ABIN968422

antibody from antibodies-online

Targeting: MCAM CD146, HEMCAM, MelCAM, METCAM, MUC18

Western blot (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Antibody Data

Product number

ABIN968422

Provider

antibodies-online

Product name

anti-Melanoma Cell Adhesion Molecule (MCAM) (AA 104-305) antibody

Antibody type

Monoclonal

Antigen

Human MCAM

Reactivity

Human

Host

Mouse

Isotype

IgG

Antibody clone number

1

Vial size

50 µg

Concentration

250 µg/ml

Storage

Store undiluted at -20° C.

References

Submitted references

Activation of human endothelial cells via S-endo-1 antigen (CD146) stimulates the tyrosine phosphorylation of focal adhesion kinase p125(FAK).

Anfosso F, Bardin N, Francès V, Vivier E, Camoin-Jau L, Sampol J, Dignat-George F
The Journal of biological chemistry 1998 Oct 9;273(41):26852-6

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Loss of AP-2 results in up-regulation of MCAM/MUC18 and an increase in tumor growth and metastasis of human melanoma cells.

Jean D, Gershenwald JE, Huang S, Luca M, Hudson MJ, Tainsky MA, Bar-Eli M
The Journal of biological chemistry 1998 Jun 26;273(26):16501-8

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Expression of MCAM/MUC18 by human melanoma cells leads to increased tumor growth and metastasis.

Xie S, Luca M, Huang S, Gutman M, Reich R, Johnson JP, Bar-Eli M
Cancer research 1997 Jun 1;57(11):2295-303

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MUC18, a marker of tumor progression in human melanoma, shows sequence similarity to the neural cell adhesion molecules of the immunoglobulin superfamily.

Lehmann JM, Riethmüller G, Johnson JP
Proceedings of the National Academy of Sciences of the United States of America 1989 Dec;86(24):9891-5