APBA2

The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. [provided by RefSeq, Jul 2017]

Description

Amyloid beta precursor protein binding family A member 2

Tissue specificity

Tissue enhanced (brain, lymphoid tissue)

Subcell location

Golgi apparatus

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transporters

Chromosome

15:q13.1 (28884483 - 29118315)

Ensembl ID

ENSG00000034053  (ver. 103.38)

Orthologs

Mouse Apba2: ENSMUSG00000030519

UniProt

Q99767

neXtProt

NX_Q99767

Human splice variants
Mouse splice variants