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Learn55190-1-AP
antibody from Proteintech Group
Targeting: PNPLA2
ATGL, desnutrin, FP17548, iPLA2zeta, TTS-2.2
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- Antibody Data
- Antigen structure
- References [127]
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- Validations
- Western blot [1]
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- Product number
- 55190-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#55190-1-AP, RRID:AB_11182818
- Product name
- ATGL antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated ATGL antibody (Cat. #55190-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references NUDT7 Modulates the UBA52-SREBF1 Signaling Axis to Promote PRRSV Replication via Lipid Synthesis.
β3-adrenergic receptor agonist causes acute thermogenic metabolic crisis in ACSS1-K635Q knock-in mice.
Chronic intermittent hypoxia increases Parkinson's disease susceptibility via PPARα-mediated lipid droplet-mitochondrial dysfunction.
Polydatin Targets ACADVL to Combat Obesity by Promoting Adipocyte Browning and Activating Fatty Acid Oxidation.
N-acetylglucosamine ameliorates the transition from acute kidney injury to chronic kidney disease by reducing the accumulation of lipid droplets.
Hypoxia-inducible factor 1αa regulates lipid metabolism to coordinate adipocyte hypertrophy and hyperplasia in grass carp.
Lipophagy fuels phosphatidylcholine synthesis for Newcastle disease virus replication.
Monascus pilosus SWM-008-Fermented Red Mold Rice and Its Monascinol Ameliorate Non-Alcoholic Fatty Liver Disease via Activation of the AMPK-ATGL Pathway and Enrichment of Butyrate-Producing Bacteria.
Gastric bypass surgery improves lipid metabolism and mitochondrial function through the glutamate receptor Grin3a-mediated CaMKKβ/AMPK pathway in a rat model of type 2 diabetes.
Isomeranzin activates Gnas-AMPK signaling to drive white adipose browning and curb obesity in mice.
Integrating IDEAL-IQ Sequence with Mass Spectrometry Imaging for Profiling Lipid-Related Metabolic Reprogramming of Acute Kidney Injury.
Bone marrow-derived mesenchymal stem cells alleviate hepatic lipid metabolism disorders after scald injury: integrating liver transcriptome and metabolome.
Gut Microbiota-Derived Propionic Acid Mediates ApoA-I-Induced Amelioration of MASLD via Activation of GPR43-Ca(2+)-CAMKII-ATGL Hepatic Lipolysis.
Effects of Piperine on Obese and Lean Nonalcoholic Fatty Liver Disease in Mice.
PRMT3-mediated post-translational adaptation to fasting regulates metabolic flexibility.
Annexin A1 exacerbates islet stellate cell activation by regulating triglyceride catabolism via the PPARα/ACOX1/CYP4a pathway.
African swine fever virus hijacks lipolysis induced by chaperone-mediated autophagy to upregulate fatty acid β-oxidation and promote viral replication.
A new investigation of nonalcoholic fatty liver disease: Effects of hypoxia on mitochondrial function and lipid droplet autophagy.
PEDF Overexpression Ameliorates Cardiac Lipotoxicity in Diabetic Cardiomyopathy via Regulation of Energy Metabolism.
Identification of Biomarkers for Sepsis-Induced Acute Lung Injury Through Bioinformatics and Machine Learning Approaches, with Experimental Validation.
Circadian control of hepatic ischemia/reperfusion injury via HSD17B13-mediated autophagy in hepatocytes.
Vimentin intermediate filaments orchestrate DNA nonhomologous end joining repair and lipolysis after DNA damage.
NAT10-mediated N4-acetylcytidine modification in KLF9 mRNA promotes adipogenesis.
Mechanisms of metabolic-associated fatty liver disease induced by 48-week PCB138 exposure and theabrownin intervention.
Jiangtang Tiaozhi formula ameliorates MASLD by regulating liver ABCD2/PEX2/ATGL axis-mediated fatty acid metabolic reprogramming.
Betaine decreases hepatic lipid deposition through DNA 5 mC and RNA m(6)A methylation-mediated regulation of fatty acid metabolic genes expression in laying hens.
AAV9-mediated gene supplementation therapy prevents and rescues arrhythmogenic cardiomyopathy in Pnpla2-mutated mice.
Proinflammatory polarization of adipose tissue macrophages in cows with subclinical ketosis constitutes a critical driver of adipose tissue remodeling and inflammation.
A two-strata energy flux system driven by a stress hormone prioritizes cardiac energetics.
Chronic Waterborne Exposure to Polystyrene Microplastics Induces Kupffer Cell Polarization Imbalance and Hepatic Lipid Accumulation.
A galacturonan from sea buckthorn (Hippophae rhamnoides L.) berry modulates dyslipidemia by promoting hepatic lipolysis and mitochondrial oxidation.
Glia maturation factor-β deficiency improves insulin resistance by promoting CARM1-mediated lipid turnover.
TRIM59 deficiency aggravates HFD-induced obesity in mice associated with increased adipose tissue inflammation, lipid accumulation, and apoptosis.
Cetacean loss of the master adipose tissue regulator β(3)-adrenergic receptor may underlie their thick blubber and an Oligocene radiation and dispersal.
Cetacean-specific GPR12 mutation is functionally associated with blubber thickening.
1-Linoleoylglycerophosphocholine stimulates UCP1-dependent thermogenesis and mitochondrial respiration to combat obesity.
The cyclic peptide mallotumide A inhibits colon and breast cancer cell growth and motility by targeting cellular respiration and lipogenesis.
RAB18 deficiency disrupts lipid metabolism and autophagy in mice.
Arctiin, a lignan compound, enhances adipose tissue browning and energy expenditure by activating the adenosine A(2A) receptor.
Study on metabolic disorders in rat liver induced by different times after scalds.
Oral exposure to nanoplastics altered lipid profiles in mouse intestine.
Dicyclohexyl phthalate derails trophoblast function and lipid metabolism through NDRG1 by targeting PPARα:RXRα.
PRRSV Nsp4 induces ATGL protein degradation to promote viral replication and lipid droplet accumulation.
Human transmembrane protein 68 links triacylglycerol synthesis to membrane lipid homeostasis.
Rapamycin induced autophagy enhances lipid breakdown and ameliorates lipotoxicity in Atlantic salmon cells.
The lysosomal membrane protein LAMP2B mediates microlipophagy to target obesity-related disorders.
Clinicopathological-genetic features of neutral lipid storage disease with myopathy from a Chinese neuromuscular center.
cTAGE5 is essential for adipogenesis and adipose tissue development.
Polystyrene nanoplastics promote colitis-associated cancer by disrupting lipid metabolism and inducing DNA damage.
Effects of duration of high-fat diet on adipocyte hyperplasia in rat epididymis.
Intermittent fasting triggers interorgan communication to suppress hair follicle regeneration.
The cholesterol metabolite 25-hydroxycholesterol suppresses porcine deltacoronavirus via lipophagy inhibition and mTORC1 modulation.
SIRT6 Ameliorates Cancer Cachexia-Associated Adipose Wasting by Suppressing TNFR2 Signalling in Mice.
Trans 10, cis 12-conjugated linoleic acid in low concentration reduces while in high concentration enhances adipocyte metabolism but effectively improves hepatic steatosis of obese mice.
Liver ALKBH5 regulates glucose and lipid homeostasis independently through GCGR and mTORC1 signaling.
Isoliquiritigenin Ameliorates High-Fat Diet-Induced Obesity in Mice by Activating Brown Adipose Tissue.
Vitisin A Outperforms Cyanidin-3-O-Glucoside in Triglyceride Reduction by Modulating Hepatic Lipogenesis and Fatty Acid β-Oxidation.
Mdivi-1 promotes lipid droplets-mitochondria contact and ameliorates cardiac lipotoxicity in high-fat diet-fed mice.
NG-497 Alleviates Microglia-Mediated Neuroinflammation in a MTNR1A-Dependent Manner.
RGFP966 inhibits palmitic acid induced VSMCs phenotypic transition by targeting ATGL.
Loss of lipid droplet-mitochondria contacts confers protection against ethanol-induced cardiotoxicity.
