55190-1-AP

antibody from Proteintech Group

Targeting: PNPLA2 ATGL, desnutrin, FP17548, iPLA2zeta, TTS-2.2

Provider product page for 55190-1-AP

Western blot

ELISA

Immunoprecipitation

Antibody data

Antibody Data
Antigen structure
References [48]
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Validations
Western blot [1]

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Product number: 55190-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#55190-1-AP, RRID:AB_11182818
Product name: ATGL antibody
Antibody type: Polyclonal
Description: KD/KO validated ATGL antibody (Cat. #55190-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

PNPLA2 protein structure - 55190-1-AP shown in red.

Submitted references Lipolysis inhibition improves the survival of fat grafts through ameliorating lipotoxicity and inflammation.

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FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Mar 15;38(5):e23520

Lipodystrophic gene Agpat2 deficiency aggravates hyperlipidemia and atherosclerosis in Ldlr(-/-) mice.

Peng K, Chen X, Pei K, Wang X, Ma X, Liang C, Dong Q, Liu Z, Han M, Liu G, Yang H, Zheng M, Liu G, Gao M
Biochimica et biophysica acta. Molecular basis of disease 2024 Jan;1870(1):166850

In Vitro Comparative Analysis of the Effect and Structure-Based Influencing Factors of Flavonols on Lipid Accumulation.

Ang B, Yang T, Wang Z, Cheng Y, Chen Q, Wang Z, Zeng M, Chen J, He Z
Journal of agricultural and food chemistry 2024 Apr 10;72(14):8237-8246

PM(2.5) exposure aggravates kidney damage by facilitating the lipid metabolism disorder in diabetic mice.

Jiang Y, Peng Y, Yang X, Yu J, Yu F, Yuan J, Zha Y
PeerJ 2023;11:e15856

WTAP boosts lipid oxidation and induces diabetic cardiac fibrosis by enhancing AR methylation.

Song K, Sun H, Tu B, Zhou Y, Lin LC, Liu ZY, Li R, Yang JJ, Zhang Y, Zhao JY, Tao H
iScience 2023 Oct 20;26(10):107931

Miquelianin in Folium Nelumbinis extract promotes white-to-beige fat conversion via blocking AMPK/DRP1/mitophagy and modulating gut microbiota in HFD-fed mice.

Wang Z, Yang T, Zeng M, Wang Z, Chen Q, Chen J, Christian M, He Z
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Nov;181:114089

Ablation of pigment epithelium-derived factor receptor (PEDF-R/Pnpla2) causes photoreceptor degeneration.

Bernardo-Colón A, Dong L, Abu-Asab M, Brush RS, Agbaga MP, Becerra SP
Journal of lipid research 2023 May;64(5):100358

Sulfur mustard analog 2-chloroethyl ethyl sulfide increases triglycerides by activating DGAT1-dependent biogenesis and inhibiting PGC1ɑ-dependent fat catabolism in immortalized human bronchial epithelial cells.

Ye F, Zeng Q, Dan G, Zhao Y, Yu W, Cheng J, Chen M, Wang B, Zhao J, Sai Y, Zou Z
Toxicology mechanisms and methods 2023 May;33(4):271-278

Lycopene inhibits endothelial-to-mesenchymal transition of choroidal vascular endothelial cells in laser-induced mouse choroidal neovascularization.

Li L, Cao X, Huang L, Huang X, Gu J, Yu X, Zhu Y, Zhou Y, Song Y, Zhu M
Journal of cellular and molecular medicine 2023 May;27(10):1327-1340

5-HEPE reduces obesity and insulin resistance by promoting adipose tissue browning through GPR119/AMPK/PGC1α activation.

Zong Y, Wang M, Liu Y, Suo X, Fan G, Yang X
Life sciences 2023 Jun 15;323:121703

Mitigation of non-alcoholic steatohepatitis via recombinant Orosomucoid 2, an acute phase protein modulating the Erk1/2-PPARγ-Cd36 pathway.

Li L, Sun H, Chen J, Ding C, Yang X, Han H, Sun Q
Cell reports 2023 Jul 25;42(7):112697

Activation of Atg5-dependent placental lipophagy ameliorates cadmium-induced fetal growth restriction.

Zhang YF, Zhu HL, Xu XF, Zhang J, Ling Q, Zhang S, Chang W, Xiong YW, Xu DX, Wang H
Environmental pollution (Barking, Essex : 1987) 2023 Jul 1;328:121602

TRIM21 attenuates renal carcinoma lipogenesis and malignancy by regulating SREBF1 protein stability.

Chen X, Yong H, Chen M, Deng C, Wang P, Chu S, Li M, Hou P, Zheng J, Li Z, Bai J
Journal of experimental & clinical cancer research : CR 2023 Jan 25;42(1):34

Knockout of ICAT in Adipose Tissue Alleviates Fibro-inflammation in Obese Mice.

Song Z, Liu N, He Y, Chen J, Li J, Wang F, Wu Z
Inflammation 2023 Feb;46(1):404-417

Tumor-secreted GRP78 induces M2 polarization of macrophages by promoting lipid catabolism.

