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- Antigen structure
- References [40]
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- Product number
- 14195-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14195-1-AP, RRID:AB_2190723
- Product name
- CAT-1 antibody
- Antibody type
- Polyclonal
- Description
- CAT-1 antibody (Cat. #14195-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Establishment of a m(6)A-Related Molecular Pattern in the Prognosis and Immune Infiltration of Osteosarcoma Using Machine Learning and Experiments.
The lncRNA DAMER selectively guides m(6)A-dependent regulation of ATF4 and asparagine metabolism under nutrient stress in cancer.
Preclinical Comparison of (18)F-Labeled Amino Acids Targeting Different Transporter Systems for PET Imaging of Triple-Negative Breast Cancer.
Radiation-triggerable bioreactors enable bioenergetic reprograming of cancer stem cell plasticity via targeted arginine metabolism disruption for augmented radio-immunotherapy.
Arginine Deprivation Induces Quiescence and Confers Vulnerability to Ferroptosis in Colorectal Cancer.
Micropeptide hSPAR regulates glutamine levels and suppresses mammary tumor growth via a TRIM21-P27KIP1-mTOR axis.
Hypoxia-Inducible Factor HIF1α Regulates the Expression of SLC7A1 to Mediate Erastin-Induced Ferroptosis in Cervical Cancer Cells.
Gut bacterial L-lysine alters metabolism and histone methylation to drive dendritic cell tolerance.
Single-cell profiling of SLC family transporters: uncovering the role of SLC7A1 in osteosarcoma.
Regulation of eco-tropic human immunodeficiency virus type-1-infection by sterile alpha motif and histidine-aspartic domain containing protein-1 in a microglial cell line: a novel in vitro model for studying HIV infection and latency in microglia.
Targeting spermine metabolism to overcome immunotherapy resistance in pancreatic cancer.
CTPAD: an interactive web application for comprehensive transcriptomic profiling in allergic diseases.
High expression of SLC7A1 in high-grade serous ovarian cancer promotes tumor progression and is involved in MAPK/ERK pathway and EMT.
Integrated analysis and validation of TRIM23/p53 signaling pathway in hepatic stellate cells ferroptosis and liver fibrosis.
Polyvinylpyrrolidone-Polydatin nanoparticles protect against oxaliplatin induced intestinal toxicity in vitro and in vivo.
Cold plasma-treated medium preferentially eliminates doxorubicin-resistant osteosarcoma cells.
Alleviative Effect of Probiotic Ferment on Lawsonia intracellularis Infection in Piglets.
SLC7A1 Overexpression Is Involved in Energy Metabolism Reprogramming to Induce Tumor Progression in Epithelial Ovarian Cancer and Is Associated with Immune-Infiltrating Cells.
Transcriptome and Proteome Analysis in LUHMES Cells Overexpressing Alpha-Synuclein.
GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis.
L-Theanine Regulates the Abundance of Amino Acid Transporters in Mice Duodenum and Jejunum via the mTOR Signaling Pathway.
Hypoxia Is a Dominant Remodeler of the Effector T Cell Surface Proteome Relative to Activation and Regulatory T Cell Suppression.
l-Theanine Ameliorates d-Galactose-Induced Brain Damage in Rats via Inhibiting AGE Formation and Regulating Sirtuin1 and BDNF Signaling Pathways.
An Inflammatory Response-Related Gene Signature Can Impact the Immune Status and Predict the Prognosis of Hepatocellular Carcinoma.
Colorectal Cancer-Derived CAT1-Positive Extracellular Vesicles Alter Nitric Oxide Metabolism in Endothelial Cells and Promote Angiogenesis.
In vivo CRISPR screening reveals nutrient signaling processes underpinning CD8(+) T cell fate decisions.
Prognostic and clinical significance of Solute Carrier Family 7 Member 1 in ovarian cancer.
Derangements of amino acids in cachectic skeletal muscle are caused by mitochondrial dysfunction.
S119N Mutation of the E3 Ubiquitin Ligase SPOP Suppresses SLC7A1 Degradation to Regulate Hepatoblastoma Progression.
Exogenous l-ARGININE does not stimulate production OF NO or cGMP within the rat corporal smooth muscle cells in culture.
Extracellular l-arginine Enhances Relaxations Induced by Opening of Calcium-Activated SKCa Channels in Porcine Retinal Arteriole.
The N-recognin UBR4 of the N-end rule pathway is required for neurogenesis and homeostasis of cell surface proteins.
The farnesoid X receptor agonist obeticholic acid upregulates biliary excretion of asymmetric dimethylarginine via MATE-1 during hepatic ischemia/reperfusion injury.
miRNA-145 is associated with spontaneous hypertension by targeting SLC7A1.
