Antibody data
- Antibody Data
- Antigen structure
- References [1]
- Comments [0]
- Validations [0]
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- Product number
- MA1-35910 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- CD146 Monoclonal Antibody (OJ79c), FITC
- Antibody type
- Monoclonal
- Antigen
- Recombinant full-length protein
- Description
- OJ79c recognizes human Cell surface glycoprotein MUC18, also known as CD146, Cell surface glycoprotein P1H12, Melanoma cell adhesion molecule (MCAM) or S-endo 1 endothelial-associated antigen. CD146 is a 646 amino acid single pass type 1 transmembrane glycoprotein with a calculated molecular mass of ~72 kDa. However due to extensive N-linked glycosylation CD146 migrates in polyacrylamide gels with an apparent molecular mass of ~118 kDa. CD146 is a member of the immunoglobulin superfamily bearing 2 V-type Ig-like and 3 C-type Ig-like domains. CD146 is expressed by all endothelial cells and by melanoma cells and appears to act as an adhesion molecule (UniProt: P43121). Expression in melanoma may be linked to tumor progression (Lehmann et al. 1989).Mouse anti Human CD146 antibody, clone OJ79c is highly expressed on pericytes and has been utilized for the identification of perivascular mesenchymal precursor cells from cardiac muscle using flow cytometry (Chen et al. 2014).
- Reactivity
- Human, Canine, Porcine
- Host
- Mouse
- Conjugate
- Green dye
- Isotype
- IgG
- Antibody clone number
- OJ79c
- Vial size
- 100 µg
- Concentration
- 0.1 mg/mL
- Storage
- 4° C, store in dark
Submitted references Spatial and temporal characterization of endometrial mesenchymal stem-like cells activity during the menstrual cycle.
Xu S, Chan RWS, Ng EHY, Yeung WSB
Experimental cell research 2017 Jan 1;350(1):184-189
Experimental cell research 2017 Jan 1;350(1):184-189
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