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- Antigen structure
- References [20]
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- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 16424-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#16424-1-AP, RRID:AB_2079500
- Product name
- CHMP7 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated CHMP7 antibody (Cat. #16424-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references ER-tethering directs TREX1 penetration of a BAF-dependent barrier at micronuclei.
Reduced CHMP7 Expression Compromises Telomere Integrity in Mammalian Cells.
Molecular and subcellular mechanisms of vital macrophage extracellular trap formation.
Pathological α-synuclein perturbs nuclear integrity.
Pathological α-Synuclein Perturbs Nuclear Integrity.
Charged multivesicular body protein 7 was identified as a prognostic biomarker correlated with metastasis in colorectal cancer.
LRRC59 cooperates with nuclear transporters to restrain the nuclear envelope repair machinery and safeguard genome integrity.
TEX264 drives selective autophagy of DNA lesions to promote DNA repair and cell survival.
Altered nuclear envelope homeostasis is a key pathogenic event in C9ORF72-linked ALS/FTD.
VPS4B orchestrates response to nuclear envelope stress by regulating ESCRT-III dynamics in glioblastoma.
Inhibition of RNA splicing triggers CHMP7 nuclear entry, impacting TDP-43 function and leading to the onset of ALS cellular phenotypes.
A p62-dependent rheostat dictates micronuclei catastrophe and chromosome rearrangements.
Identification of CHMP7 as a promising immunobiomarker for immunotherapy and chemotherapy and impact on prognosis of colorectal cancer patients.
Cellular ESCRT components are recruited to regulate the endocytic trafficking and RNA replication compartment assembly during classical swine fever virus infection.
CDK1 controls CHMP7-dependent nuclear envelope reformation.
The ESCRT machinery counteracts Nesprin-2G-mediated mechanical forces during nuclear envelope repair.
Unrestrained ESCRT-III drives micronuclear catastrophe and chromosome fragmentation.
Repair of nuclear ruptures requires barrier-to-autointegration factor.
CC2D1B Coordinates ESCRT-III Activity during the Mitotic Reformation of the Nuclear Envelope.
Membrane Binding by CHMP7 Coordinates ESCRT-III-Dependent Nuclear Envelope Reformation.
Chen Y, Norman RX, Toufektchan E, Luan X, Shim A, Rosenberg H, Kovacs MT, Nichols A, Hickling J, Cifani P, Kentsis A, Zhou W, Maciejowski J
Molecular cell 2026 Mar 19;86(6):1099-1115.e10
Molecular cell 2026 Mar 19;86(6):1099-1115.e10
Reduced CHMP7 Expression Compromises Telomere Integrity in Mammalian Cells.
Burla R, La Torre M, Maccaroni K, Tacconi S, Dini L, Saggio I
Cells 2026 Jan 29;15(3)
Cells 2026 Jan 29;15(3)
Molecular and subcellular mechanisms of vital macrophage extracellular trap formation.
Lee Y, Brenner M, Aziz M, Wang P
Frontiers in immunology 2025;16:1608428
Frontiers in immunology 2025;16:1608428
Pathological α-synuclein perturbs nuclear integrity.
Millett M, Comite A, Castosa EM, Heuberger A, Wagner P, Gallardo I, Reinhardt J, Chambers N, Hall D, Miller E, Nabert D, Balsamo B, Prokop S, Moehle M
Neurobiology of disease 2025 Oct 1;214:107028
Neurobiology of disease 2025 Oct 1;214:107028
Pathological α-Synuclein Perturbs Nuclear Integrity.
Millett M, Comite A, Castosa EM, Heuberger A, Wagner P, Gallardo I, Reinhardt J, Chambers N, Hall D, Miller E, Nabert D, Balsamo B, Prokop S, Moehle M
bioRxiv : the preprint server for biology 2025 May 1;
bioRxiv : the preprint server for biology 2025 May 1;
Charged multivesicular body protein 7 was identified as a prognostic biomarker correlated with metastasis in colorectal cancer.
Wei JR, Ouyang YN, Tang MT, Yuan JZ, Wang PL, Jiang LH, Wu LC
World journal of gastrointestinal oncology 2025 Jun 15;17(6):105967
World journal of gastrointestinal oncology 2025 Jun 15;17(6):105967
LRRC59 cooperates with nuclear transporters to restrain the nuclear envelope repair machinery and safeguard genome integrity.
Timmer R, Bellanger A, Peeters S, Kim H, de la Ballina LR, Eikvar S, Arns AJ, Oortgijs E, Sekulić N, De Vos WH, Campsteijn C
Nature communications 2025 Dec 12;16(1):11211
Nature communications 2025 Dec 12;16(1):11211
TEX264 drives selective autophagy of DNA lesions to promote DNA repair and cell survival.
Lascaux P, Hoslett G, Tribble S, Trugenberger C, Antičević I, Otten C, Torrecilla I, Koukouravas S, Zhao Y, Yang H, Aljarbou F, Ruggiano A, Song W, Peron C, Deangeli G, Domingo E, Bancroft J, Carrique L, Johnson E, Vendrell I, Fischer R, Ng AWT, Ngeow J, D'Angiolella V, Raimundo N, Maughan T, Popović M, Milošević I, Ramadan K
Cell 2024 Oct 3;187(20):5698-5718.e26
Cell 2024 Oct 3;187(20):5698-5718.e26
Altered nuclear envelope homeostasis is a key pathogenic event in C9ORF72-linked ALS/FTD.
