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- Antibody Data
- Antigen structure
- References [29]
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- Product number
- 26995-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- WFS1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated WFS1 antibody (Cat. #26995-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references WFS1-related isolated diabetes induced by a WFS1 missense mutation: focus on the isolated diabetes phenotype.
Synaptic Alterations Are Preceding the Axonal Loss in Optic Atrophy of Wolfram Syndrome Mouse Model.
Entorhinal Cortex Wolframin-1-expressing neurons propagate tau to CA1 neurons and impair hippocampal memory.
Proteomic profiling of pseudorabies virus-infected PK-15 cells based on 4D label free analysis.
Astrocytes in the medial entorhinal cortex are required for spatial exploration.
Early trigeminal and sensory impairment and lysosomal dysfunction in accurate models of Wolfram syndrome.
MyoD1 localization at the nuclear periphery is mediated by association of WFS1 with active enhancers.
Do wolframin, P-glycoprotein, and GRP78/BiP cooperate to alter the response of L1210 cells to endoplasmic reticulum stress or drug sensitivity?
Entorhinal cortex layer III Adgrl2 expression controls topographical circuit connectivity required for sequence learning.
Astrocyte-mediated regulation of BLA(WFS1) neurons alleviates risk-assessment deficits in DISC1-N mice.
ER calcium depletion as a key driver for impaired ER-to-mitochondria calcium transfer and mitochondrial dysfunction in Wolfram syndrome.
Acetylcholine synergizes with netrin-1 to drive persistent firing in the entorhinal cortex.
Mouse hippocampal CA1 VIP interneurons detect novelty in the environment and support recognition memory.
Histone methyltransferase SETD2 is required for proper hippocampal lamination and neuronal maturation.
The differentiation and integration of the hippocampal dorsoventral axis are controlled by two nuclear receptor genes.
KDM2B regulates hippocampal morphogenesis by transcriptionally silencing Wnt signaling in neural progenitors.
Phosphoproteomics Reveals the Wolframin-Calcium Axis as an Important Pathogenic Signaling Node in Primary Aldosteronism.
A proximity labeling strategy enables proteomic analysis of inter-organelle membrane contacts.
Hippocampus shapes cortical sensory output and novelty coding through a direct feedback circuit.
Loss of Function of WFS1 Causes ER Stress-Mediated Inflammation in Pancreatic Beta-Cells.
Wolframin is a novel regulator of tau pathology and neurodegeneration.
The fasciola cinereum subregion of the hippocampus is important for the acquisition of visual contextual memory.
WFS1 protein expression correlates with clinical progression of optic atrophy in patients with Wolfram syndrome.
Activation of the sigma-1 receptor chaperone alleviates symptoms of Wolfram syndrome in preclinical models.
Activity disruption causes degeneration of entorhinal neurons in a mouse model of Alzheimer's circuit dysfunction.
Wolfram syndrome 1b mutation suppresses Mauthner-cell axon regeneration via ER stress signal pathway.
Wolframin-1-expressing neurons in the entorhinal cortex propagate tau to CA1 neurons and impair hippocampal memory in mice.
WFS1 functions in ER export of vesicular cargo proteins in pancreatic β-cells.
Somatostatin interneurons activated by 5-HT(2A) receptor suppress slow oscillations in medial entorhinal cortex.
Huang M, Wei Q, Qin Y, Qin L, Shao Y, Wang S, Qu X, Yang T, Zhang M
Orphanet journal of rare diseases 2026 Mar 27;21(1)
Orphanet journal of rare diseases 2026 Mar 27;21(1)
Synaptic Alterations Are Preceding the Axonal Loss in Optic Atrophy of Wolfram Syndrome Mouse Model.
Gurram V, An W, Bimal S, Urano F
bioRxiv : the preprint server for biology 2026 Mar 25;
bioRxiv : the preprint server for biology 2026 Mar 25;
Entorhinal Cortex Wolframin-1-expressing neurons propagate tau to CA1 neurons and impair hippocampal memory.
Delpech JC, Kalavai SV, Pathak D, Ravula AR, Lad HV, Hays EC, Touch N, Rau A, Madore C, Medalla M, Luebke JI, Ikezu S, Ikezu T
bioRxiv : the preprint server for biology 2026 Feb 20;
bioRxiv : the preprint server for biology 2026 Feb 20;
Proteomic profiling of pseudorabies virus-infected PK-15 cells based on 4D label free analysis.
Wang S, Chen X, Luo H, Wang M, Liu J, Han Q
Veterinary research forum : an international quarterly journal 2025;16(3):141-147
Veterinary research forum : an international quarterly journal 2025;16(3):141-147
Astrocytes in the medial entorhinal cortex are required for spatial exploration.