High glucose impaired estrogen receptor alpha signaling via β-catenin in osteoblastic MC3T3-E1.
MCD diet-induced steatohepatitis is associated with alterations in asymmetric dimethylarginine (ADMA) and its transporters.
Analysis of cationic amino acid transport activity in canine lens epithelial cells.
Insulin rapidly stimulates L-arginine transport in human aortic endothelial cells via Akt.
Culture medium, gas atmosphere and MAPK inhibition affect regulation of RNA-binding protein targets during mouse preimplantation development.
Pseudotype-dependent lentiviral transduction of astrocytes or neurons in the rat substantia nigra.
He N, Chen X, Zhang C
International journal of genomics 2026;2026:2000690
International journal of genomics 2026;2026:2000690
The lncRNA DAMER selectively guides m(6)A-dependent regulation of ATF4 and asparagine metabolism under nutrient stress in cancer.
Tao T, Feng X, Yang Y, Liu B, Liang J, Chen Z, Wang S, Zhao J, Yang X, Huo L, Zhang Y, Gan Z, Wu W, Zeng J, Huang Y, Ye Y, Xu X, Yu J, Hong R, Guan H, Wu J, Xia L, He W, Li B, Cai J, Li M
Nature cell biology 2026 Apr;28(4):797-811
Nature cell biology 2026 Apr;28(4):797-811
Preclinical Comparison of (18)F-Labeled Amino Acids Targeting Different Transporter Systems for PET Imaging of Triple-Negative Breast Cancer.
Akca U, Song PN, Devalankar D, Yasui N, Sorace AG, McConathy J
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2026 Apr 1;67(4):534-541
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2026 Apr 1;67(4):534-541
Radiation-triggerable bioreactors enable bioenergetic reprograming of cancer stem cell plasticity via targeted arginine metabolism disruption for augmented radio-immunotherapy.
Yao X, Yang H, Guo S, Liu Y, Zhang Q, Zhou Z, Li M, Luo Z
Biomaterials 2025 Nov;322:123391
Biomaterials 2025 Nov;322:123391
Arginine Deprivation Induces Quiescence and Confers Vulnerability to Ferroptosis in Colorectal Cancer.
Lin Y, Zhang Y, Huang T, Chen J, Li G, Zhang B, Xu L, Wang K, He H, Chen H, Liu D, Guo S, He X, Lan P
Cancer research 2025 May 2;85(9):1663-1679
Cancer research 2025 May 2;85(9):1663-1679
Micropeptide hSPAR regulates glutamine levels and suppresses mammary tumor growth via a TRIM21-P27KIP1-mTOR axis.
Huang Y, Lu H, Liu Y, Wang J, Xia Q, Shi X, Jin Y, Liang X, Wang W, Ma X, Wang Y, Gong M, Li C, Cang C, Cui Q, Chen C, Shen T, Liu L, Wang X
The EMBO journal 2025 Mar;44(5):1414-1441
The EMBO journal 2025 Mar;44(5):1414-1441
Hypoxia-Inducible Factor HIF1α Regulates the Expression of SLC7A1 to Mediate Erastin-Induced Ferroptosis in Cervical Cancer Cells.
Huang Y, Lei Y, Li Y
The journal of gene medicine 2025 Jul;27(7):e70027
The journal of gene medicine 2025 Jul;27(7):e70027
Gut bacterial L-lysine alters metabolism and histone methylation to drive dendritic cell tolerance.
Tang Q, Fan G, Peng X, Sun X, Kong X, Zhang L, Zhang C, Liu Y, Yang J, Yu K, Miao C, Yao Z, Li L, Zhang ZS, Wang Q
Cell reports 2025 Jan 28;44(1):115125
Cell reports 2025 Jan 28;44(1):115125
Single-cell profiling of SLC family transporters: uncovering the role of SLC7A1 in osteosarcoma.
Liao Y, Chen J, Yao H, Zheng T, Tu J, Chen W, Guo Z, Zou Y, Wen L, Xie X
Journal of translational medicine 2025 Jan 22;23(1):103
Journal of translational medicine 2025 Jan 22;23(1):103
Regulation of eco-tropic human immunodeficiency virus type-1-infection by sterile alpha motif and histidine-aspartic domain containing protein-1 in a microglial cell line: a novel in vitro model for studying HIV infection and latency in microglia.
Ostermeier B, Halpern C, Maggirwar SB
Journal of neurovirology 2025 Dec;31(6):507-518
Journal of neurovirology 2025 Dec;31(6):507-518
Targeting spermine metabolism to overcome immunotherapy resistance in pancreatic cancer.