Bushen Huoxue formula attenuates lipid accumulation evoking excessive autophagy in premature ovarian insufficiency rats and palmitic acid-challenged KGN cells by modulating lipid metabolism.
Lipolysis engages CD36 to promote ZBP1-mediated necroptosis-impairing lung regeneration in COPD.
Dahuang Huanglian Xiexin Decoction ameliorates obesity via modulating adipocyte differentiation and lipid degradation through inhibiting endoplasmic reticulum stress.
Pea Albumin Alleviates Oleic Acid-Induced Lipid Accumulation in LO2 Cells Through Modulating Lipid Metabolism and Fatty Acid Oxidation Pathways.
Contribution of impaired autophagy, mitochondrial dysfunction and abnormal lipolysis to epididymal aging in mice.
Diallyl disulfide alleviates hepatic steatosis by the conservative mechanism from fish to tetrapod: Augment Mfn2/Atgl-Mediated lipid droplet-mitochondria coupling.
Sestrin2 in POMC neurons modulates energy balance and obesity related metabolic disorders via mTOR signaling.
Transgenic female mice producing trans 10, cis 12-conjugated linoleic acid present excessive prostaglandin E2, adrenaline, corticosterone, glucagon, and FGF21.
Activation of lipophagy ameliorates cadmium-induced neural tube defects via reducing low density lipoprotein cholesterol levels in mouse placentas.
Lipolysis inhibition improves the survival of fat grafts through ameliorating lipotoxicity and inflammation.
Calmodulin Contributes to Lipolysis and Inflammatory Responses in Clinical Ketosis Cows through the TLR4/IKK/NF-κB Pathway.
Roles of pigment epithelium-derived factor in exercise-induced suppression of senescence and its impact on lung pathology in mice.
Pea Albumin Extracted from Pea (Pisum sativum L.) Seeds Ameliorates High-Fat-Diet-Induced Non-Alcoholic Fatty Liver Disease by Regulating Lipogenesis and Lipolysis Pathways.
Lipodystrophic gene Agpat2 deficiency aggravates hyperlipidemia and atherosclerosis in Ldlr(-/-) mice.
Dietary manganese supplementation decreases hepatic lipid deposition by regulating gene expression and enzyme activity involved in lipid metabolism in the liver of broilers.
FXR overexpression prevents hepatic steatosis through inhibiting AIM2 inflammasome activation in alcoholic liver disease.
CircITGB5 regulates the proliferation and adipogenic differentiation of chicken intramuscular preadipocytes through the miR-181b-5p/CPT1A axis.
Sleep deprivation induced fat accumulation in the visceral white adipose tissue by suppressing SIRT1/FOXO1/ATGL pathway activation.
Voluntary Wheel Running Reduces Cardiometabolic Risks in Female Offspring Exposed to Lifelong High-Fat, High-Sucrose Diet.
Hepatocyte-Specific PEX16 Abrogation in Mice Leads to Hepatocyte Proliferation, Alteration of Hepatic Lipid Metabolism, and Resistance to High-Fat Diet (HFD)-Induced Hepatic Steatosis and Obesity.
In Vitro Comparative Analysis of the Effect and Structure-Based Influencing Factors of Flavonols on Lipid Accumulation.
PM(2.5) exposure aggravates kidney damage by facilitating the lipid metabolism disorder in diabetic mice.
WTAP boosts lipid oxidation and induces diabetic cardiac fibrosis by enhancing AR methylation.
Miquelianin in Folium Nelumbinis extract promotes white-to-beige fat conversion via blocking AMPK/DRP1/mitophagy and modulating gut microbiota in HFD-fed mice.
Ablation of pigment epithelium-derived factor receptor (PEDF-R/Pnpla2) causes photoreceptor degeneration.
Sulfur mustard analog 2-chloroethyl ethyl sulfide increases triglycerides by activating DGAT1-dependent biogenesis and inhibiting PGC1ɑ-dependent fat catabolism in immortalized human bronchial epithelial cells.
Lycopene inhibits endothelial-to-mesenchymal transition of choroidal vascular endothelial cells in laser-induced mouse choroidal neovascularization.
5-HEPE reduces obesity and insulin resistance by promoting adipose tissue browning through GPR119/AMPK/PGC1α activation.
Mitigation of non-alcoholic steatohepatitis via recombinant Orosomucoid 2, an acute phase protein modulating the Erk1/2-PPARγ-Cd36 pathway.
Activation of Atg5-dependent placental lipophagy ameliorates cadmium-induced fetal growth restriction.
TRIM21 attenuates renal carcinoma lipogenesis and malignancy by regulating SREBF1 protein stability.
Knockout of ICAT in Adipose Tissue Alleviates Fibro-inflammation in Obese Mice.
Tumor-secreted GRP78 induces M2 polarization of macrophages by promoting lipid catabolism.
CircRNA-mediated regulation of brown adipose tissue adipogenesis.
Graphene oxide links alterations of anti-viral signaling pathways with lipid metabolism via suppressing TLR3 in vascular smooth muscle cells.
Human gingival mesenchymal stem cells improve movement disorders and tyrosine hydroxylase neuronal damage in Parkinson disease rats.
Pu-erh tea increases the metabolite Cinnabarinic acid to improve circadian rhythm disorder-induced obesity.
Aerobic exercise promotes the expression of ATGL and attenuates inflammation to improve hepatic steatosis via lncRNA SRA.
Baicalin ameliorates alcohol-induced hepatic steatosis by suppressing SREBP1c elicited PNPLA3 competitive binding to ATGL.
Endurance exercise-mediated metabolic reshuffle attenuates high-caloric diet-induced non-alcoholic fatty liver disease.
Phenotypic and genotypic changes in obesity and type 2 diabetes of male KK mice with aging.
Ginsenoside CK ameliorates hepatic lipid accumulation via activating the LKB1/AMPK pathway in vitro and in vivo.
FUS Mutation Causes Disordered Lipid Metabolism in Skeletal Muscle Associated with ALS.
Polyphyllin I improves myocardial damage in coronary artery disease via modulating lipid metabolism and myocardial apoptosis.
Microalgae oil from Schizochytrium sp. alleviates obesity and modulates gut microbiota in high-fat diet-fed mice.
Deficiency of WTAP in hepatocytes induces lipoatrophy and non-alcoholic steatohepatitis (NASH).
Lipid metabolism is involved in the association of rotavirus viroplasms with endoplasmic reticulum membranes.
Functionalized gadofullerene ameliorates impaired glycolipid metabolism in type 2 diabetic mice.
The vesicular transporter STX11 governs ATGL-mediated hepatic lipolysis and lipophagy.
Quantitative proteomic analysis identified differentially expressed proteins with tail/rump fat deposition in Chinese thin- and fat-tailed lambs.
Function of Chick Subcutaneous Adipose Tissue During the Embryonic and Posthatch Period.
Sulfated glucuronomannan hexasaccharide G6S1 enhanced lipolysis and lipophagy via PPARα pathway.
Exercise improves lipid droplet metabolism disorder through activation of AMPK-mediated lipophagy in NAFLD.
Degradation of Photoreceptor Outer Segments by the Retinal Pigment Epithelium Requires Pigment Epithelium-Derived Factor Receptor (PEDF-R).
Pigment epithelium-derived factor (PEDF) and derived peptides promote survival and differentiation of photoreceptors and induce neurite-outgrowth in amacrine neurons.
Myostatin suppresses adipogenic differentiation and lipid accumulation by activating crosstalk between ERK1/2 and PKA signaling pathways in porcine subcutaneous preadipocytes.
Single-cell RNA sequencing of preadipocytes reveals the cell fate heterogeneity induced by melatonin.
Inhibition of PAI-1 Promotes Lipolysis and Enhances Weight Loss in Obese Mice.
CD2-Associated Protein Contributes to Hepatitis C, Virus Propagation and Steatosis by Disrupting Insulin Signaling.
mRNA m(6)A plays opposite role in regulating UCP2 and PNPLA2 protein expression in adipocytes.
