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- Antigen structure
- References [22]
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- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 15376-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15376-1-AP, RRID:AB_2286678
- Product name
- SPTLC1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated SPTLC1 antibody (Cat. #15376-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Candidate Interaction Partners of Calpain-5 Suggest Clues to Its Involvement in Neovascular Inflammatory Vitreoretinopathy.
ER stress in D1-MSNs mediates cocaine-induced behavioral plasticity via the ATF4-SPTLC1 axis.
The Contradictory Effects of SPTLC1 on Clear Cell Renal Carcinoma Sensitivity to Sunitinib Mediated by Androgen Receptor.
PLK1-mediated phosphorylation of PHGDH reprograms serine metabolism in advanced prostate cancer.
1-Deoxysphingolipids dysregulate membrane properties and cargo trafficking in the early secretory pathway.
Integratomic investigation to assess the liver lipidomic and antiinflammatory activity of lupin protein hydrolysate.
Genome-wide identification of modulators of Chlamydia trachomatis parasitophorous vacuole stability highlights an important role for sphingolipid supply.
Glycosphingolipid synthesis mediates immune evasion in KRAS-driven cancer.
Aberrant regulation of serine metabolism drives extracellular vesicle release and cancer progression.
Inhibiting de novo ceramide synthesis restores mitochondrial and protein homeostasis in muscle aging.
A proximity labeling strategy enables proteomic analysis of inter-organelle membrane contacts.
Stearate-derived very long-chain fatty acids are indispensable to tumor growth.
Exercise training enhances muscle mitochondrial metabolism in diet-resistant obesity.
1-Deoxysphingolipid synthesis compromises anchorage-independent growth and plasma membrane endocytosis in cancer cells.
Inhibition of sphingolipid de novo synthesis counteracts muscular dystrophy.
Sphingolipids accumulate in aged muscle, and their reduction counteracts sarcopenia.
Central Ceramide Signaling Mediates Obesity-Induced Precocious Puberty.
Activation of Mitochondrial Unfolded Protein Response in SHSY5Y Expressing APP Cells and APP/PS1 Mice.
Knockout of neutrophil elastase protects against western diet induced nonalcoholic steatohepatitis in mice by regulating hepatic ceramides metabolism.
Neutrophil elastase increases airway ceramide levels via upregulation of serine palmitoyltransferase.
Inhibition of serine palmitoyltransferase reduces Aβ and tau hyperphosphorylation in a murine model: a safe therapeutic strategy for Alzheimer's disease.
MicroRNA-137/181c regulates serine palmitoyltransferase and in turn amyloid β, novel targets in sporadic Alzheimer's disease.
Gal J, Bondada V, Crasta R, Croall DE, Vary CP, Geddes JW
Cells 2026 Jan 13;15(2)
Cells 2026 Jan 13;15(2)
ER stress in D1-MSNs mediates cocaine-induced behavioral plasticity via the ATF4-SPTLC1 axis.
Zhao Y, Li S, Jiang L, Zhao Y, Kuang W, Wei Q, Zhou Y, Han S, Wang L, Li H, Dai Y, Yang X, Xu S, Qin F, Chen R, Chen Y, Liu C, Bu Q, Chen B, Liu B, Qin M, Zhao Y, Cen X
Frontiers in pharmacology 2025;16:1677343
Frontiers in pharmacology 2025;16:1677343
The Contradictory Effects of SPTLC1 on Clear Cell Renal Carcinoma Sensitivity to Sunitinib Mediated by Androgen Receptor.
Liao L, Zhang Z, Li Z, Wei D, Xie Y, Zeng H, Zhao H, Zhou Y, Gu D, Duan X
Molecular carcinogenesis 2025 Oct;64(10):1778-1791
Molecular carcinogenesis 2025 Oct;64(10):1778-1791
PLK1-mediated phosphorylation of PHGDH reprograms serine metabolism in advanced prostate cancer.
Rao X, Allison DB, Flight RM, Lin P, He D, Li Z, Zhang Y, Wang R, Li C, Wang J, Wang X, Peng J, Fong KW, Shao Q, Wang C, Ali ES, Moseley HN, Liu X
bioRxiv : the preprint server for biology 2025 May 24;
bioRxiv : the preprint server for biology 2025 May 24;
1-Deoxysphingolipids dysregulate membrane properties and cargo trafficking in the early secretory pathway.