Huang M, Yang Z, Wang H, Yang S, Li J, Liang S, Teng T, Yang C, Gong M, Qin H, Li X, Chen X, Liao X, Zhang K
Cell reports 2025 Sep 23;44(9):116173
Cell reports 2025 Sep 23;44(9):116173
Early trigeminal and sensory impairment and lysosomal dysfunction in accurate models of Wolfram syndrome.
Tulva K, Pirajev A, Zeb A, Aksoy AE, Bello A, Lee B, Guðjónsson BF, Helgadottir SB, Jagomäe T, García-Llorca A, Eysteinsson T, Jürgenson M, Plaas M, Vasar E, Kaasik A, Hickey MA
Experimental neurology 2025 Mar;385:115099
Experimental neurology 2025 Mar;385:115099
MyoD1 localization at the nuclear periphery is mediated by association of WFS1 with active enhancers.
Georgiou K, Sarigol F, Nimpf T, Knapp C, Filipczak D, Foisner R, Naetar N
Nature communications 2025 Mar 17;16(1):2614
Nature communications 2025 Mar 17;16(1):2614
Do wolframin, P-glycoprotein, and GRP78/BiP cooperate to alter the response of L1210 cells to endoplasmic reticulum stress or drug sensitivity?
Kurekova S, Pavlikova L, Seres M, Bohacova V, Spaldova J, Breier A, Sulova Z
Cancer cell international 2025 Feb 7;25(1):35
Cancer cell international 2025 Feb 7;25(1):35
Entorhinal cortex layer III Adgrl2 expression controls topographical circuit connectivity required for sequence learning.
Donohue JD, Blanton C, Chen A, Ahmad A, Liu ED, Saab L, Kaur R, Yang W, Anderson GR
Translational psychiatry 2025 Aug 8;15(1):272
Translational psychiatry 2025 Aug 8;15(1):272
Astrocyte-mediated regulation of BLA(WFS1) neurons alleviates risk-assessment deficits in DISC1-N mice.
Zhou X, Xiao Q, Liu Y, Chen S, Xu X, Zhang Z, Hong Y, Shao J, Chen Y, Chen Y, Wang L, Yang F, Tu J
Neuron 2024 Jul 3;112(13):2197-2217.e7
Neuron 2024 Jul 3;112(13):2197-2217.e7
ER calcium depletion as a key driver for impaired ER-to-mitochondria calcium transfer and mitochondrial dysfunction in Wolfram syndrome.
Liiv M, Vaarmann A, Safiulina D, Choubey V, Gupta R, Kuum M, Janickova L, Hodurova Z, Cagalinec M, Zeb A, Hickey MA, Huang YL, Gogichaishvili N, Mandel M, Plaas M, Vasar E, Loncke J, Vervliet T, Tsai TF, Bultynck G, Veksler V, Kaasik A
Nature communications 2024 Jul 21;15(1):6143
Nature communications 2024 Jul 21;15(1):6143
Acetylcholine synergizes with netrin-1 to drive persistent firing in the entorhinal cortex.
Glasgow SD, Fisher TAJ, Wong EW, Lançon K, Feighan KM, Beamish IV, Gibon J, Séguéla P, Ruthazer ES, Kennedy TE
Cell reports 2024 Feb 27;43(2):113812
Cell reports 2024 Feb 27;43(2):113812
Mouse hippocampal CA1 VIP interneurons detect novelty in the environment and support recognition memory.
Tamboli S, Singh S, Topolnik D, El Amine Barkat M, Radhakrishnan R, Guet-McCreight A, Topolnik L
Cell reports 2024 Apr 23;43(4):114115
Cell reports 2024 Apr 23;43(4):114115
Histone methyltransferase SETD2 is required for proper hippocampal lamination and neuronal maturation.
Hu G, Zheng Y, Zhang B, Zhao C, Xu L, Wei J, Jing J, Liu Y, Zeng T, Zhou Y
Molecular biology of the cell 2024 Apr 1;35(4):ar54
Molecular biology of the cell 2024 Apr 1;35(4):ar54
The differentiation and integration of the hippocampal dorsoventral axis are controlled by two nuclear receptor genes.
Yang X, Wan R, Liu Z, Feng S, Yang J, Jing N, Tang K
eLife 2023 Sep 26;12
eLife 2023 Sep 26;12
KDM2B regulates hippocampal morphogenesis by transcriptionally silencing Wnt signaling in neural progenitors.
Zhang B, Zhao C, Shen W, Li W, Zheng Y, Kong X, Wang J, Wu X, Zeng T, Liu Y, Zhou Y
Nature communications 2023 Oct 14;14(1):6489
Nature communications 2023 Oct 14;14(1):6489
Phosphoproteomics Reveals the Wolframin-Calcium Axis as an Important Pathogenic Signaling Node in Primary Aldosteronism.