PEDF improves cardiac function in rats subjected to myocardial ischemia/reperfusion injury by inhibiting ROS generation via PEDF‑R.
miR-128-3p regulates 3T3-L1 adipogenesis and lipolysis by targeting Pparg and Sertad2.
GLP-1/GLP-1R Signaling in Regulation of Adipocyte Differentiation and Lipogenesis.
Loss of ABHD5 promotes the aggressiveness of prostate cancer cells.
Transcription regulator TRIP-Br2 mediates ER stress-induced brown adipocytes dysfunction.
Lycium barbarum polysaccharide attenuates high-fat diet-induced hepatic steatosis by up-regulating SIRT1 expression and deacetylase activity.
Yan Y, Li C, Zhang J, Li R, Yin B, Zhang S, Zhang Y, Zhang X, Han J, Huang J
International journal of biological sciences 2026;22(3):1590-1610
International journal of biological sciences 2026;22(3):1590-1610
β3-adrenergic receptor agonist causes acute thermogenic metabolic crisis in ACSS1-K635Q knock-in mice.
Chocron ES, Zhang D, Sumawi B, Schell J, Cruz D, Li G, Sreenivas P, Jiang H, Dong FF, Munkácsy E, Zhao S, Porras MAG, Gius D
International journal of biological sciences 2026;22(3):1070-1081
International journal of biological sciences 2026;22(3):1070-1081
Chronic intermittent hypoxia increases Parkinson's disease susceptibility via PPARα-mediated lipid droplet-mitochondrial dysfunction.
Zhai MR, Pan J, Wu ZH, He YY, Zhang KR, Ren L, Wang YR, Li YB, Gao J, Xiao L, Liu YH
Theranostics 2026;16(5):2466-2487
Theranostics 2026;16(5):2466-2487
Polydatin Targets ACADVL to Combat Obesity by Promoting Adipocyte Browning and Activating Fatty Acid Oxidation.
He W, Gu Y, Zhang F, Xiang Y, Fang Y, Cai J, Li W, Wang Z, Qin G, Li K, Gu X, Lin X, Ma L, Hou Y, Xiao X, Luo T
Phytotherapy research : PTR 2026 May;40(5):2417-2436
Phytotherapy research : PTR 2026 May;40(5):2417-2436
N-acetylglucosamine ameliorates the transition from acute kidney injury to chronic kidney disease by reducing the accumulation of lipid droplets.
Tang Z, Ou Z, Wan H, Tao M, Li X, Huang Y, Tan Q, Peng Q, Dong L, Zhao J
International immunopharmacology 2026 May 15;177:116463
International immunopharmacology 2026 May 15;177:116463
Hypoxia-inducible factor 1αa regulates lipid metabolism to coordinate adipocyte hypertrophy and hyperplasia in grass carp.
Wei M, Tian Z, Song L, Xue R, Li H, Ji H, Sun J
The Journal of biological chemistry 2026 Mar;302(3):111195
The Journal of biological chemistry 2026 Mar;302(3):111195
Lipophagy fuels phosphatidylcholine synthesis for Newcastle disease virus replication.
Yang M, Chen J, Su X, Kan X, Tan L, Song C, Qiu X, Liao Y, Yu S, Ding C, Sun Y
Autophagy 2026 Jun;22(6):1351-1368
Autophagy 2026 Jun;22(6):1351-1368
Monascus pilosus SWM-008-Fermented Red Mold Rice and Its Monascinol Ameliorate Non-Alcoholic Fatty Liver Disease via Activation of the AMPK-ATGL Pathway and Enrichment of Butyrate-Producing Bacteria.
Hsieh CP, Hsu YW, Pan TM, Lee CL
Molecular nutrition & food research 2026 Jan;70(1):e70342
Molecular nutrition & food research 2026 Jan;70(1):e70342
Gastric bypass surgery improves lipid metabolism and mitochondrial function through the glutamate receptor Grin3a-mediated CaMKKβ/AMPK pathway in a rat model of type 2 diabetes.
Zhang L, Wang J, Tan B, Wang X, Luan Z
Diabetic medicine : a journal of the British Diabetic Association 2026 Jan;43(1):e70170
Diabetic medicine : a journal of the British Diabetic Association 2026 Jan;43(1):e70170
Isomeranzin activates Gnas-AMPK signaling to drive white adipose browning and curb obesity in mice.
Shi M, Ye Y, Hu L, Yan Y, Jiang S, Wang P, Li F, Ai M, Huang J, Yang L, Huang K, Liang M
EMBO molecular medicine 2026 Jan;18(1):55-90
EMBO molecular medicine 2026 Jan;18(1):55-90
Integrating IDEAL-IQ Sequence with Mass Spectrometry Imaging for Profiling Lipid-Related Metabolic Reprogramming of Acute Kidney Injury.
Zhao H, Chen Y, Guan B, Li J, Xu C, Guo J, Zhang L, Sun J, Zhao H, Zhang R
Small methods 2026 Jan;10(1):e01704
Small methods 2026 Jan;10(1):e01704
Bone marrow-derived mesenchymal stem cells alleviate hepatic lipid metabolism disorders after scald injury: integrating liver transcriptome and metabolome.
Chen Z, Yang Y, Shi X, Yang R, Fang W, Liang G, Li Y, Gao J, Ma L, Yang J, Pang R
Stem cell research & therapy 2026 Jan 2;17(1):1
Stem cell research & therapy 2026 Jan 2;17(1):1
Gut Microbiota-Derived Propionic Acid Mediates ApoA-I-Induced Amelioration of MASLD via Activation of GPR43-Ca(2+)-CAMKII-ATGL Hepatic Lipolysis.
Liu M, Wang Y, Huang H
International journal of molecular sciences 2026 Jan 1;27(1)
International journal of molecular sciences 2026 Jan 1;27(1)
Effects of Piperine on Obese and Lean Nonalcoholic Fatty Liver Disease in Mice.
Fan JB, Qin LQ, Ding L, Zhang L, Shao MM, Tong X, Xu JY
Journal of gastroenterology and hepatology 2026 Feb;41(2):753-762
Journal of gastroenterology and hepatology 2026 Feb;41(2):753-762
PRMT3-mediated post-translational adaptation to fasting regulates metabolic flexibility.
Huang Z, Liu X, Chen X, Zhou Y, Chen Q, Liu Y, Zhu H, Cheng K, Feng Y, Dong M, Song L, Wang L, Liu S, Shan T, Kuang S, Dong Y, Vidal-Puig A, Zhang Y, Jia Z
Nature communications 2026 Feb 2;17(1)
Nature communications 2026 Feb 2;17(1)
Annexin A1 exacerbates islet stellate cell activation by regulating triglyceride catabolism via the PPARα/ACOX1/CYP4a pathway.
Li Q, Zhang Y, Yu T, Shi L, Qiu Q, Wang B, Sang Y, Li R, Lv Q, Wang J, Liu X, Geng H, Jones PM, Liang J, Xu W
Islets 2026 Dec 31;18(1):2633793
Islets 2026 Dec 31;18(1):2633793
African swine fever virus hijacks lipolysis induced by chaperone-mediated autophagy to upregulate fatty acid β-oxidation and promote viral replication.
Yang X, Xiong X, Liu H, Wen X, Shi X, Ma H, Wang R, Cao W, Yang F, Ru Y, Tian H, He J, Guo J, Han S, Zhu Z, Zheng H
mBio 2026 Apr 8;17(4):e0336825
mBio 2026 Apr 8;17(4):e0336825
A new investigation of nonalcoholic fatty liver disease: Effects of hypoxia on mitochondrial function and lipid droplet autophagy.
Tian M, Zhang Y, Liu Z, Zhao N, Huang D, Hou J, Sun L, Jiang Y, Zhang G, Ma Y
PloS one 2025;20(9):e0331305
PloS one 2025;20(9):e0331305
PEDF Overexpression Ameliorates Cardiac Lipotoxicity in Diabetic Cardiomyopathy via Regulation of Energy Metabolism.
