Antibody data
- Antibody Data
- Antigen structure
- References [2]
- Comments [0]
- Validations
- Blocking/Neutralizing [1]
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Validation data
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- Product number
- MAB608-100 - Provider product page
- Provider
- R&D Systems
- Product name
- Human Flt-3 Ligand/FLT3L Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from ascites. Detects human Flt-3 Ligand/FLT3L in Western blots.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Antigen sequence
AAA17999
- Isotype
- IgG
- Antibody clone number
- 40416
- Vial size
- 100 ug
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references Efficacy and safety of CDX-301, recombinant human Flt3L, at expanding dendritic cells and hematopoietic stem cells in healthy human volunteers.
Fibroblasts from human spleen regulate NK cell differentiation from blood CD34(+) progenitors via cell surface IL-15.
Anandasabapathy N, Breton G, Hurley A, Caskey M, Trumpfheller C, Sarma P, Pring J, Pack M, Buckley N, Matei I, Lyden D, Green J, Hawthorne T, Marsh HC, Yellin M, Davis T, Keler T, Schlesinger SJ
Bone marrow transplantation 2015 Jul;50(7):924-30
Bone marrow transplantation 2015 Jul;50(7):924-30
Fibroblasts from human spleen regulate NK cell differentiation from blood CD34(+) progenitors via cell surface IL-15.
Briard D, Brouty-Boyé D, Azzarone B, Jasmin C
Journal of immunology (Baltimore, Md. : 1950) 2002 May 1;168(9):4326-32
Journal of immunology (Baltimore, Md. : 1950) 2002 May 1;168(9):4326-32
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Supportive validation
- Submitted by
- R&D Systems (provider)
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- Experimental details
- Cell Proliferation Induced by Flt-3 Ligand and Neutral-ization by Human Flt-3 Ligand Antibody. Recombinant Human Flt-3 Ligand (Catalog # 308-FK) stimulates proliferation in BaF3 mouse pro-B cell line transfected with mouse Flt-3 in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Human Flt-3 Ligand (1 ng/mL) is neutralized (green line) by increasing concentrations of Mouse Anti-Human Flt-3 Ligand Monoclonal Antibody (Catalog # MAB608). The ND50 is typically 0.02-0.06 µg/mL.