology 2013 Aug;87(15):8451-64
IFITM proteins restrict antibody-dependent enhancement of dengue virus infection.
Chan YK, Huang IC, Farzan M
PloS one 2012;7(3):e34508
PloS one 2012;7(3):e34508
The IFITM proteins inhibit HIV-1 infection.
Lu J, Pan Q, Rong L, He W, Liu SL, Liang C
Journal of virology 2011 Mar;85(5):2126-37
Journal of virology 2011 Mar;85(5):2126-37
Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus.
Huang IC, Bailey CC, Weyer JL, Radoshitzky SR, Becker MM, Chiang JJ, Brass AL, Ahmed AA, Chi X, Dong L, Longobardi LE, Boltz D, Kuhn JH, Elledge SJ, Bavari S, Denison MR, Choe H, Farzan M
PLoS pathogens 2011 Jan 6;7(1):e1001258
PLoS pathogens 2011 Jan 6;7(1):e1001258
Identification of five interferon-induced cellular proteins that inhibit west nile virus and dengue virus infections.
Jiang D, Weidner JM, Qing M, Pan XB, Guo H, Xu C, Zhang X, Birk A, Chang J, Shi PY, Block TM, Guo JT
Journal of virology 2010 Aug;84(16):8332-41
Journal of virology 2010 Aug;84(16):8332-41
The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus.
Brass AL, Huang IC, Benita Y, John SP, Krishnan MN, Feeley EM, Ryan BJ, Weyer JL, van der Weyden L, Fikrig E, Adams DJ, Xavier RJ, Farzan M, Elledge SJ
Cell 2009 Dec 24;139(7):1243-54
Cell 2009 Dec 24;139(7):1243-54
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- MCF7 cells were subjected to SDS PAGE followed by western blot with 12769-1-AP(IFITM2 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The IFITM2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human IFITM2. This antibody recognizes human antigen. The IFITM2 antibody has been validated for the following applications: ELISA, IP, IHC, WB, IF analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-IFITM2 (IP:12769-1-AP, 3ug; Detection:12769-1-AP 1:300) with HepG2 cells lysate 1720ug.
- Sample type
- cell line