Mao T, Wang Y
Diabetes, metabolic syndrome and obesity : targets and therapy 2025;18:217-231
Diabetes, metabolic syndrome and obesity : targets and therapy 2025;18:217-231
Identification of Biomarkers for Sepsis-Induced Acute Lung Injury Through Bioinformatics and Machine Learning Approaches, with Experimental Validation.
Luo Y, Xu J, He N, Cao W
Journal of inflammation research 2025;18:13635-13650
Journal of inflammation research 2025;18:13635-13650
Circadian control of hepatic ischemia/reperfusion injury via HSD17B13-mediated autophagy in hepatocytes.
Wang H, Guo M, Ren B, Zhang H, Zhang J, Qiao R, Qian L, Zhu J, Zhang S, Su W, Zhang X, Yang G, Guan Y, Chen L
Journal of hepatology 2025 Sep;83(3):750-767
Journal of hepatology 2025 Sep;83(3):750-767
Vimentin intermediate filaments orchestrate DNA nonhomologous end joining repair and lipolysis after DNA damage.
Wang F, Rong M, Zhang L, Solomon AD, Gui W, Li J, Wang R, Wu J, Wang L, Yang X, Peng A
Oncogene 2025 Sep;44(33):3025-3036
Oncogene 2025 Sep;44(33):3025-3036
NAT10-mediated N4-acetylcytidine modification in KLF9 mRNA promotes adipogenesis.
Wan X, Wang L, Khan MA, Peng L, Sun X, Yi X, Wang Z, Chen K
Cell death and differentiation 2025 Sep;32(9):1613-1629
Cell death and differentiation 2025 Sep;32(9):1613-1629
Mechanisms of metabolic-associated fatty liver disease induced by 48-week PCB138 exposure and theabrownin intervention.
Han J, Liu C, Chen Z, Ruan F, Xue F, Ye L, Yu Y, Zuo Z, He C
Environment international 2025 Sep;203:109780
Environment international 2025 Sep;203:109780
Jiangtang Tiaozhi formula ameliorates MASLD by regulating liver ABCD2/PEX2/ATGL axis-mediated fatty acid metabolic reprogramming.
Miao R, Zhang Y, Zhang Y, Fang X, Yin R, Tian J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:157032
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:157032
Betaine decreases hepatic lipid deposition through DNA 5 mC and RNA m(6)A methylation-mediated regulation of fatty acid metabolic genes expression in laying hens.
Yang Y, Jin X, Lu D, Wu Y, Meng F, Zhang M, Wang J, Cui X, Li T, Wang S, Luo X, Hu Y
Poultry science 2025 Sep;104(9):105496
Poultry science 2025 Sep;104(9):105496
AAV9-mediated gene supplementation therapy prevents and rescues arrhythmogenic cardiomyopathy in Pnpla2-mutated mice.
Zhang X, Wang C, Chang Y, Jia H, Zhang Y, Wang Y, Wang W, Han H, Hu Y, Shao X, Wen S, Tan S, Zhang N, Hua X, Cui H, Chen X, Song J
Molecular therapy : the journal of the American Society of Gene Therapy 2025 Sep 3;33(9):4259-4275
Molecular therapy : the journal of the American Society of Gene Therapy 2025 Sep 3;33(9):4259-4275
Proinflammatory polarization of adipose tissue macrophages in cows with subclinical ketosis constitutes a critical driver of adipose tissue remodeling and inflammation.
Zhao B, Li M, Zhang H, Chang R, Wang J, Zhao W, Yang Y, Usman M, Loor JJ, Xu C
Journal of animal science and biotechnology 2025 Sep 29;16(1):130
Journal of animal science and biotechnology 2025 Sep 29;16(1):130
A two-strata energy flux system driven by a stress hormone prioritizes cardiac energetics.
Rao Z, Chen Z, Bao Y, Lu Z, Tang Y, Zhu J, Ma J, Dong S, Shi J, Sheng S, Chen Y, Wang J, Mukondiwa AV, Li Z, Wang X, Huang Z, Li C, Ding W, Chen M, Han Z, Wang C, Pan X, Wang X, Zhu H, Lin L, Huang Z, Lu W, Li X, Luo Y
Signal transduction and targeted therapy 2025 Sep 26;10(1):315
Signal transduction and targeted therapy 2025 Sep 26;10(1):315
Chronic Waterborne Exposure to Polystyrene Microplastics Induces Kupffer Cell Polarization Imbalance and Hepatic Lipid Accumulation.
Li T, Yao Z, Huang Y, Li R, Zhang L, Chen R, Gu W
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Sep 15;39(17):e70980
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Sep 15;39(17):e70980
A galacturonan from sea buckthorn (Hippophae rhamnoides L.) berry modulates dyslipidemia by promoting hepatic lipolysis and mitochondrial oxidation.
Sun Y, Ni W, Wang D, Ren J, Zhao D, Yu S, Liu S, Zhang S, Wang S, Wang W, Liu M
Carbohydrate polymers 2025 Sep 1;363:123708
Carbohydrate polymers 2025 Sep 1;363:123708
Glia maturation factor-β deficiency improves insulin resistance by promoting CARM1-mediated lipid turnover.
Xu J, Zhu L, Li J, Xu J, Cui T, Jia S, Zhu T, Shi S, Gao F, Jin C, Tian H, Wang J, Ou Q, Xu JY, Bi YL, Xu GT, Zhang X, Lu L
Pharmacological research 2025 Oct;220:107937
Pharmacological research 2025 Oct;220:107937
TRIM59 deficiency aggravates HFD-induced obesity in mice associated with increased adipose tissue inflammation, lipid accumulation, and apoptosis.
Chen Y, Han X, Liu T, Ni Y, Deng X, Wei W, Jiang M
Cellular signalling 2025 Oct;134:111954
Cellular signalling 2025 Oct;134:111954
Cetacean loss of the master adipose tissue regulator β(3)-adrenergic receptor may underlie their thick blubber and an Oligocene radiation and dispersal.
Tian R, Zhang T, Dong H, Seim I, Yang G
Nature communications 2025 Oct 17;16(1):9235
Nature communications 2025 Oct 17;16(1):9235
Cetacean-specific GPR12 mutation is functionally associated with blubber thickening.
Wang Y, Zhang Q, Xu G, Zhang H, Liu X, Yang G
Gene 2025 Oct 10;968:149734
Gene 2025 Oct 10;968:149734
1-Linoleoylglycerophosphocholine stimulates UCP1-dependent thermogenesis and mitochondrial respiration to combat obesity.
Wang R, Zhu T, Lu J, Cheng M, Wang X, Guo X, Huang S, Gao J
Journal of lipid research 2025 Nov;66(11):100914
Journal of lipid research 2025 Nov;66(11):100914
The cyclic peptide mallotumide A inhibits colon and breast cancer cell growth and motility by targeting cellular respiration and lipogenesis.
Laowittawat C, Sawektreeratana N, Katewongsa K, Payomhom P, Hongthong S, Reutrakul V, Kuhakarn C, Jitrapakdee S
Scientific reports 2025 Nov 19;15(1):40774
Scientific reports 2025 Nov 19;15(1):40774
RAB18 deficiency disrupts lipid metabolism and autophagy in mice.
Zhang LW, Han YQ, Yang Y, Li YJ, Ma YX, Ming SL
Biochemical and biophysical research communications 2025 May 26;760:151673
Biochemical and biophysical research communications 2025 May 26;760:151673
Arctiin, a lignan compound, enhances adipose tissue browning and energy expenditure by activating the adenosine A(2A) receptor.
Gu Y, He W, Li W, Cai J, Wang Z, Li K, Qin G, Gu X, Lin X, Ma L, Xiao X, Hou Y, Luo T
Molecular medicine (Cambridge, Mass.) 2025 May 14;31(1):188
Molecular medicine (Cambridge, Mass.) 2025 May 14;31(1):188
Study on metabolic disorders in rat liver induced by different times after scalds.
Chen Z, Lin H, Su X, Xu W, Fang W, Ruan G, Wang Z, Xu G, Pang R
Biochemistry and biophysics reports 2025 Mar;41:101904
Biochemistry and biophysics reports 2025 Mar;41:101904
Oral exposure to nanoplastics altered lipid profiles in mouse intestine.