Sirtori R, Gregoire M, Collins A, Santangelo S, Chatragadda B, Cullen R, Ratti A, Fallini C
bioRxiv : the preprint server for biology 2024 Feb 4;
bioRxiv : the preprint server for biology 2024 Feb 4;
VPS4B orchestrates response to nuclear envelope stress by regulating ESCRT-III dynamics in glioblastoma.
Wu Z, Omura I, Saito A, Imaizumi K, Kamikawa Y
Nucleus (Austin, Tex.) 2024 Dec;15(1):2423660
Nucleus (Austin, Tex.) 2024 Dec;15(1):2423660
Inhibition of RNA splicing triggers CHMP7 nuclear entry, impacting TDP-43 function and leading to the onset of ALS cellular phenotypes.
Al-Azzam N, To JH, Gautam V, Street LA, Nguyen CB, Naritomi JT, Lam DC, Madrigal AA, Lee B, Jin W, Avina A, Mizrahi O, Mueller JR, Ford W, Schiavon CR, Rebollo E, Vu AQ, Blue SM, Madakamutil YL, Manor U, Rothstein JD, Coyne AN, Jovanovic M, Yeo GW
Neuron 2024 Dec 18;112(24):4033-4047.e8
Neuron 2024 Dec 18;112(24):4033-4047.e8
A p62-dependent rheostat dictates micronuclei catastrophe and chromosome rearrangements.
Martin S, Scorzoni S, Cordone S, Mazzagatti A, Beznoussenko GV, Gunn AL, Di Bona M, Eliezer Y, Leor G, Ben-Yishay T, Loffreda A, Cancila V, Rainone MC, Ippolito MR, Martis V, Bedin F, Garrè M, Vaites LP, Vasapolli P, Polo S, Parazzoli D, Tripodo C, Mironov AA, Cuomo A, Ben-David U, Bakhoum SF, Hatch EM, Ly P, Santaguida S
Science (New York, N.Y.) 2024 Aug 30;385(6712):eadj7446
Science (New York, N.Y.) 2024 Aug 30;385(6712):eadj7446
Identification of CHMP7 as a promising immunobiomarker for immunotherapy and chemotherapy and impact on prognosis of colorectal cancer patients.
Guo Y, Wang S, Liang F, Wang M
Frontiers in cell and developmental biology 2023;11:1211843
Frontiers in cell and developmental biology 2023;11:1211843
Cellular ESCRT components are recruited to regulate the endocytic trafficking and RNA replication compartment assembly during classical swine fever virus infection.
Liu CC, Liu YY, Zhou JF, Chen X, Chen H, Hu JH, Chen J, Zhang J, Sun RC, Wei JC, Go YY, Morita E, Zhou B
PLoS pathogens 2022 Feb;18(2):e1010294
PLoS pathogens 2022 Feb;18(2):e1010294
CDK1 controls CHMP7-dependent nuclear envelope reformation.
Gatta AT, Olmos Y, Stoten CL, Chen Q, Rosenthal PB, Carlton JG
eLife 2021 Jul 21;10
eLife 2021 Jul 21;10
The ESCRT machinery counteracts Nesprin-2G-mediated mechanical forces during nuclear envelope repair.
Wallis SS, Ventimiglia LN, Otigbah E, Infante E, Cuesta-Geijo MA, Kidiyoor GR, Carbajal MA, Fleck RA, Foiani M, Garcia-Manyes S, Martin-Serrano J, Agromayor M
Developmental cell 2021 Dec 6;56(23):3192-3202.e8
Developmental cell 2021 Dec 6;56(23):3192-3202.e8
Unrestrained ESCRT-III drives micronuclear catastrophe and chromosome fragmentation.
Vietri M, Schultz SW, Bellanger A, Jones CM, Petersen LI, Raiborg C, Skarpen E, Pedurupillay CRJ, Kjos I, Kip E, Timmer R, Jain A, Collas P, Knorr RL, Grellscheid SN, Kusumaatmaja H, Brech A, Micci F, Stenmark H, Campsteijn C
Nature cell biology 2020 Jul;22(7):856-867
Nature cell biology 2020 Jul;22(7):856-867
Repair of nuclear ruptures requires barrier-to-autointegration factor.
Halfmann CT, Sears RM, Katiyar A, Busselman BW, Aman LK, Zhang Q, O'Bryan CS, Angelini TE, Lele TP, Roux KJ
The Journal of cell biology 2019 Jul 1;218(7):2136-2149
The Journal of cell biology 2019 Jul 1;218(7):2136-2149
CC2D1B Coordinates ESCRT-III Activity during the Mitotic Reformation of the Nuclear Envelope.
Ventimiglia LN, Cuesta-Geijo MA, Martinelli N, Caballe A, Macheboeuf P, Miguet N, Parnham IM, Olmos Y, Carlton JG, Weissenhorn W, Martin-Serrano J
Developmental cell 2018 Dec 3;47(5):547-563.e6
Developmental cell 2018 Dec 3;47(5):547-563.e6
Membrane Binding by CHMP7 Coordinates ESCRT-III-Dependent Nuclear Envelope Reformation.
Olmos Y, Perdrix-Rosell A, Carlton JG
Current biology : CB 2016 Oct 10;26(19):2635-2641
Current biology : CB 2016 Oct 10;26(19):2635-2641
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 16424-1-AP(CHMP7 antibody) at dilution of 1:1200
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 16424-1-AP(CHMP7 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The CHMP7 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human CHMP7. This antibody recognizes human, mouse, rat antigen. The CHMP7 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
