ABIN357775

antibody from antibodies-online

Targeting: SPTLC1 hLCB1, HSAN1, HSN1, LCB1, SPTI

Western blot (Recommended by provider)

Antibody Data

Product number

ABIN357775

Provider

antibodies-online

Product name

anti-serine Palmitoyltransferase, Long Chain Base Subunit 1 (SPTLC1) (N-Term) antibody

Antibody type

Polyclonal

Description

Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Reactivity

Human, Mouse

Host

Rabbit

Epitope

N-Term

Vial size

0.4 mL

Storage

Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.

Handling

Avoid repeated freezing and thawing.

References

Submitted references

Permeability barrier disruption increases the level of serine palmitoyltransferase in human epidermis.

Stachowitz S, Alessandrini F, Abeck D, Ring J, Behrendt H
The Journal of investigative dermatology 2002 Nov;119(5):1048-52

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Hereditary sensory neuropathy type I: haplotype analysis shows founders in southern England and Europe.

Nicholson GA, Dawkins JL, Blair IP, Auer-Grumbach M, Brahmbhatt SB, Hulme DJ
American journal of human genetics 2001 Sep;69(3):655-9

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Mutations in SPTLC1, encoding serine palmitoyltransferase, long chain base subunit-1, cause hereditary sensory neuropathy type I.

Dawkins JL, Hulme DJ, Brahmbhatt SB, Auer-Grumbach M, Nicholson GA
Nature genetics 2001 Mar;27(3):309-12

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SPTLC1 is mutated in hereditary sensory neuropathy, type 1.

Bejaoui K, Wu C, Scheffler MD, Haan G, Ashby P, Wu L, de Jong P, Brown RH Jr
Nature genetics 2001 Mar;27(3):261-2

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Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis.

Perry DK, Carton J, Shah AK, Meredith F, Uhlinger DJ, Hannun YA
The Journal of biological chemistry 2000 Mar 24;275(12):9078-84