19112-1-AP

antibody from Proteintech Group

Targeting: GOLPH3 GOPP1, GPP34, MIDAS, Vps74

Provider product page for 19112-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [23]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]
Immunohistochemistry [2]

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Product number: 19112-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#19112-1-AP, RRID:AB_2113342
Product name: GOLPH3 antibody
Antibody type: Polyclonal
Description: KD/KO validated GOLPH3 antibody (Cat. #19112-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

GOLPH3 protein structure - 19112-1-AP shown in red.

Submitted references Impaired Glycosylation of Gastric Mucins Drives Gastric Tumorigenesis and Serves as a Novel Therapeutic Target.

Arai J, Hayakawa Y, Tateno H, Murakami K, Hayashi T, Hata M, Matsushita Y, Kinoshita H, Abe S, Kurokawa K, Oya Y, Tsuboi M, Ihara S, Niikura R, Suzuki N, Iwata Y, Shiokawa T, Shiomi C, Uekura C, Yamamoto K, Fujiwara H, Kawamura S, Nakagawa H, Mizuno S, Kudo T, Takahashi S, Ushiku T, Hirata Y, Fujii C, Nakayama J, Shibata S, Woods S, Worthley DL, Hatakeyama M, Wang TC, Fujishiro M
Gastroenterology 2024 Aug;167(3):505-521.e19

CENPK orchestrates ovarian cancer progression via GOLPH3-Mediated activation of mTOR signaling.

Li G, Shen J, Cheng W, Wang X, Wang D, Song Y, Chen Y, Li X, Zhang M, Ding Y, Ma X, Qian Q, Zhang G, Ji J, Liu B
Molecular and cellular endocrinology 2024 Aug 1;589:112253

GOLPH3 promotes endotoxemia-induced liver and kidney injury through Golgi stress-mediated apoptosis and inflammatory response.

Dusabimana T, Je J, Yun SP, Kim HJ, Kim H, Park SW
Cell death & disease 2023 Jul 21;14(7):458

Long Intergenic Noncoding RNA 00641 Promotes Growth and Invasion of Colorectal Cancer through Regulating miR-450b-5p/GOLPH3 Axis.

Hong Z, Pan J, Chen M, Deng X, Chen Z, Wang C, Qiu C
Journal of oncology 2022;2022:8259135

Golgi phosphoprotein 3 induces autophagy and epithelial-mesenchymal transition to promote metastasis in colon cancer.

Gong LY, Tu T, Zhu J, Hu AP, Song JW, Huang JQ, Yang Y, Zhu Z, Chen Y
Cell death discovery 2022 Feb 21;8(1):76

Circular GOLPH3 RNA exerts oncogenic effects in vitro by regulating the miRNA-1299/LIF axis in oral squamous cell carcinoma.

Zou C, Li X, Wei H, Wu S, Song J, Tang Z, Luo H, Lv X, Ai Y
Bioengineered 2022 Apr;13(4):11012-11025

GOLPH3/CKAP4 promotes metastasis and tumorigenicity by enhancing the secretion of exosomal WNT3A in non-small-cell lung cancer.

Song JW, Zhu J, Wu XX, Tu T, Huang JQ, Chen GZ, Liang LY, Zhou CH, Xu X, Gong LY
Cell death & disease 2021 Oct 21;12(11):976

Golgi phosphoprotein 3 promotes the proliferation of gallbladder carcinoma cells via regulation of the NLRP3 inflammasome.

Zhu Z, Zhu Q, Cai D, Chen L, Xie W, Bai Y, Luo K
Oncology reports 2021 Jun;45(6)

Tankyrase-1-mediated degradation of Golgin45 regulates glycosyltransferase trafficking and protein glycosylation in Rab2-GTP-dependent manner.

Yue X, Tiwari N, Zhu L, Ngo HDT, Lim JM, Gim B, Jing S, Wang Y, Qian Y, Lee I
Communications biology 2021 Dec 7;4(1):1370

APOL1 C-Terminal Variants May Trigger Kidney Disease through Interference with APOL3 Control of Actomyosin.

Uzureau S, Lecordier L, Uzureau P, Hennig D, Graversen JH, Homblé F, Mfutu PE, Oliveira Arcolino F, Ramos AR, La Rovere RM, Luyten T, Vermeersch M, Tebabi P, Dieu M, Cuypers B, Deborggraeve S, Rabant M, Legendre C, Moestrup SK, Levtchenko E, Bultynck G, Erneux C, Pérez-Morga D, Pays E
Cell reports 2020 Mar 17;30(11):3821-3836.e13

A Novel Micropeptide Encoded by Y-Linked LINC00278 Links Cigarette Smoking and AR Signaling in Male Esophageal Squamous Cell Carcinoma.

