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Western blot
Blocking/NeutralizingAntibody data
- Antibody Data
- Antigen structure
- References [3]
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- Validations
- Blocking/Neutralizing [1]
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- Product number
- MAB308-100 - Provider product page
- Provider
- R&D Systems
- Product name
- Human Flt-3 Ligand/FLT3L Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from ascites. Detects human Flt-3 Ligand/FLT3L in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant mouse Flt-3 Ligand/FLT3L is observed.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Antigen sequence
AAA17999- Isotype
- IgG
- Antibody clone number
- 40406
- Vial size
- 100 ug
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references Targeting the binding interface on a shared receptor subunit of a cytokine family enables the inhibition of multiple member cytokines with selectable target spectrum.
Long-term maintenance of gp120-specific immune responses by genetic vaccination with the HIV-1 envelope genes linked to the gene encoding Flt-3 ligand.
Peritonitis in the baboon: a primate model which stimulates human sepsis.
Nata T, Basheer A, Cocchi F, van Besien R, Massoud R, Jacobson S, Azimi N, Tagaya Y
The Journal of biological chemistry 2015 Sep 11;290(37):22338-51
The Journal of biological chemistry 2015 Sep 11;290(37):22338-51
Long-term maintenance of gp120-specific immune responses by genetic vaccination with the HIV-1 envelope genes linked to the gene encoding Flt-3 ligand.
Sailaja G, Husain S, Nayak BP, Jabbar AM
Journal of immunology (Baltimore, Md. : 1950) 2003 Mar 1;170(5):2496-507
Journal of immunology (Baltimore, Md. : 1950) 2003 Mar 1;170(5):2496-507
Peritonitis in the baboon: a primate model which stimulates human sepsis.
Kinasewitz GT, Chang AC, Peer GT, Hinshaw LB, Taylor FB Jr
Shock (Augusta, Ga.) 2000 Feb;13(2):100-9
Shock (Augusta, Ga.) 2000 Feb;13(2):100-9
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Supportive validation
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- R&D Systems (provider)
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- Experimental details
- Cell Proliferation Induced by Flt-3 Ligand and Neutralization by Human Flt-3 Ligand Antibody. Recombinant Human Flt-3 Ligand (Catalog # 308-FK or 308-FKN) stimulates proliferation in the BaF3 mouse pro-B cell line transfected with mouse Flt-3 in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Human Flt-3 Ligand (5 ng/mL) is neutralized (green line) by increasing concentrations of Human Flt-3 Ligand Monoclonal Antibody (Catalog # MAB308). The ND50 is typically 0.02-0.06 µg/mL.
