Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- BS5829 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- NRL polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide, corresponding to amino acids 42-87 of Human NRL.
- Description
- Nrl (neural retina leucine zipper) is a member of the Maf family of transcription factors, which characteristically contain a highly conserved basic leucine zipper (bZIP)-DNA binding motif. Both Nrl and c-Maf preferentially bind to T-MARE sites and are implicated in a wide variety of developmental and physiologic roles. The Maf-Nrl subfamily regulates the expression of cell type-specific genes in tissues of the hematopoietic system, cerebellum and developing hindbrain. Maf and Nrl proteins bind an extended AP-1-like sequence and can form heterodimers with Fos and Jun transcription factors. In retinal cells and photoreceptor cells, Nrl promotes the expression of rhodopsin through binding to the Nrl response element present in the rhodopsin promoter. Nrl is expressed throughout the developing central and peripheral nervous system during neuronal differentiation, and its expression is restricted to neocortex, brainstem and retinal neurons during adulthood.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
- Main image
- Experimental details
- Western blot (WB) analysis of NRL pAb at 1:500 dilutionLane1:HEK293T cell lysateLane2:sp2/0 cell lysateLane3:PC12 cell lysate