Luo S, Zhao X, Wang Y, Jiang M, Cao Y
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Mar;197:115304
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Mar;197:115304
Dicyclohexyl phthalate derails trophoblast function and lipid metabolism through NDRG1 by targeting PPARα:RXRα.
Zhang Y, Geng Y, Zhang Y, Ma Y, Yin X, Chen Z, Mu X, Gao R, Chen X, Li F, He J
Toxicology 2025 Jun;514:154124
Toxicology 2025 Jun;514:154124
PRRSV Nsp4 induces ATGL protein degradation to promote viral replication and lipid droplet accumulation.
Xie E, Wang Q, Yi H, Wang J, Liu X, Ye R, Lu L, Tian T, Chen A, Zheng G, Zhang G, Wang H
International journal of biological macromolecules 2025 Jun;312:144097
International journal of biological macromolecules 2025 Jun;312:144097
Human transmembrane protein 68 links triacylglycerol synthesis to membrane lipid homeostasis.
Zeng F, Heier C, Yu Q, Pang H, Huang F, Zhao Z, Chang P
The FEBS journal 2025 Jun;292(11):2935-2952
The FEBS journal 2025 Jun;292(11):2935-2952
Rapamycin induced autophagy enhances lipid breakdown and ameliorates lipotoxicity in Atlantic salmon cells.
Phadwal K, Haggarty J, Kurian D, Martí JA, Sun J, Houston RD, Betancor MB, MacRae VE, Whitfield PD, Macqueen DJ
Biochimica et biophysica acta. Molecular and cell biology of lipids 2025 Jun;1870(5):159636
Biochimica et biophysica acta. Molecular and cell biology of lipids 2025 Jun;1870(5):159636
The lysosomal membrane protein LAMP2B mediates microlipophagy to target obesity-related disorders.
Sakai R, Aizawa S, Lee-Okada HC, Hase K, Fujita H, Kikuchi H, Inoue YU, Inoue T, Kabuta C, Yokomizo T, Hashimoto T, Wada K, Mano T, Koyama-Honda I, Kabuta T
Cell reports 2025 Jun 24;44(6):115829
Cell reports 2025 Jun 24;44(6):115829
Clinicopathological-genetic features of neutral lipid storage disease with myopathy from a Chinese neuromuscular center.
Luan YN, Shi GZ, Li QX, Huang K, Yang H
Orphanet journal of rare diseases 2025 Jul 1;20(1):322
Orphanet journal of rare diseases 2025 Jul 1;20(1):322
cTAGE5 is essential for adipogenesis and adipose tissue development.
Fan J, Ma T, Ren X, Chang Z, Zhang D, Wang Y, Cheng S, Qi X, Liu K, Wang Y, Wang Y, Xu Z, He W
Nature communications 2025 Jul 1;16(1):5457
Nature communications 2025 Jul 1;16(1):5457
Polystyrene nanoplastics promote colitis-associated cancer by disrupting lipid metabolism and inducing DNA damage.
Tian S, Li R, Li J, Zou J
Environment international 2025 Jan;195:109258
Environment international 2025 Jan;195:109258
Effects of duration of high-fat diet on adipocyte hyperplasia in rat epididymis.
Wang Z, Liu X, Sheng L, Xie Y, Feng W, Yu L
Obesity research & clinical practice 2025 Jan-Feb;19(1):54-62
Obesity research & clinical practice 2025 Jan-Feb;19(1):54-62
Intermittent fasting triggers interorgan communication to suppress hair follicle regeneration.
Chen H, Liu C, Cui S, Xia Y, Zhang K, Cheng H, Peng J, Yu X, Li L, Yu H, Zhang J, Zheng JS, Zhang B
Cell 2025 Jan 9;188(1):157-174.e22
Cell 2025 Jan 9;188(1):157-174.e22
The cholesterol metabolite 25-hydroxycholesterol suppresses porcine deltacoronavirus via lipophagy inhibition and mTORC1 modulation.
Zhang JL, Wang XF, Li JL, Duan C, Wang JF
Veterinary research 2025 Jan 31;56(1):23
Veterinary research 2025 Jan 31;56(1):23
SIRT6 Ameliorates Cancer Cachexia-Associated Adipose Wasting by Suppressing TNFR2 Signalling in Mice.
Xu K, Wang Y, Wang F, Guo Y, Ren Y, Low V, Cho S, Liu Q, Qiu Y, Li X, Yu K, Li Z, Wang Z
Journal of cachexia, sarcopenia and muscle 2025 Feb;16(1):e13734
Journal of cachexia, sarcopenia and muscle 2025 Feb;16(1):e13734
Trans 10, cis 12-conjugated linoleic acid in low concentration reduces while in high concentration enhances adipocyte metabolism but effectively improves hepatic steatosis of obese mice.
Rao Y, Yu S, Liang L, Wang Q, Lu J, Wang B, Gou K
The Journal of nutritional biochemistry 2025 Feb;136:109801
The Journal of nutritional biochemistry 2025 Feb;136:109801
Liver ALKBH5 regulates glucose and lipid homeostasis independently through GCGR and mTORC1 signaling.
Ding K, Zhang Z, Han Z, Shi L, Li X, Liu Y, Li Z, Zhao C, Cui Y, Zhou L, Xu B, Zhou W, Zhao Y, Wang Z, Huang H, Xie L, Chen XW, Chen Z
Science (New York, N.Y.) 2025 Feb 28;387(6737):eadp4120
Science (New York, N.Y.) 2025 Feb 28;387(6737):eadp4120
Isoliquiritigenin Ameliorates High-Fat Diet-Induced Obesity in Mice by Activating Brown Adipose Tissue.
Zhao L, Li M, Zhu Q, Fang X, Yang H, Zhao Y
International journal of molecular sciences 2025 Feb 14;26(4)
International journal of molecular sciences 2025 Feb 14;26(4)
Vitisin A Outperforms Cyanidin-3-O-Glucoside in Triglyceride Reduction by Modulating Hepatic Lipogenesis and Fatty Acid β-Oxidation.
Li Y, Li X, Liu J, Jayavanth P, Bai W, Jiao R
International journal of molecular sciences 2025 Feb 11;26(4)
International journal of molecular sciences 2025 Feb 11;26(4)
Mdivi-1 promotes lipid droplets-mitochondria contact and ameliorates cardiac lipotoxicity in high-fat diet-fed mice.
Xu Z, Ma Z, Ren H, Yang Y, Zhao X, Zhang B
Pharmacological research 2025 Dec;222:108028
Pharmacological research 2025 Dec;222:108028
NG-497 Alleviates Microglia-Mediated Neuroinflammation in a MTNR1A-Dependent Manner.
Li Q, Liu P, Zhu X, Zhou C, Hu Y, Cao S, Li H, Zou X, Gao S, Cao X, Bao X, Xu Y, Li J
Inflammation 2025 Aug;48(4):2663-2676
Inflammation 2025 Aug;48(4):2663-2676
RGFP966 inhibits palmitic acid induced VSMCs phenotypic transition by targeting ATGL.
Zhang S, Nie F, Zeng Y, Yang Z, Song W, Yan X, Tang Z, Fu Y, Guo R
Biochimica et biophysica acta. Molecular and cell biology of lipids 2025 Apr;1870(3):159597
Biochimica et biophysica acta. Molecular and cell biology of lipids 2025 Apr;1870(3):159597
Loss of lipid droplet-mitochondria contacts confers protection against ethanol-induced cardiotoxicity.
He W, He W, Zeng L, Zhao R, Qiu K, He P, Sun Z, Tan N
Experimental cell research 2025 Apr 15;447(2):114517
Experimental cell research 2025 Apr 15;447(2):114517
Bushen Huoxue formula attenuates lipid accumulation evoking excessive autophagy in premature ovarian insufficiency rats and palmitic acid-challenged KGN cells by modulating lipid metabolism.
Li T, Wei Y, Jiao B, Hao R, Zhou B, Bian X, Wang P, Zhou Y, Sun X, Zhang J
Frontiers in pharmacology 2024;15:1425844
Frontiers in pharmacology 2024;15:1425844
Lipolysis engages CD36 to promote ZBP1-mediated necroptosis-impairing lung regeneration in COPD.