Ma L, Yang S, Yang Y, Chen X, Yang J, He Y, Cheng Q, Li J, Kang B, Tang S, Zhang A, Shu X, Li X, Shen H, Jing Y, Song Y, Li Q, Hu J
Hypertension (Dallas, Tex. : 1979) 2023 May;80(5):995-1010
Hypertension (Dallas, Tex. : 1979) 2023 May;80(5):995-1010
A proximity labeling strategy enables proteomic analysis of inter-organelle membrane contacts.
Zhou M, Kong B, Zhang X, Xiao K, Lu J, Li W, Li M, Li Z, Ji W, Hou J, Xu T
iScience 2023 Jul 21;26(7):107159
iScience 2023 Jul 21;26(7):107159
Hippocampus shapes cortical sensory output and novelty coding through a direct feedback circuit.
Butola T, Hernández Frausto M, Blankvoort S, Flatset MS, Peng L, Elmaleh M, Hairston A, Hussain F, Clopath C, Kentros C, Basu J
Research square 2023 Aug 23;
Research square 2023 Aug 23;
Loss of Function of WFS1 Causes ER Stress-Mediated Inflammation in Pancreatic Beta-Cells.
Morikawa S, Blacher L, Onwumere C, Urano F
Frontiers in endocrinology 2022;13:849204
Frontiers in endocrinology 2022;13:849204
Wolframin is a novel regulator of tau pathology and neurodegeneration.
Chen S, Acosta D, Li L, Liang J, Chang Y, Wang C, Fitzgerald J, Morrison C, Goulbourne CN, Nakano Y, Villegas NCH, Venkataraman L, Brown C, Serrano GE, Bell E, Wemlinger T, Wu M, Kokiko-Cochran ON, Popovich P, Flowers XE, Honig LS, Vonsattel JP, Scharre DW, Beach TG, Ma Q, Kuret J, Kõks S, Urano F, Duff KE, Fu H
Acta neuropathologica 2022 May;143(5):547-569
Acta neuropathologica 2022 May;143(5):547-569
The fasciola cinereum subregion of the hippocampus is important for the acquisition of visual contextual memory.
Park SB, Lim HY, Lee EY, Yoo SW, Jung HS, Lee E, Sun W, Lee I
Progress in neurobiology 2022 Mar;210:102217
Progress in neurobiology 2022 Mar;210:102217
WFS1 protein expression correlates with clinical progression of optic atrophy in patients with Wolfram syndrome.
Hu K, Zatyka M, Astuti D, Beer N, Dias RP, Kulkarni A, Ainsworth J, Wright B, Majander A, Yu-Wai-Man P, Williams D, Barrett T
Journal of medical genetics 2022 Jan;59(1):65-74
Journal of medical genetics 2022 Jan;59(1):65-74
Activation of the sigma-1 receptor chaperone alleviates symptoms of Wolfram syndrome in preclinical models.
Crouzier L, Danese A, Yasui Y, Richard EM, Liévens JC, Patergnani S, Couly S, Diez C, Denus M, Cubedo N, Rossel M, Thiry M, Su TP, Pinton P, Maurice T, Delprat B
Science translational medicine 2022 Feb 9;14(631):eabh3763
Science translational medicine 2022 Feb 9;14(631):eabh3763
Activity disruption causes degeneration of entorhinal neurons in a mouse model of Alzheimer's circuit dysfunction.
Zhao R, Grunke SD, Wood CA, Perez GA, Comstock M, Li MH, Singh AK, Park KW, Jankowsky JL
eLife 2022 Dec 5;11
eLife 2022 Dec 5;11
Wolfram syndrome 1b mutation suppresses Mauthner-cell axon regeneration via ER stress signal pathway.
Wang Z, Wang X, Shi L, Cai Y, Hu B
Acta neuropathologica communications 2022 Dec 17;10(1):184
Acta neuropathologica communications 2022 Dec 17;10(1):184
Wolframin-1-expressing neurons in the entorhinal cortex propagate tau to CA1 neurons and impair hippocampal memory in mice.
Delpech JC, Pathak D, Varghese M, Kalavai SV, Hays EC, Hof PR, Johnson WE, Ikezu S, Medalla M, Luebke JI, Ikezu T
Science translational medicine 2021 Sep 15;13(611):eabe8455
Science translational medicine 2021 Sep 15;13(611):eabe8455
WFS1 functions in ER export of vesicular cargo proteins in pancreatic β-cells.
Wang L, Liu H, Zhang X, Song E, Wang Y, Xu T, Li Z
Nature communications 2021 Nov 30;12(1):6996
Nature communications 2021 Nov 30;12(1):6996
Somatostatin interneurons activated by 5-HT(2A) receptor suppress slow oscillations in medial entorhinal cortex.
de Filippo R, Rost BR, Stumpf A, Cooper C, Tukker JJ, Harms C, Beed P, Schmitz D
eLife 2021 Mar 31;10
eLife 2021 Mar 31;10
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