Tian J, Zhang L, La X, Fan X, Li A, Wu C, An Y, Yan S, Dong X, Wu H, Li Z
Cellular signalling 2023 Aug;108:110719

CircRNA-mediated regulation of brown adipose tissue adipogenesis.

Liu K, Liu X, Deng Y, Li Z, Tang A
Frontiers in nutrition 2022;9:926024

Graphene oxide links alterations of anti-viral signaling pathways with lipid metabolism via suppressing TLR3 in vascular smooth muscle cells.

Luo Y, Li J, Huang C, Wang X, Long D, Cao Y
Molecular omics 2022 Sep 26;18(8):779-790

Human gingival mesenchymal stem cells improve movement disorders and tyrosine hydroxylase neuronal damage in Parkinson disease rats.

Lei T, Xiao Z, Zhang X, Cai S, Bi W, Yang Y, Wang D, Li Q, Du H
Cytotherapy 2022 Nov;24(11):1105-1120

Pu-erh tea increases the metabolite Cinnabarinic acid to improve circadian rhythm disorder-induced obesity.

Hu S, Hu C, Luo L, Zhang H, Zhao S, Liu Z, Zeng L
Food chemistry 2022 Nov 15;394:133500

Aerobic exercise promotes the expression of ATGL and attenuates inflammation to improve hepatic steatosis via lncRNA SRA.

Wu B, Xu C, Tian Y, Zeng Y, Yan F, Chen A, Zhao J, Chen L
Scientific reports 2022 Mar 30;12(1):5370

Baicalin ameliorates alcohol-induced hepatic steatosis by suppressing SREBP1c elicited PNPLA3 competitive binding to ATGL.

Li P, Chen Y, Ke X, Zhang R, Zuo L, Wang M, Chen Z, Luo X, Wang J
Archives of biochemistry and biophysics 2022 Jun 15;722:109236

Endurance exercise-mediated metabolic reshuffle attenuates high-caloric diet-induced non-alcoholic fatty liver disease.

Cook JJ, Wei M, Segovia B, Cosio-Lima L, Simpson J, Taylor S, Koh Y, Kim S, Lee Y
Annals of hepatology 2022 Jul-Aug;27(4):100709

Phenotypic and genotypic changes in obesity and type 2 diabetes of male KK mice with aging.

Iizuka Y, Kim H, Nakasatomi M, Matsumoto A, Shimizu J
Experimental animals 2022 Feb 9;71(1):71-81

Ginsenoside CK ameliorates hepatic lipid accumulation via activating the LKB1/AMPK pathway in vitro and in vivo.

Zhang J, Ma X, Fan D
Food & function 2022 Feb 7;13(3):1153-1167

FUS Mutation Causes Disordered Lipid Metabolism in Skeletal Muscle Associated with ALS.

Zhou B, Zheng Y, Li X, Dong H, Yu J, Zou Y, Zhu M, Yu Y, Fang X, Zhou M, Zhang W, Yuan Y, Wang Z, Deng J, Hong D
Molecular neurobiology 2022 Dec;59(12):7265-7277

Polyphyllin I improves myocardial damage in coronary artery disease via modulating lipid metabolism and myocardial apoptosis.

Yang Z, Yang X, An M
Journal of biochemical and molecular toxicology 2022 Dec;36(12):e23219

Microalgae oil from Schizochytrium sp. alleviates obesity and modulates gut microbiota in high-fat diet-fed mice.

Ran L, Yu J, Ma R, Yao Q, Wang M, Bi Y, Yu Z, Wu Y
Food & function 2022 Dec 13;13(24):12799-12813

Deficiency of WTAP in hepatocytes induces lipoatrophy and non-alcoholic steatohepatitis (NASH).

Li X, Ding K, Li X, Yuan B, Wang Y, Yao Z, Wang S, Huang H, Xu B, Xie L, Deng T, Chen XW, Chen Z
Nature communications 2022 Aug 4;13(1):4549

Lipid metabolism is involved in the association of rotavirus viroplasms with endoplasmic reticulum membranes.

Martínez JL, Eichwald C, Schraner EM, López S, Arias CF
Virology 2022 Apr;569:29-36

Functionalized gadofullerene ameliorates impaired glycolipid metabolism in type 2 diabetic mice.

Wu J, Chen Y, Li X, Ran L, Liu X, Wang X, Zhen M, Shao S, Zeng L, Wang C, Liang B, Zhao J, Wu Y
Journal of genetics and genomics = Yi chuan xue bao 2022 Apr;49(4):364-376

The vesicular transporter STX11 governs ATGL-mediated hepatic lipolysis and lipophagy.

Zhang G, Han J, Wang L, Yang X, Yan Z, Qu M, Zhou H, Bilal H, Wang F, Ge H, Yang X
iScience 2022 Apr 15;25(4):104085

Quantitative proteomic analysis identified differentially expressed proteins with tail/rump fat deposition in Chinese thin- and fat-tailed lambs.

Han J, Guo T, Yue Y, Lu Z, Liu J, Yuan C, Niu C, Yang M, Yang B
PloS one 2021;16(2):e0246279

Function of Chick Subcutaneous Adipose Tissue During the Embryonic and Posthatch Period.

