CABT-B8747

antibody from Creative Diagnostics

Targeting: WFS1 DFNA14, DFNA38, DFNA6, DIDMOAD, WFS

Western blot (Recommended by provider)

Antibody Data

Product number

CABT-B8747

Provider

Creative Diagnostics

Product name

Anti-WFS1 polyclonal antibody

Antibody type

Polyclonal

Description

Wolfram syndrome protein (WFS1) is an 890 amino acid protein that contains a cytoplasmic N-terminal domain, followed by nine-transmembrane domains and a luminal C-terminal domain. WFS1 is predominantly localized to the endoplasmic reticulum (ER) and its expression is induced in response to ER stress, partially through transcriptional activation. Research studies have shown that mutations in the WFS1 gene lead to Wolfram syndrome, an autosomal recessive neurodegenerative disorder defined by young-onset, non-immune, insulin-dependent diabetes mellitus and progressive optic atrophy.

Reactivity

Human, Mouse

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Storage

Store at -20°C. Avoid freeze / thaw cycles.