RA0132

antibody from Oursmab
Targeting: CD74 DHLAG
Provider product page for RA0132
Western blot
ELISA
Immunocytochemistry
Flow cytometry
Functional assay

Antibody data

Product number
RA0132 - Provider product page
Provider
Oursmab
Product name
Milatuzumab (Biosimilar Reference Antibody) (CD74)
Antibody type
Monoclonal
Description
Milatuzumab (also known as hLL1 or IMMU-115) is a humanized monoclonal antibody that targets CD74, the invariant chain associated with major histocompatibility complex class II (MHC-II). CD74 is a transmembrane glycoprotein that functions as a chaperone for MHC-II and also acts as a signaling receptor for the cytokine macrophage migration inhibitory factor (MIF). It is highly expressed on B cells, monocytes, macrophages, and many B-cell malignancies. Milatuzumab was developed as a potential therapy for B-cell non-Hodgkin lymphoma (NHL) and multiple myeloma, with mechanisms including direct signaling-mediated apoptosis and antibody-dependent cellular cytotoxicity (ADCC). It has also been investigated in autoimmune diseases due to CD74's role in immune cell activation.
Reactivity
Human
Isotype
IgG
Vial size
100 ¦Ìg,1 mg,5 mg,10 mg,25 mg,50 mg,100 mg
Concentration
Bottled at the concentration indicated on the vial.
Storage
Store at -20¡ãC or -80¡ãC. Avoid repeated freeze.
CD74 protein structure - RA0132 shown in red.