Yang H, Zhang X, Zhang S, Yang Y, Chen Y, Jiang Y, Lu Q, Liu L, Lao M, Du W, Sun K, He L, Shi J, Liu X, Song J, Lu N, Huang J, Huang J, Zhou R, Lu X, Liang T, Bai X
Nature communications 2025 Aug 22;16(1):7827
Nature communications 2025 Aug 22;16(1):7827
CTPAD: an interactive web application for comprehensive transcriptomic profiling in allergic diseases.
Zhou S, Huang W, Liu Y, Luo P, Lin A, Yang H, Qiu Q
Journal of translational medicine 2024 Oct 14;22(1):935
Journal of translational medicine 2024 Oct 14;22(1):935
High expression of SLC7A1 in high-grade serous ovarian cancer promotes tumor progression and is involved in MAPK/ERK pathway and EMT.
You S, Han X, Xu Y, Sui L, Song K, Yao Q
Cancer medicine 2024 May;13(10):e7217
Cancer medicine 2024 May;13(10):e7217
Integrated analysis and validation of TRIM23/p53 signaling pathway in hepatic stellate cells ferroptosis and liver fibrosis.
Chen J, Zhang R, Li F, Lin S, Wang J
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2024 Feb;56(2):281-290
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2024 Feb;56(2):281-290
Polyvinylpyrrolidone-Polydatin nanoparticles protect against oxaliplatin induced intestinal toxicity in vitro and in vivo.
Zhou S, Sun Y, Wang K, Gao X, Dong K, Wang J, Wu X, Guo C
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Feb;184:114427
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Feb;184:114427
Cold plasma-treated medium preferentially eliminates doxorubicin-resistant osteosarcoma cells.
Tornín J, Gallego B, Rey V, Murillo D, Huergo C, Rodríguez A, Canal C, Rodríguez R
Free radical biology & medicine 2023 Nov 20;209(Pt 1):127-134
Free radical biology & medicine 2023 Nov 20;209(Pt 1):127-134
Alleviative Effect of Probiotic Ferment on Lawsonia intracellularis Infection in Piglets.
Xu T, Guo Y, Zhang Y, Cao K, Zhou X, Qian M, Han X
Biology 2023 Jun 17;12(6)
Biology 2023 Jun 17;12(6)
SLC7A1 Overexpression Is Involved in Energy Metabolism Reprogramming to Induce Tumor Progression in Epithelial Ovarian Cancer and Is Associated with Immune-Infiltrating Cells.
You S, Zhu X, Yang Y, Du X, Song K, Zheng Q, Zeng P, Yao Q
Journal of oncology 2022;2022:5864826
Journal of oncology 2022;2022:5864826
Transcriptome and Proteome Analysis in LUHMES Cells Overexpressing Alpha-Synuclein.
Höllerhage M, Stepath M, Kohl M, Pfeiffer K, Chua OWH, Duan L, Hopfner F, Eisenacher M, Marcus K, Höglinger GU
Frontiers in neurology 2022;13:787059
Frontiers in neurology 2022;13:787059
GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis.
Cordova RA, Misra J, Amin PH, Klunk AJ, Damayanti NP, Carlson KR, Elmendorf AJ, Kim HG, Mirek ET, Elzey BD, Miller MJ, Dong XC, Cheng L, Anthony TG, Pili R, Wek RC, Staschke KA
eLife 2022 Sep 15;11
eLife 2022 Sep 15;11
L-Theanine Regulates the Abundance of Amino Acid Transporters in Mice Duodenum and Jejunum via the mTOR Signaling Pathway.
Liu K, Peng Y, Lin L, Gong Z, Xiao W, Li Y
Nutrients 2022 Dec 28;15(1)
Nutrients 2022 Dec 28;15(1)
Hypoxia Is a Dominant Remodeler of the Effector T Cell Surface Proteome Relative to Activation and Regulatory T Cell Suppression.
Byrnes JR, Weeks AM, Shifrut E, Carnevale J, Kirkemo L, Ashworth A, Marson A, Wells JA
Molecular & cellular proteomics : MCP 2022 Apr;21(4):100217
Molecular & cellular proteomics : MCP 2022 Apr;21(4):100217
l-Theanine Ameliorates d-Galactose-Induced Brain Damage in Rats via Inhibiting AGE Formation and Regulating Sirtuin1 and BDNF Signaling Pathways.
Zeng L, Lin L, Chen L, Xiao W, Gong Z
Oxidative medicine and cellular longevity 2021;2021:8850112
Oxidative medicine and cellular longevity 2021;2021:8850112
An Inflammatory Response-Related Gene Signature Can Impact the Immune Status and Predict the Prognosis of Hepatocellular Carcinoma.