Wang J, Wang R, Li Y, Huang J, Liu Y, Wang J, Xian P, Zhang Y, Yang Y, Zhang H, Li J
Cell reports. Medicine 2024 Sep 17;5(9):101732
Cell reports. Medicine 2024 Sep 17;5(9):101732
Dahuang Huanglian Xiexin Decoction ameliorates obesity via modulating adipocyte differentiation and lipid degradation through inhibiting endoplasmic reticulum stress.
Hao L, Li M, Gu H, Li J
Prostaglandins & other lipid mediators 2024 Oct;174:106874
Prostaglandins & other lipid mediators 2024 Oct;174:106874
Pea Albumin Alleviates Oleic Acid-Induced Lipid Accumulation in LO2 Cells Through Modulating Lipid Metabolism and Fatty Acid Oxidation Pathways.
Fang B, Luo J, Cui Z, Liu R, Wang P, Zhang J
Foods (Basel, Switzerland) 2024 Oct 30;13(21)
Foods (Basel, Switzerland) 2024 Oct 30;13(21)
Contribution of impaired autophagy, mitochondrial dysfunction and abnormal lipolysis to epididymal aging in mice.
Liu C, Wu C, Zhang S, Lv Z
Experimental gerontology 2024 Oct 1;195:112528
Experimental gerontology 2024 Oct 1;195:112528
Diallyl disulfide alleviates hepatic steatosis by the conservative mechanism from fish to tetrapod: Augment Mfn2/Atgl-Mediated lipid droplet-mitochondria coupling.
Wang LJ, Lai XH, Luo Z, Feng GL, Song YF
Redox biology 2024 Nov;77:103395
Redox biology 2024 Nov;77:103395
Sestrin2 in POMC neurons modulates energy balance and obesity related metabolic disorders via mTOR signaling.
Hu H, Lu X, He Y, Li J, Wang S, Luo Z, Wang Y, Wei J, Huang H, Duan C, Sun N
The Journal of nutritional biochemistry 2024 Nov;133:109703
The Journal of nutritional biochemistry 2024 Nov;133:109703
Transgenic female mice producing trans 10, cis 12-conjugated linoleic acid present excessive prostaglandin E2, adrenaline, corticosterone, glucagon, and FGF21.
Rao Y, Liang LW, Li MJ, Wang YY, Wang BZ, Gou KM
Scientific reports 2024 May 30;14(1):12430
Scientific reports 2024 May 30;14(1):12430
Activation of lipophagy ameliorates cadmium-induced neural tube defects via reducing low density lipoprotein cholesterol levels in mouse placentas.
Zhang YF, Zhang S, Ling Q, Chang W, Tan LL, Zhang J, Xiong YW, Zhu HL, Bian P, Wang H
Cell biology and toxicology 2024 May 21;40(1):35
Cell biology and toxicology 2024 May 21;40(1):35
Lipolysis inhibition improves the survival of fat grafts through ameliorating lipotoxicity and inflammation.
Niu X, Zhang Y, Lai Z, Huang X, Guo L, Lu F, Yuan Y, Gao J, Chang Q
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Mar 15;38(5):e23520
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Mar 15;38(5):e23520
Calmodulin Contributes to Lipolysis and Inflammatory Responses in Clinical Ketosis Cows through the TLR4/IKK/NF-κB Pathway.
Chang J, Wang Z, Hao Y, Song Y, Xia C
Animals : an open access journal from MDPI 2024 Jun 4;14(11)
Animals : an open access journal from MDPI 2024 Jun 4;14(11)
Roles of pigment epithelium-derived factor in exercise-induced suppression of senescence and its impact on lung pathology in mice.
Tsushima H, Tada H, Asai A, Hirose M, Hosoyama T, Watanabe A, Murakami T, Sugimoto M
Aging 2024 Jun 26;16(13):10670-10693
Aging 2024 Jun 26;16(13):10670-10693
Pea Albumin Extracted from Pea (Pisum sativum L.) Seeds Ameliorates High-Fat-Diet-Induced Non-Alcoholic Fatty Liver Disease by Regulating Lipogenesis and Lipolysis Pathways.
Zhang S, Cui Z, Zhang H, Wang P, Wang F, Zhang J
Nutrients 2024 Jul 11;16(14)
Nutrients 2024 Jul 11;16(14)
Lipodystrophic gene Agpat2 deficiency aggravates hyperlipidemia and atherosclerosis in Ldlr(-/-) mice.
Peng K, Chen X, Pei K, Wang X, Ma X, Liang C, Dong Q, Liu Z, Han M, Liu G, Yang H, Zheng M, Liu G, Gao M
Biochimica et biophysica acta. Molecular basis of disease 2024 Jan;1870(1):166850
Biochimica et biophysica acta. Molecular basis of disease 2024 Jan;1870(1):166850
Dietary manganese supplementation decreases hepatic lipid deposition by regulating gene expression and enzyme activity involved in lipid metabolism in the liver of broilers.
Yang K, Cui X, Hu Y, Feng X, Chen W, Zhang W, Zhang L, Li S, Hu Y, Li T, Wang S, Luo X
Journal of animal science 2024 Jan 3;102
Journal of animal science 2024 Jan 3;102
FXR overexpression prevents hepatic steatosis through inhibiting AIM2 inflammasome activation in alcoholic liver disease.
Li L, Kong L, Xu S, Wang C, Gu J, Luo H, Meng Q
Hepatology international 2024 Feb;18(1):188-205
Hepatology international 2024 Feb;18(1):188-205
CircITGB5 regulates the proliferation and adipogenic differentiation of chicken intramuscular preadipocytes through the miR-181b-5p/CPT1A axis.
Li H, Zhang H, Dai Y, Li S, Gu J, Wu R, Jia J, Shen J, Zhang Y, Li H, Liu X, Tian Y, Kang X, Zhao Y, Li G
International journal of biological macromolecules 2024 Dec;283(Pt 4):137608
International journal of biological macromolecules 2024 Dec;283(Pt 4):137608
Sleep deprivation induced fat accumulation in the visceral white adipose tissue by suppressing SIRT1/FOXO1/ATGL pathway activation.
Wang W, Liu K, Xu H, Zhang C, Zhang Y, Ding M, Xing C, Huang X, Wen Q, Lu C, Song L
Journal of physiology and biochemistry 2024 Aug;80(3):561-572
Journal of physiology and biochemistry 2024 Aug;80(3):561-572
Voluntary Wheel Running Reduces Cardiometabolic Risks in Female Offspring Exposed to Lifelong High-Fat, High-Sucrose Diet.
Gonzalez K, Merlin AC, Roye E, Ju B, Lee Y, Chicco AJ, Chung E
Medicine and science in sports and exercise 2024 Aug 1;56(8):1378-1389
Medicine and science in sports and exercise 2024 Aug 1;56(8):1378-1389
Hepatocyte-Specific PEX16 Abrogation in Mice Leads to Hepatocyte Proliferation, Alteration of Hepatic Lipid Metabolism, and Resistance to High-Fat Diet (HFD)-Induced Hepatic Steatosis and Obesity.
Chen X, Wang L, Denning KL, Mazur A, Xu Y, Wang K, Lawrence LM, Wang X, Lu Y
Biomedicines 2024 Apr 30;12(5)
Biomedicines 2024 Apr 30;12(5)
In Vitro Comparative Analysis of the Effect and Structure-Based Influencing Factors of Flavonols on Lipid Accumulation.
Ang B, Yang T, Wang Z, Cheng Y, Chen Q, Wang Z, Zeng M, Chen J, He Z
Journal of agricultural and food chemistry 2024 Apr 10;72(14):8237-8246
Journal of agricultural and food chemistry 2024 Apr 10;72(14):8237-8246
PM(2.5) exposure aggravates kidney damage by facilitating the lipid metabolism disorder in diabetic mice.
