ALX-804-806B-C100

antibody from Enzo Life Sciences

Targeting: LAG3 CD223

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Antibody Data

Product number

ALX-804-806B-C100

Provider

Enzo Life Sciences

Proper citation

Enzo Life Sciences Cat#ALX-804-806B-C100, RRID:AB_2051748

Product name

LAG-3 (human) monoclonal antibody (17B4) (biotin conjugate)

Antibody type

Monoclonal

Antigen

Synthetic peptide

Description

Purified from concentrated hybridoma tissue culture supernatant by Protein A Sepharoseª CL-4B Flow Fast Column.

Reactivity

Human

Host

Mouse

Conjugate

Biotin

Isotype

IgG

Antibody clone number

17B4

Vial size

100 μg

Storage

-20°C

Handling

Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20¡C.

References

Submitted references

Human lymphocyte activation gene-3 molecules expressed by activated T cells deliver costimulation signal for dendritic cell activation.

Casati C, Camisaschi C, Novellino L, Mazzocchi A, Triebel F, Rivoltini L, Parmiani G, Castelli C
Journal of immunology (Baltimore, Md. : 1950) 2008 Mar 15;180(6):3782-8

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A soluble lymphocyte activation gene-3 (sLAG-3) protein as a prognostic factor in human breast cancer expressing estrogen or progesterone receptors.

Triebel F, Hacene K, Pichon MF
Cancer letters 2006 Apr 8;235(1):147-53

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The negative regulatory function of the lymphocyte-activation gene-3 co-receptor (CD223) on human T cells.

Maçon-Lemaître L, Triebel F
Immunology 2005 Jun;115(2):170-8

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Immunological mechanisms elicited at the tumour site by lymphocyte activation gene-3 (LAG-3) versus IL-12: sharing a common Th1 anti-tumour immune pathway.

Di Carlo E, Cappello P, Sorrentino C, D'Antuono T, Pellicciotta A, Giovarelli M, Forni G, Musiani P, Triebel F
The Journal of pathology 2005 Jan;205(1):82-91

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T Lymphocytes infiltrating various tumour types express the MHC class II ligand lymphocyte activation gene-3 (LAG-3): role of LAG-3/MHC class II interactions in cell-cell contacts.

Demeure CE, Wolfers J, Martin-Garcia N, Gaulard P, Triebel F
European journal of cancer (Oxford, England : 1990) 2001 Sep;37(13):1709-18

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CD3/TCR complex-associated lymphocyte activation gene-3 molecules inhibit CD3/TCR signaling.

Hannier S, Tournier M, Bismuth G, Triebel F
Journal of immunology (Baltimore, Md. : 1950) 1998 Oct 15;161(8):4058-65

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Characterization of the major histocompatibility complex class II binding site on LAG-3 protein.

Huard B, Mastrangeli R, Prigent P, Bruniquel D, Donini S, El-Tayar N, Maigret B, Dréano M, Triebel F
Proceedings of the National Academy of Sciences of the United States of America 1997 May 27;94(11):5744-9

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Cellular expression and tissue distribution of the human LAG-3-encoded protein, an MHC class II ligand.

Huard B, Gaulard P, Faure F, Hercend T, Triebel F
Immunogenetics 1994;39(3):213-7

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Characterization of the lymphocyte activation gene 3-encoded protein. A new ligand for human leukocyte antigen class II antigens.

Baixeras E, Huard B, Miossec C, Jitsukawa S, Martin M, Hercend T, Auffray C, Triebel F, Piatier-Tonneau D
The Journal of experimental medicine 1992 Aug 1;176(2):327-37