Antibody data

Product number
NB100-63601 - Provider product page
Provider
Novus Biologicals
Proper citation
Novus Cat#NB100-63601, RRID:AB_2281008
Product name
Rat Monoclonal LAG-3 Antibody
Antibody type
Monoclonal
Description
Protein G purified. NB100-63601 recognizes murine lymphocyte activation gene-3 (LAG-3), a 70kD activation-induced cell surface molecule that is also referred to as CD223. Murine CD223 is expressed on activated CD4 positive and CD8 positive alpha/beta T lymphocytes and a subset of natural killer (NK) cells. CD223 binds to MHC class II molecules with high affinity and is reported to negatively regulate T cell homeostasis and T cell expansion. Clone C9B7W recognizes an epitope within the D2 domain of CD223. The antibody is reported to block the in vitro function of murine LAG-3 but studies suggest that the antibody does not block binding of LAG-3 to MHC class II (1). 1. Workman, C.J. et al. (2002) Phenotypic analysis of the murine CD4-related glycoprotein, CD223 (LAG-3). Eur J Immunol. 32 (8): 2255-63
Reactivity
Mouse
Host
Rat
Isotype
IgG
Vial size
0.125 mg
Concentration
1.0 mg/ml
Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
LAG3 protein structure - NB100-63601 shown in red.