Jiang Y, Peng Y, Yang X, Yu J, Yu F, Yuan J, Zha Y
PeerJ 2023;11:e15856
PeerJ 2023;11:e15856
WTAP boosts lipid oxidation and induces diabetic cardiac fibrosis by enhancing AR methylation.
Song K, Sun H, Tu B, Zhou Y, Lin LC, Liu ZY, Li R, Yang JJ, Zhang Y, Zhao JY, Tao H
iScience 2023 Oct 20;26(10):107931
iScience 2023 Oct 20;26(10):107931
Miquelianin in Folium Nelumbinis extract promotes white-to-beige fat conversion via blocking AMPK/DRP1/mitophagy and modulating gut microbiota in HFD-fed mice.
Wang Z, Yang T, Zeng M, Wang Z, Chen Q, Chen J, Christian M, He Z
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Nov;181:114089
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Nov;181:114089
Ablation of pigment epithelium-derived factor receptor (PEDF-R/Pnpla2) causes photoreceptor degeneration.
Bernardo-Colón A, Dong L, Abu-Asab M, Brush RS, Agbaga MP, Becerra SP
Journal of lipid research 2023 May;64(5):100358
Journal of lipid research 2023 May;64(5):100358
Sulfur mustard analog 2-chloroethyl ethyl sulfide increases triglycerides by activating DGAT1-dependent biogenesis and inhibiting PGC1ɑ-dependent fat catabolism in immortalized human bronchial epithelial cells.
Ye F, Zeng Q, Dan G, Zhao Y, Yu W, Cheng J, Chen M, Wang B, Zhao J, Sai Y, Zou Z
Toxicology mechanisms and methods 2023 May;33(4):271-278
Toxicology mechanisms and methods 2023 May;33(4):271-278
Lycopene inhibits endothelial-to-mesenchymal transition of choroidal vascular endothelial cells in laser-induced mouse choroidal neovascularization.
Li L, Cao X, Huang L, Huang X, Gu J, Yu X, Zhu Y, Zhou Y, Song Y, Zhu M
Journal of cellular and molecular medicine 2023 May;27(10):1327-1340
Journal of cellular and molecular medicine 2023 May;27(10):1327-1340
5-HEPE reduces obesity and insulin resistance by promoting adipose tissue browning through GPR119/AMPK/PGC1α activation.
Zong Y, Wang M, Liu Y, Suo X, Fan G, Yang X
Life sciences 2023 Jun 15;323:121703
Life sciences 2023 Jun 15;323:121703
Mitigation of non-alcoholic steatohepatitis via recombinant Orosomucoid 2, an acute phase protein modulating the Erk1/2-PPARγ-Cd36 pathway.
Li L, Sun H, Chen J, Ding C, Yang X, Han H, Sun Q
Cell reports 2023 Jul 25;42(7):112697
Cell reports 2023 Jul 25;42(7):112697
Activation of Atg5-dependent placental lipophagy ameliorates cadmium-induced fetal growth restriction.
Zhang YF, Zhu HL, Xu XF, Zhang J, Ling Q, Zhang S, Chang W, Xiong YW, Xu DX, Wang H
Environmental pollution (Barking, Essex : 1987) 2023 Jul 1;328:121602
Environmental pollution (Barking, Essex : 1987) 2023 Jul 1;328:121602
TRIM21 attenuates renal carcinoma lipogenesis and malignancy by regulating SREBF1 protein stability.
Chen X, Yong H, Chen M, Deng C, Wang P, Chu S, Li M, Hou P, Zheng J, Li Z, Bai J
Journal of experimental & clinical cancer research : CR 2023 Jan 25;42(1):34
Journal of experimental & clinical cancer research : CR 2023 Jan 25;42(1):34
Knockout of ICAT in Adipose Tissue Alleviates Fibro-inflammation in Obese Mice.
Song Z, Liu N, He Y, Chen J, Li J, Wang F, Wu Z
Inflammation 2023 Feb;46(1):404-417
Inflammation 2023 Feb;46(1):404-417
Tumor-secreted GRP78 induces M2 polarization of macrophages by promoting lipid catabolism.
Tian J, Zhang L, La X, Fan X, Li A, Wu C, An Y, Yan S, Dong X, Wu H, Li Z
Cellular signalling 2023 Aug;108:110719
Cellular signalling 2023 Aug;108:110719
CircRNA-mediated regulation of brown adipose tissue adipogenesis.
Liu K, Liu X, Deng Y, Li Z, Tang A
Frontiers in nutrition 2022;9:926024
Frontiers in nutrition 2022;9:926024
Graphene oxide links alterations of anti-viral signaling pathways with lipid metabolism via suppressing TLR3 in vascular smooth muscle cells.
Luo Y, Li J, Huang C, Wang X, Long D, Cao Y
Molecular omics 2022 Sep 26;18(8):779-790
Molecular omics 2022 Sep 26;18(8):779-790
Human gingival mesenchymal stem cells improve movement disorders and tyrosine hydroxylase neuronal damage in Parkinson disease rats.
Lei T, Xiao Z, Zhang X, Cai S, Bi W, Yang Y, Wang D, Li Q, Du H
Cytotherapy 2022 Nov;24(11):1105-1120
Cytotherapy 2022 Nov;24(11):1105-1120
Pu-erh tea increases the metabolite Cinnabarinic acid to improve circadian rhythm disorder-induced obesity.
Hu S, Hu C, Luo L, Zhang H, Zhao S, Liu Z, Zeng L
Food chemistry 2022 Nov 15;394:133500
Food chemistry 2022 Nov 15;394:133500
Aerobic exercise promotes the expression of ATGL and attenuates inflammation to improve hepatic steatosis via lncRNA SRA.
Wu B, Xu C, Tian Y, Zeng Y, Yan F, Chen A, Zhao J, Chen L
Scientific reports 2022 Mar 30;12(1):5370
Scientific reports 2022 Mar 30;12(1):5370
Baicalin ameliorates alcohol-induced hepatic steatosis by suppressing SREBP1c elicited PNPLA3 competitive binding to ATGL.
Li P, Chen Y, Ke X, Zhang R, Zuo L, Wang M, Chen Z, Luo X, Wang J
Archives of biochemistry and biophysics 2022 Jun 15;722:109236
Archives of biochemistry and biophysics 2022 Jun 15;722:109236
Endurance exercise-mediated metabolic reshuffle attenuates high-caloric diet-induced non-alcoholic fatty liver disease.
Cook JJ, Wei M, Segovia B, Cosio-Lima L, Simpson J, Taylor S, Koh Y, Kim S, Lee Y
Annals of hepatology 2022 Jul-Aug;27(4):100709
Annals of hepatology 2022 Jul-Aug;27(4):100709
Phenotypic and genotypic changes in obesity and type 2 diabetes of male KK mice with aging.
Iizuka Y, Kim H, Nakasatomi M, Matsumoto A, Shimizu J
Experimental animals 2022 Feb 9;71(1):71-81
Experimental animals 2022 Feb 9;71(1):71-81
Ginsenoside CK ameliorates hepatic lipid accumulation via activating the LKB1/AMPK pathway in vitro and in vivo.
Zhang J, Ma X, Fan D
Food & function 2022 Feb 7;13(3):1153-1167
Food & function 2022 Feb 7;13(3):1153-1167
FUS Mutation Causes Disordered Lipid Metabolism in Skeletal Muscle Associated with ALS.
Zhou B, Zheng Y, Li X, Dong H, Yu J, Zou Y, Zhu M, Yu Y, Fang X, Zhou M, Zhang W, Yuan Y, Wang Z, Deng J, Hong D
Molecular neurobiology 2022 Dec;59(12):7265-7277
Molecular neurobiology 2022 Dec;59(12):7265-7277
Polyphyllin I improves myocardial damage in coronary artery disease via modulating lipid metabolism and myocardial apoptosis.
Yang Z, Yang X, An M
Journal of biochemical and molecular toxicology 2022 Dec;36(12):e23219
Journal of biochemical and molecular toxicology 2022 Dec;36(12):e23219
Microalgae oil from Schizochytrium sp. alleviates obesity and modulates gut microbiota in high-fat diet-fed mice.