Wu S, Zhang L, Deng J, Guo B, Li F, Wang Y, Wu R, Zhang S, Lu J, Zhou Y
Cancer research 2020 Jul 1;80(13):2790-2803

FAP-a and GOLPH3 Are Hallmarks of DCIS Progression to Invasive Breast Cancer.

Yu LN, Liu Z, Tian Y, Zhao PP, Hua X
Frontiers in oncology 2019;9:1424

STK25-induced inhibition of aerobic glycolysis via GOLPH3-mTOR pathway suppresses cell proliferation in colorectal cancer.

Wu F, Gao P, Wu W, Wang Z, Yang J, Di J, Jiang B, Su X
Journal of experimental & clinical cancer research : CR 2018 Jul 11;37(1):144

CENPH Inhibits Rapamycin Sensitivity by Regulating GOLPH3-dependent mTOR Signaling Pathway in Colorectal Cancer.

Wu W, Wu F, Wang Z, Di J, Yang J, Gao P, Jiang B, Su X
Journal of Cancer 2017;8(12):2163-2172

miR34a/GOLPH3 Axis abrogates Urothelial Bladder Cancer Chemoresistance via Reduced Cancer Stemness.

Zhang Q, Zhuang J, Deng Y, Yang L, Cao W, Chen W, Lin T, Lv X, Yu H, Xue Y, Guo H
Theranostics 2017;7(19):4777-4790

Re-evaluating the roles of myosin 18Aα and F-actin in determining Golgi morphology.

Bruun K, Beach JR, Heissler SM, Remmert K, Sellers JR, Hammer JA
Cytoskeleton (Hoboken, N.J.) 2017 May;74(5):205-218

GOLPH3 induces epithelial-mesenchymal transition via Wnt/β-catenin signaling pathway in epithelial ovarian cancer.

Sun J, Yang X, Zhang R, Liu S, Gan X, Xi X, Zhang Z, Feng Y, Sun Y
Cancer medicine 2017 Apr;6(4):834-844

GOLPH3 is a potential therapeutic target and a prognostic indicator of poor survival in bladder cancer treated by cystectomy.

Zhang Q, Zhuang J, Deng Y, Zhao X, Tang B, Yao D, Zhao W, Chang C, Lu Q, Chen W, Zhang S, Ji C, Cao L, Guo H
Oncotarget 2015 Oct 13;6(31):32177-92

GOLPH3 high expression predicts poor prognosis in patients with resected non-small cell lung cancer: an immunohistochemical analysis.

Zhang Y, Ma M, Han B
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2014 Nov;35(11):10833-9

GOLPH3 predicts survival of colorectal cancer patients treated with 5-fluorouracil-based adjuvant chemotherapy.

Wang Z, Jiang B, Chen L, Di J, Cui M, Liu M, Ma Y, Yang H, Xing J, Zhang C, Yao Z, Zhang N, Dong B, Ji J, Su X
Journal of translational medicine 2014 Jan 21;12:15

GOLPH3 is a novel marker of poor prognosis and a potential therapeutic target in human renal cell carcinoma.

Xue Y, Wu G, Liao Y, Xiao G, Ma X, Zou X, Zhang G, Xiao R, Wang X, Liu Q, Long D, Yang J, Xu H, Liu F, Liu M, Xie K, Huang R
British journal of cancer 2014 Apr 29;110(9):2250-60

Overexpression of GOLPH3 is associated with poor clinical outcome in gastric cancer.

Hu BS, Hu H, Zhu CY, Gu YL, Li JP
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2013 Feb;34(1):515-20

Increased expression of Golgi phosphoprotein-3 is associated with tumor aggressiveness and poor prognosis of prostate cancer.

Hua X, Yu L, Pan W, Huang X, Liao Z, Xian Q, Fang L, Shen H
Diagnostic pathology 2012 Sep 24;7:127

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HeLa cells were subjected to SDS PAGE followed by western blot with 19112-1-AP(GOLPH3 antibody) at dilution of 1:500
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The GOLPH3 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human GOLPH3. This antibody recognizes human,mouse,rat antigen. The GOLPH3 antibody has been validated for the following applications: ELISA, WB, IHC, IF analysis.
Appendix: 19112-1-AP.pdf

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human placenta using 19112-1-AP(GOLPH3 antibody) at dilution of 1:100 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human placenta using 19112-1-AP(GOLPH3 antibody) at dilution of 1:100 (under 40x lens)
Sample type: tissue