MA1-35910

antibody from Invitrogen Antibodies
Targeting: MCAM CD146, HEMCAM, MelCAM, METCAM, MUC18
Provider product page for MA1-35910
Flow cytometry

Antibody data

Product number
MA1-35910 - Provider product page
Provider
Invitrogen Antibodies
Product name
CD146 Monoclonal Antibody (OJ79c), FITC
Antibody type
Monoclonal
Antigen
Recombinant full-length protein
Description
OJ79c recognizes human Cell surface glycoprotein MUC18, also known as CD146, Cell surface glycoprotein P1H12, Melanoma cell adhesion molecule (MCAM) or S-endo 1 endothelial-associated antigen. CD146 is a 646 amino acid single pass type 1 transmembrane glycoprotein with a calculated molecular mass of ~72 kDa. However due to extensive N-linked glycosylation CD146 migrates in polyacrylamide gels with an apparent molecular mass of ~118 kDa. CD146 is a member of the immunoglobulin superfamily bearing 2 V-type Ig-like and 3 C-type Ig-like domains. CD146 is expressed by all endothelial cells and by melanoma cells and appears to act as an adhesion molecule (UniProt: P43121). Expression in melanoma may be linked to tumor progression (Lehmann et al. 1989).Mouse anti Human CD146 antibody, clone OJ79c is highly expressed on pericytes and has been utilized for the identification of perivascular mesenchymal precursor cells from cardiac muscle using flow cytometry (Chen et al. 2014).
Reactivity
Human, Canine, Porcine
Host
Mouse
Conjugate
Green dye
Isotype
IgG
Antibody clone number
OJ79c
Vial size
100 µg
Concentration
0.1 mg/mL
Storage
4° C, store in dark
MCAM protein structure - MA1-35910 shown in red.