Tsai YT, Lipp NF, Seidel O, Varma R, Laguerre A, Solorio-Kirpichyan K, Wong A, Brea RJ, McGregor GH, Cordes T, Devaraj NK, Kuerschner L, Neal S, Metallo CM, Budin I
bioRxiv : the preprint server for biology 2025 May 17;
bioRxiv : the preprint server for biology 2025 May 17;
Integratomic investigation to assess the liver lipidomic and antiinflammatory activity of lupin protein hydrolysate.
Casati S, Dei Cas M, d'Adduzio L, Cruz-Chamorro I, Santos-Sánchez G, Bollati C, Fanzaga M, Pedroche J, Millán-Linares MDC, Roda G, Carrillo-Vico A, Lammi C
NPJ science of food 2025 Jul 28;9(1):154
NPJ science of food 2025 Jul 28;9(1):154
Genome-wide identification of modulators of Chlamydia trachomatis parasitophorous vacuole stability highlights an important role for sphingolipid supply.
Babu Sait MR, Jachmann LH, Türköz G, Milivojevic M, Llorente-Sáez C, Dhanjal S, Schumacher F, Henriksson S, Gayathri Vegesna NV, Seddik N, Chaban A, Mohanty P, Ölander M, Muraleedharan S, Farmand Azadeh S, Kleuser B, Schmierer B, Sixt BS
PLoS biology 2025 Aug;23(8):e3003297
PLoS biology 2025 Aug;23(8):e3003297
Glycosphingolipid synthesis mediates immune evasion in KRAS-driven cancer.
Soula M, Unlu G, Welch R, Chudnovskiy A, Uygur B, Shah V, Alwaseem H, Bunk P, Subramanyam V, Yeh HW, Khan A, Heissel S, Goodarzi H, Victora GD, Beyaz S, Birsoy K
Nature 2024 Sep;633(8029):451-458
Nature 2024 Sep;633(8029):451-458
Aberrant regulation of serine metabolism drives extracellular vesicle release and cancer progression.
Yamamoto T, Nakayama J, Urabe F, Ito K, Nishida-Aoki N, Kitagawa M, Yokoi A, Kuroda M, Hattori Y, Yamamoto Y, Ochiya T
Cell reports 2024 Aug 27;43(8):114517
Cell reports 2024 Aug 27;43(8):114517
Inhibiting de novo ceramide synthesis restores mitochondrial and protein homeostasis in muscle aging.
Lima TI, Laurila PP, Wohlwend M, Morel JD, Goeminne LJE, Li H, Romani M, Li X, Oh CM, Park D, Rodríguez-López S, Ivanisevic J, Gallart-Ayala H, Crisol B, Delort F, Batonnet-Pichon S, Silveira LR, Sankabattula Pavani Veera Venkata L, Padala AK, Jain S, Auwerx J
Science translational medicine 2023 May 17;15(696):eade6509
Science translational medicine 2023 May 17;15(696):eade6509
A proximity labeling strategy enables proteomic analysis of inter-organelle membrane contacts.
Zhou M, Kong B, Zhang X, Xiao K, Lu J, Li W, Li M, Li Z, Ji W, Hou J, Xu T
iScience 2023 Jul 21;26(7):107159
iScience 2023 Jul 21;26(7):107159
Stearate-derived very long-chain fatty acids are indispensable to tumor growth.
Chu Q, Liu P, Song Y, Yang R, An J, Zhai X, Niu J, Yang C, Li B
The EMBO journal 2023 Jan 16;42(2):e111268
The EMBO journal 2023 Jan 16;42(2):e111268
Exercise training enhances muscle mitochondrial metabolism in diet-resistant obesity.
Pileggi CA, Blondin DP, Hooks BG, Parmar G, Alecu I, Patten DA, Cuillerier A, O'Dwyer C, Thrush AB, Fullerton MD, Bennett SA, Doucet É, Haman F, Cuperlovic-Culf M, McPherson R, Dent RRM, Harper ME
EBioMedicine 2022 Sep;83:104192
EBioMedicine 2022 Sep;83:104192
1-Deoxysphingolipid synthesis compromises anchorage-independent growth and plasma membrane endocytosis in cancer cells.
