DMAB7580

antibody from Creative Diagnostics

Targeting: HRAS HRAS1

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Antibody Data

Product number

DMAB7580

Provider

Creative Diagnostics

Proper citation

Creative Diagnostics Cat#DMAB7580, RRID:AB_2396600

Product name

Anti-Pan-Ras monoclonal antibody, clone EXQ

Antibody type

Monoclonal

Description

Ras is the name given to a family of related proteins found inside cells, including human cells. All Ras protein family members belong to a class of protein called small GTPase, and are involved in transmitting signals within cells (cellular signal transduction). Ras is the prototypical member of the Ras superfamily of proteins, which are all related in 3D structure and regulate diverse cell behaviours.The clinically most notable members of the Ras subfamily are HRAS, KRAS and NRAS, mainly for being implicated in many types of cancer. GTPaseKRas also known as V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog and KRAS, is a protein that in humans is encoded by the KRAS gene. Like other members of the Ras family, the KRAS protein is a GTPase and is an early player in many signal transduction pathways. KRAS is usually tethered to cell membranes because of the presence of an isoprenyl group on its C-terminus. The protein product of the normal KRAS gene performs an essential function in normal tissue signaling, and the mutation of a KRAS gene is an essential step in the development of many cancers. NRAS is an enzyme that in humans is encoded by the NRAS gene. It was discovered by researchers at the Institute of Cancer Research, funded by the Imperial Cancer Research Fund (now Cancer Research UK), and named NRAS, for its initial identification in human neuroblastoma cells. GTPaseHRas also known as transforming protein p21 is an enzyme that in humans is encoded by the HRAS gene. The HRAS gene is located on the short (p) arm of chromosome 11 at position 15.5, from base pair 522,241 to base pair 525,549

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

EXQ

Vial size

100 _g

Storage

-20°C. Do not freeze