BS7989

antibody from Bioworld Technology, Inc
Targeting: PNPLA2 ATGL, desnutrin, FP17548, iPLA2zeta, TTS-2.2
Provider product page for BS7989
Western blot
Immunohistochemistry

Antibody data

Product number
BS7989 - Provider product page
Provider
Bioworld Technology, Inc
Product name
PNPLA2 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human PNPLA2.
Description
The Adiponutrin family members, which have been implicated in obesity and diabetes, consist of Adiponutrin (ADPN), GS1, GS2, GS2-like, PNPLA1, and adipose triglyceride lipase (ATGL), also designated Desnutrin or Patatin-like phospholipase domain-containing protein 2 (PLNPA2). AGTL is a 486-amino acid protein that is highly expressed in mouse and human adipose tissue. It contains a highly conserved 180-amino acid N-terminal patatin domain common to plant acyl-hydrolases with a glycine-rich region, an aspartate active site motif, and an active serine hydrolase motif. Along with hormone-sensitive lipase, ATGL catabolizes stored triglycerides in mammalian adipose tissue. The lipase activity of AGTL is dependent upon the presence of an activated serine residue. ADPN and ATGL are oppositely regulated by insulin, where upregulation of ATGl and downregulation of ADPN occurs when fasting.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
PNPLA2 protein structure - BS7989 shown in red.