20989-1-AP

antibody from Proteintech Group

Targeting: PDX1 IDX-1, IPF1, MODY4, PDX-1, STF-1

Provider product page for 20989-1-AP

Western blot

ELISA

Antibody data

Antibody Data
Antigen structure
References [26]
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Product number: 20989-1-AP - Provider product page
Provider: Proteintech Group
Product name: PDX1 antibody
Antibody type: Polyclonal
Description: PDX1 antibody (Cat. #20989-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

PDX1 protein structure - 20989-1-AP shown in red.

Submitted references SIRT1 Regulates Iron Metabolism to Attenuate β-Cell Dedifferentiation by Inhibiting FoxO1 Acetylation.

Li T, Ma R, Tang W, Zheng Y, Lv S, Liu Y, Wang L, Ding Y
Biological trace element research 2026 Jan;204(1):453-465

Identification of RBX1 as a regulator of LIPT1 transcription and its role in copper-induced cell death in GBM cells.

Zeng J, Liu J, Hua S, Liu S, Tong S, Zhang J, Mungur R, Chen S, Feng J, Ding C
Scientific reports 2026 Jan 31;16(1):6837

TAT-PBX1 Reverses Hyperglycemia Through β-Cell Regeneration and Functional Restoration in an STZ-Induced Diabetic Model.

Meng X, Zhao Z, Zhang X, Guo R, Yang S, Mao S, Zong Z, Liu J
Pharmaceuticals (Basel, Switzerland) 2026 Jan 1;19(1)

Ophiopogonin D improves pancreatic islet cell dedifferentiation to treat diabetes by regulating the GRP78/ROS/PDX1 signaling pathway.

Sun H, Tan R, Sun Y, Li Y, Xie Y, Zhang C, Song J, Zhu W, Zhou J, Deng C, Mei M
Frontiers in pharmacology 2025;16:1563201

Bifidobacterium longum subsp. longum B-53 Alleviated Abnormalities of Glycolipid Metabolism and Oxidative Stress in T2DM Mice Through Regulating Gut Microbiota and GLP-1 Secretion.

Chen J, Zhang L, Cheng Z, Zhang Y, Li X, Zheng S, Zhang N, Li B, Liu F, Jiao Y
Journal of agricultural and food chemistry 2025 Sep 24;73(38):24169-24186

Unraveling the Role of MDK-SDC4 Interaction in Pancreatic Cancer-Associated New-Onset Diabetes by Single-Cell Transcriptomic Analysis.

Feng Z, Lou J, Lin C, Yu H, Tu Y, Gong J, Li X, Wu Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(39):e09987

Epigallocatechin gallate improves insulin sensitivity in rats experiencing catch-up growth after being small for gestational age by upregulating PDX1 expression.

Wang Y, Wu X, Chen L, Mao S
Translational pediatrics 2025 Oct 31;14(10):2437-2447

Urodele amphibian newt bridges the missing link in evo-devo of the pancreas.

Morozumi R, Okamoto K, Enomoto E, Tsukamoto Y, Kyakuno M, Suzuki N, Tazawa I, Furuno N, Ogino H, Kamei Y, Matsunami M, Shigenobu S, Suzuki K, Uemasu H, Namba N, Hayashi T
Developmental dynamics : an official publication of the American Association of Anatomists 2025 Jul;254(7):812-828

Single Low-Dose Ionizing Radiation Transiently Enhances Rat RIN-m5F Cell Function via the ROS/p38 MAPK Pathway Without Inducing Cell Damage.

Zhang J, Dai K, An R, Wang C, Zhou X, Tian Z, Liao Z
Antioxidants (Basel, Switzerland) 2025 Jan 21;14(2)

NLRP3 inflammasome activation and disruption of IRS-1/PI3K/AKT signaling: Potential mechanisms of arsenic-induced pancreatic beta cells dysfunction in rats.

Liu Y, Wang W, Liang B, Zou Z, Zhang A
Ecotoxicology and environmental safety 2025 Jan 1;289:117504

A novel covalent inhibitor alleviates type 2 diabetes mellitus by restraining GSK-3β.

Zhang S, Zhao F, Pan C, Wang Y, Yang Z, Yang J, Meng Y, Lv S, Huang J, Dong L, Li L, Dong Y
Biochemical pharmacology 2025 Dec;242(Pt 2):117205

Generation of a human induced pluripotent stem cell line overexpressing CCL22 with islet cells differentiation potential.