Ran L, Yu J, Ma R, Yao Q, Wang M, Bi Y, Yu Z, Wu Y
Food & function 2022 Dec 13;13(24):12799-12813
Food & function 2022 Dec 13;13(24):12799-12813
Deficiency of WTAP in hepatocytes induces lipoatrophy and non-alcoholic steatohepatitis (NASH).
Li X, Ding K, Li X, Yuan B, Wang Y, Yao Z, Wang S, Huang H, Xu B, Xie L, Deng T, Chen XW, Chen Z
Nature communications 2022 Aug 4;13(1):4549
Nature communications 2022 Aug 4;13(1):4549
Lipid metabolism is involved in the association of rotavirus viroplasms with endoplasmic reticulum membranes.
Martínez JL, Eichwald C, Schraner EM, López S, Arias CF
Virology 2022 Apr;569:29-36
Virology 2022 Apr;569:29-36
Functionalized gadofullerene ameliorates impaired glycolipid metabolism in type 2 diabetic mice.
Wu J, Chen Y, Li X, Ran L, Liu X, Wang X, Zhen M, Shao S, Zeng L, Wang C, Liang B, Zhao J, Wu Y
Journal of genetics and genomics = Yi chuan xue bao 2022 Apr;49(4):364-376
Journal of genetics and genomics = Yi chuan xue bao 2022 Apr;49(4):364-376
The vesicular transporter STX11 governs ATGL-mediated hepatic lipolysis and lipophagy.
Zhang G, Han J, Wang L, Yang X, Yan Z, Qu M, Zhou H, Bilal H, Wang F, Ge H, Yang X
iScience 2022 Apr 15;25(4):104085
iScience 2022 Apr 15;25(4):104085
Quantitative proteomic analysis identified differentially expressed proteins with tail/rump fat deposition in Chinese thin- and fat-tailed lambs.
Han J, Guo T, Yue Y, Lu Z, Liu J, Yuan C, Niu C, Yang M, Yang B
PloS one 2021;16(2):e0246279
PloS one 2021;16(2):e0246279
Function of Chick Subcutaneous Adipose Tissue During the Embryonic and Posthatch Period.
Zhao H, Wu M, Tang X, Li Q, Yi X, Wang S, Jia C, Wei Z, Sun X
Frontiers in physiology 2021;12:684426
Frontiers in physiology 2021;12:684426
Sulfated glucuronomannan hexasaccharide G6S1 enhanced lipolysis and lipophagy via PPARα pathway.
Cai M, Chen Y, Wang Y, Fang Q, He X, Wu W, Bao Y, Mao G, Jin W, Zhong W
The international journal of biochemistry & cell biology 2021 Oct;139:106067
The international journal of biochemistry & cell biology 2021 Oct;139:106067
Exercise improves lipid droplet metabolism disorder through activation of AMPK-mediated lipophagy in NAFLD.
Li H, Dun Y, Zhang W, You B, Liu Y, Fu S, Qiu L, Cheng J, Ripley-Gonzalez JW, Liu S
Life sciences 2021 May 15;273:119314
Life sciences 2021 May 15;273:119314
Degradation of Photoreceptor Outer Segments by the Retinal Pigment Epithelium Requires Pigment Epithelium-Derived Factor Receptor (PEDF-R).
Bullock J, Polato F, Abu-Asab M, Bernardo-Colón A, Aflaki E, Agbaga MP, Becerra SP
Investigative ophthalmology & visual science 2021 Feb 1;62(2):30
Investigative ophthalmology & visual science 2021 Feb 1;62(2):30
Pigment epithelium-derived factor (PEDF) and derived peptides promote survival and differentiation of photoreceptors and induce neurite-outgrowth in amacrine neurons.
Michelis G, German OL, Villasmil R, Soto T, Rotstein NP, Politi L, Becerra SP
Journal of neurochemistry 2021 Dec;159(5):840-856
Journal of neurochemistry 2021 Dec;159(5):840-856
Myostatin suppresses adipogenic differentiation and lipid accumulation by activating crosstalk between ERK1/2 and PKA signaling pathways in porcine subcutaneous preadipocytes.
Pan S, Zhang L, Liu Z, Xing H
Journal of animal science 2021 Dec 1;99(12)
Journal of animal science 2021 Dec 1;99(12)
Single-cell RNA sequencing of preadipocytes reveals the cell fate heterogeneity induced by melatonin.
Li Z, Zheng M, Mo J, Li K, Yang X, Guo L, Zhang X, Abdalla BA, Nie Q
Journal of pineal research 2021 Apr;70(3):e12725
Journal of pineal research 2021 Apr;70(3):e12725
Inhibition of PAI-1 Promotes Lipolysis and Enhances Weight Loss in Obese Mice.
Levine JA, Olivares S, Miyata T, Vaughan DE, Henkel AS
Obesity (Silver Spring, Md.) 2021 Apr;29(4):713-720
Obesity (Silver Spring, Md.) 2021 Apr;29(4):713-720
CD2-Associated Protein Contributes to Hepatitis C, Virus Propagation and Steatosis by Disrupting Insulin Signaling.
Zhang H, Zhang C, Tang H, Gao S, Sun F, Yang Y, Zhou W, Hu Y, Ke C, Wu Y, Ding Z, Guo L, Pei R, Chen X, Sy MS, Zhang B, Li C
Hepatology (Baltimore, Md.) 2018 Nov;68(5):1710-1725
Hepatology (Baltimore, Md.) 2018 Nov;68(5):1710-1725
mRNA m(6)A plays opposite role in regulating UCP2 and PNPLA2 protein expression in adipocytes.
Wang X, Sun B, Jiang Q, Wu R, Cai M, Yao Y, Liu Q, Shi H, Feng J, Wang Y
International journal of obesity (2005) 2018 Nov;42(11):1912-1924
International journal of obesity (2005) 2018 Nov;42(11):1912-1924
PEDF improves cardiac function in rats subjected to myocardial ischemia/reperfusion injury by inhibiting ROS generation via PEDF‑R.
Zhao Q, Liu Z, Huang B, Yuan Y, Liu X, Zhang H, Qiu F, Zhang Y, Li Y, Miao H, Dong H, Zhang Z
International journal of molecular medicine 2018 Jun;41(6):3243-3252
International journal of molecular medicine 2018 Jun;41(6):3243-3252
miR-128-3p regulates 3T3-L1 adipogenesis and lipolysis by targeting Pparg and Sertad2.
Chen C, Deng Y, Hu X, Ren H, Zhu J, Fu S, Xie J, Peng Y
Journal of physiology and biochemistry 2018 Aug;74(3):381-393
Journal of physiology and biochemistry 2018 Aug;74(3):381-393
GLP-1/GLP-1R Signaling in Regulation of Adipocyte Differentiation and Lipogenesis.
Chen J, Zhao H, Ma X, Zhang Y, Lu S, Wang Y, Zong C, Qin D, Wang Y, Yingfeng Yang Y, Wang X, Liu Y
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;42(3):1165-1176
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;42(3):1165-1176
Loss of ABHD5 promotes the aggressiveness of prostate cancer cells.
Chen G, Zhou G, Aras S, He Z, Lucas S, Podgorski I, Skar W, Granneman JG, Wang J
Scientific reports 2017 Oct 12;7(1):13021
Scientific reports 2017 Oct 12;7(1):13021
Transcription regulator TRIP-Br2 mediates ER stress-induced brown adipocytes dysfunction.
Qiang G, Whang Kong H, Gil V, Liew CW
Scientific reports 2017 Jan 9;7:40215
Scientific reports 2017 Jan 9;7:40215
Lycium barbarum polysaccharide attenuates high-fat diet-induced hepatic steatosis by up-regulating SIRT1 expression and deacetylase activity.
Jia L, Li W, Li J, Li Y, Song H, Luan Y, Qi H, Ma L, Lu X, Yang Y
Scientific reports 2016 Nov 8;6:36209
Scientific reports 2016 Nov 8;6:36209
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The ATGL antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human ATGL. This antibody recognizes human, mouse, rat antigen. The ATGL antibody has been validated for the following applications: ELISA, WB analysis.