Zhao H, Wu M, Tang X, Li Q, Yi X, Wang S, Jia C, Wei Z, Sun X
Frontiers in physiology 2021;12:684426

Sulfated glucuronomannan hexasaccharide G6S1 enhanced lipolysis and lipophagy via PPARα pathway.

Cai M, Chen Y, Wang Y, Fang Q, He X, Wu W, Bao Y, Mao G, Jin W, Zhong W
The international journal of biochemistry & cell biology 2021 Oct;139:106067

Exercise improves lipid droplet metabolism disorder through activation of AMPK-mediated lipophagy in NAFLD.

Li H, Dun Y, Zhang W, You B, Liu Y, Fu S, Qiu L, Cheng J, Ripley-Gonzalez JW, Liu S
Life sciences 2021 May 15;273:119314

Degradation of Photoreceptor Outer Segments by the Retinal Pigment Epithelium Requires Pigment Epithelium-Derived Factor Receptor (PEDF-R).

Bullock J, Polato F, Abu-Asab M, Bernardo-Colón A, Aflaki E, Agbaga MP, Becerra SP
Investigative ophthalmology & visual science 2021 Feb 1;62(2):30

Pigment epithelium-derived factor (PEDF) and derived peptides promote survival and differentiation of photoreceptors and induce neurite-outgrowth in amacrine neurons.

Michelis G, German OL, Villasmil R, Soto T, Rotstein NP, Politi L, Becerra SP
Journal of neurochemistry 2021 Dec;159(5):840-856

Myostatin suppresses adipogenic differentiation and lipid accumulation by activating crosstalk between ERK1/2 and PKA signaling pathways in porcine subcutaneous preadipocytes.

Pan S, Zhang L, Liu Z, Xing H
Journal of animal science 2021 Dec 1;99(12)

Single-cell RNA sequencing of preadipocytes reveals the cell fate heterogeneity induced by melatonin.

Li Z, Zheng M, Mo J, Li K, Yang X, Guo L, Zhang X, Abdalla BA, Nie Q
Journal of pineal research 2021 Apr;70(3):e12725

Inhibition of PAI-1 Promotes Lipolysis and Enhances Weight Loss in Obese Mice.

Levine JA, Olivares S, Miyata T, Vaughan DE, Henkel AS
Obesity (Silver Spring, Md.) 2021 Apr;29(4):713-720

CD2-Associated Protein Contributes to Hepatitis C, Virus Propagation and Steatosis by Disrupting Insulin Signaling.

Zhang H, Zhang C, Tang H, Gao S, Sun F, Yang Y, Zhou W, Hu Y, Ke C, Wu Y, Ding Z, Guo L, Pei R, Chen X, Sy MS, Zhang B, Li C
Hepatology (Baltimore, Md.) 2018 Nov;68(5):1710-1725

mRNA m(6)A plays opposite role in regulating UCP2 and PNPLA2 protein expression in adipocytes.

Wang X, Sun B, Jiang Q, Wu R, Cai M, Yao Y, Liu Q, Shi H, Feng J, Wang Y
International journal of obesity (2005) 2018 Nov;42(11):1912-1924

PEDF improves cardiac function in rats subjected to myocardial ischemia/reperfusion injury by inhibiting ROS generation via PEDF‑R.

Zhao Q, Liu Z, Huang B, Yuan Y, Liu X, Zhang H, Qiu F, Zhang Y, Li Y, Miao H, Dong H, Zhang Z
International journal of molecular medicine 2018 Jun;41(6):3243-3252

miR-128-3p regulates 3T3-L1 adipogenesis and lipolysis by targeting Pparg and Sertad2.

Chen C, Deng Y, Hu X, Ren H, Zhu J, Fu S, Xie J, Peng Y
Journal of physiology and biochemistry 2018 Aug;74(3):381-393

GLP-1/GLP-1R Signaling in Regulation of Adipocyte Differentiation and Lipogenesis.

Chen J, Zhao H, Ma X, Zhang Y, Lu S, Wang Y, Zong C, Qin D, Wang Y, Yingfeng Yang Y, Wang X, Liu Y
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;42(3):1165-1176

Loss of ABHD5 promotes the aggressiveness of prostate cancer cells.

Chen G, Zhou G, Aras S, He Z, Lucas S, Podgorski I, Skar W, Granneman JG, Wang J
Scientific reports 2017 Oct 12;7(1):13021

Transcription regulator TRIP-Br2 mediates ER stress-induced brown adipocytes dysfunction.

Qiang G, Whang Kong H, Gil V, Liew CW
Scientific reports 2017 Jan 9;7:40215

Lycium barbarum polysaccharide attenuates high-fat diet-induced hepatic steatosis by up-regulating SIRT1 expression and deacetylase activity.

Jia L, Li W, Li J, Li Y, Song H, Luan Y, Qi H, Ma L, Lu X, Yang Y
Scientific reports 2016 Nov 8;6:36209

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The ATGL antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human ATGL. This antibody recognizes human, mouse, rat antigen. The ATGL antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 55190-1-AP.pdf

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