Jinliang D, Fang B, Xiaofeng Z, Xiaoshun H, Anbin H
Stem cell research 2024 Mar;75:103302

Glutathione Induces Keap1 S-Glutathionylation and Mitigates Oscillating Glucose-Induced β-Cell Dysfunction by Activating Nrf2.

Chen X, Zhou Q, Chen H, Bai J, An R, Zhang K, Zhang X, An H, Zhang J, Wang Y, Li M
Antioxidants (Basel, Switzerland) 2024 Mar 27;13(4)

EndoC-βH3 pseudoislets are suitable for intraportal transplantation in diabetic mice.

Zhou M, Linn T, Petry SF
Islets 2024 Dec 31;16(1):2406041

Angiotensin (1-7) reverses glucose-induced islet β cell dedifferentiation by Wnt/β-catenin/FoxO1 signalling pathway.

Guo D, He J, Guo H, Song G, Peng L, An M, Wang C
Endokrynologia Polska 2023;74(5):544-552

Human umbilical cord-derived mesenchymal stem cells alleviate oxidative stress-induced islet impairment via the Nrf2/HO-1 axis.

Liu P, Cao B, Zhou Y, Zhang H, Wang C
Journal of molecular cell biology 2023 Nov 27;15(5)

Lycopene ameliorates islet function and down-regulates the TLR4/MyD88/NF-κB pathway in diabetic mice and Min6 cells.

Liu Y, Tian Y, Dai X, Liu T, Zhang Y, Wang S, Shi H, Yin J, Xu T, Zhu R, Zhang Y, Zhao D, Gao S, Wang XD, Wang L, Zhang D
Food & function 2023 Jun 6;14(11):5090-5104

Dual-core coaxial bioprinting of double-channel constructs with a potential for perfusion and interaction of cells.

Yu Y, Xie R, He Y, Zhao F, Zhang Q, Wang W, Zhang Y, Hu J, Luo D, Peng W
Biofabrication 2022 May 26;14(3)

Targeted Polymeric Nanoparticles Based on Mangiferin for Enhanced Protection of Pancreatic β-Cells and Type 1 Diabetes Mellitus Efficacy.

Wang M, Zhang Z, Huo Q, Wang M, Sun Y, Liu H, Chang J, He B, Liang Y
ACS applied materials & interfaces 2022 Mar 9;14(9):11092-11103

SARS-CoV-2 in the pancreas and the impaired islet function in COVID-19 patients.

Ji N, Zhang M, Ren L, Wang Y, Hu B, Xiang J, Gong Y, Wu C, Qu G, Ding W, Yin Z, Li S, Wang Z, Zhou L, Chen X, Ma Y, Tang J, Liu Y, Liu L, Huang M
Emerging microbes & infections 2022 Dec;11(1):1115-1125

Three-dimensional cell-culture platform based on hydrogel with tunable microenvironmental properties to improve insulin-secreting function of MIN6 cells.

Zhang M, Yan S, Xu X, Yu T, Guo Z, Ma M, Zhang Y, Gu Z, Feng Y, Du C, Wan M, Hu K, Han X, Gu N
Biomaterials 2021 Mar;270:120687

Tectorigenin enhances PDX1 expression and protects pancreatic β-cells by activating ERK and reducing ER stress.

Yao X, Li K, Liang C, Zhou Z, Wang J, Wang S, Liu L, Yu CL, Song ZB, Bao YL, Zheng LH, Sun Y, Wang G, Huang Y, Yi J, Sun L, Li Y
The Journal of biological chemistry 2020 Sep 11;295(37):12975-12992

Screening active components from Rubus amabilis for pancreatic β-cells protection.

Sun M, Zhu T, Tong J, Caidan R, Wang K, Kai G, Zhang W, Ru L, Pengcuo J, Tong L
Pharmaceutical biology 2020 Dec;58(1):674-685

Effects of Neuropeptide Substance P on Proliferation and β-Cell Differentiation of Adult Pancreatic Ductal Cells.

Zhang N, Gao D, Liu Y, Ji S, Sha L
Frontiers in neuroscience 2018;12:806

The Synergy of Two Factors on Insulin Expression.

Luo Y, Xu Y, Wang ZY, Li X, Xing WB, Zhang TC
Cellular reprogramming 2018 Feb;20(1):49-54

Hepatitis B X-interacting protein promotes the formation of the insulin gene-transcribing protein complex Pdx-1/Neurod1 in animal pancreatic β-cells.

Li H, Wang Z, Li Y, Fang R, Wang H, Shi H, Zhang X, Zhang W, Ye L
The Journal of biological chemistry 2018 Feb 9;293(6):2053-2065

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