Cordes T, Kuna RS, McGregor GH, Khare SV, Gengatharan J, Muthusamy T, Metallo CM
Journal of lipid research 2022 Oct;63(10):100281
Journal of lipid research 2022 Oct;63(10):100281
Inhibition of sphingolipid de novo synthesis counteracts muscular dystrophy.
Laurila PP, Luan P, Wohlwend M, Zanou N, Crisol B, Imamura de Lima T, Goeminne LJE, Gallart-Ayala H, Shong M, Ivanisevic J, Place N, Auwerx J
Science advances 2022 Jan 28;8(4):eabh4423
Science advances 2022 Jan 28;8(4):eabh4423
Sphingolipids accumulate in aged muscle, and their reduction counteracts sarcopenia.
Laurila PP, Wohlwend M, Imamura de Lima T, Luan P, Herzig S, Zanou N, Crisol B, Bou-Sleiman M, Porcu E, Gallart-Ayala H, Handzlik MK, Wang Q, Jain S, D'Amico D, Salonen M, Metallo CM, Kutalik Z, Eichmann TO, Place N, Ivanisevic J, Lahti J, Eriksson JG, Auwerx J
Nature aging 2022 Dec;2(12):1159-1175
Nature aging 2022 Dec;2(12):1159-1175
Central Ceramide Signaling Mediates Obesity-Induced Precocious Puberty.
Heras V, Castellano JM, Fernandois D, Velasco I, Rodríguez-Vazquez E, Roa J, Vazquez MJ, Ruiz-Pino F, Rubio M, Pineda R, Torres E, Avendaño MS, Paredes A, Pinilla L, Belsham D, Diéguez C, Gaytán F, Casals N, López M, Tena-Sempere M
Cell metabolism 2020 Dec 1;32(6):951-966.e8
Cell metabolism 2020 Dec 1;32(6):951-966.e8
Activation of Mitochondrial Unfolded Protein Response in SHSY5Y Expressing APP Cells and APP/PS1 Mice.
Shen Y, Ding M, Xie Z, Liu X, Yang H, Jin S, Xu S, Zhu Z, Wang Y, Wang D, Xu L, Zhou X, Wang P, Bi J
Frontiers in cellular neuroscience 2019;13:568
Frontiers in cellular neuroscience 2019;13:568
Knockout of neutrophil elastase protects against western diet induced nonalcoholic steatohepatitis in mice by regulating hepatic ceramides metabolism.
Chen J, Liang B, Bian D, Luo Y, Yang J, Li Z, Zhuang Z, Zang S, Shi J
Biochemical and biophysical research communications 2019 Oct 22;518(4):691-697
Biochemical and biophysical research communications 2019 Oct 22;518(4):691-697
Neutrophil elastase increases airway ceramide levels via upregulation of serine palmitoyltransferase.
Karandashova S, Kummarapurugu AB, Zheng S, Chalfant CE, Voynow JA
American journal of physiology. Lung cellular and molecular physiology 2018 Jan 1;314(1):L206-L214
American journal of physiology. Lung cellular and molecular physiology 2018 Jan 1;314(1):L206-L214
Inhibition of serine palmitoyltransferase reduces Aβ and tau hyperphosphorylation in a murine model: a safe therapeutic strategy for Alzheimer's disease.
Geekiyanage H, Upadhye A, Chan C
Neurobiology of aging 2013 Aug;34(8):2037-51
Neurobiology of aging 2013 Aug;34(8):2037-51
MicroRNA-137/181c regulates serine palmitoyltransferase and in turn amyloid β, novel targets in sporadic Alzheimer's disease.
Geekiyanage H, Chan C
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Oct 12;31(41):14820-30
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Oct 12;31(41):14820-30
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Jurkat cells were subjected to SDS PAGE followed by western blot with 15376-1-AP(SPTLC1 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human colon cancer using 15376-1-AP(SPTLC1 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SPTLC1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SPTLC1. This antibody recognizes human, mouse, rat antigen. The SPTLC1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