Lin Z, Xu Q, Miao D, Yu F
Frontiers in oncology 2021;11:644416
Frontiers in oncology 2021;11:644416
Colorectal Cancer-Derived CAT1-Positive Extracellular Vesicles Alter Nitric Oxide Metabolism in Endothelial Cells and Promote Angiogenesis.
Ikeda A, Nagayama S, Sumazaki M, Konishi M, Fujii R, Saichi N, Muraoka S, Saigusa D, Shimada H, Sakai Y, Ueda K
Molecular cancer research : MCR 2021 May;19(5):834-846
Molecular cancer research : MCR 2021 May;19(5):834-846
In vivo CRISPR screening reveals nutrient signaling processes underpinning CD8(+) T cell fate decisions.
Huang H, Zhou P, Wei J, Long L, Shi H, Dhungana Y, Chapman NM, Fu G, Saravia J, Raynor JL, Liu S, Palacios G, Wang YD, Qian C, Yu J, Chi H
Cell 2021 Mar 4;184(5):1245-1261.e21
Cell 2021 Mar 4;184(5):1245-1261.e21
Prognostic and clinical significance of Solute Carrier Family 7 Member 1 in ovarian cancer.
Gong W, Chen Y, Zhang Y
Translational cancer research 2021 Feb;10(2):602-612
Translational cancer research 2021 Feb;10(2):602-612
Derangements of amino acids in cachectic skeletal muscle are caused by mitochondrial dysfunction.
Kunzke T, Buck A, Prade VM, Feuchtinger A, Prokopchuk O, Martignoni ME, Heisz S, Hauner H, Janssen KP, Walch A, Aichler M
Journal of cachexia, sarcopenia and muscle 2020 Feb;11(1):226-240
Journal of cachexia, sarcopenia and muscle 2020 Feb;11(1):226-240
S119N Mutation of the E3 Ubiquitin Ligase SPOP Suppresses SLC7A1 Degradation to Regulate Hepatoblastoma Progression.
He W, Zhang J, Liu B, Liu X, Liu G, Xie L, He J, Wei M, Li K, Ma J, Dong R, Ma D, Dong K, Ye M
Molecular therapy oncolytics 2020 Dec 16;19:149-162
Molecular therapy oncolytics 2020 Dec 16;19:149-162
Exogenous l-ARGININE does not stimulate production OF NO or cGMP within the rat corporal smooth muscle cells in culture.
Ferrini MG, Abraham A, Nguyen S, Luna R, Flores M, Artaza JN, Graciano L, Rajfer J
Nitric oxide : biology and chemistry 2019 Aug 1;89:64-70
Nitric oxide : biology and chemistry 2019 Aug 1;89:64-70
Extracellular l-arginine Enhances Relaxations Induced by Opening of Calcium-Activated SKCa Channels in Porcine Retinal Arteriole.
Simonsen U, Winther AK, Oliván-Viguera A, Comerma-Steffensen S, Köhler R, Bek T
International journal of molecular sciences 2019 Apr 25;20(8)
International journal of molecular sciences 2019 Apr 25;20(8)
The N-recognin UBR4 of the N-end rule pathway is required for neurogenesis and homeostasis of cell surface proteins.
Kim ST, Lee YJ, Tasaki T, Hwang J, Kang MJ, Yi EC, Kim BY, Kwon YT
PloS one 2018;13(8):e0202260
PloS one 2018;13(8):e0202260
The farnesoid X receptor agonist obeticholic acid upregulates biliary excretion of asymmetric dimethylarginine via MATE-1 during hepatic ischemia/reperfusion injury.
Ferrigno A, Di Pasqua LG, Berardo C, Siciliano V, Rizzo V, Adorini L, Richelmi P, Vairetti M
PloS one 2018;13(1):e0191430
PloS one 2018;13(1):e0191430
miRNA-145 is associated with spontaneous hypertension by targeting SLC7A1.
Wang Y, Jin L
Experimental and therapeutic medicine 2018 Jan;15(1):548-552
Experimental and therapeutic medicine 2018 Jan;15(1):548-552
High glucose impaired estrogen receptor alpha signaling via β-catenin in osteoblastic MC3T3-E1.
Wang R, Gao D, Zhou Y, Chen L, Luo B, Yu Y, Li H, Hu J, Huang Q, He M, Peng W, Luo D
The Journal of steroid biochemistry and molecular biology 2017 Nov;174:276-283
The Journal of steroid biochemistry and molecular biology 2017 Nov;174:276-283
MCD diet-induced steatohepatitis is associated with alterations in asymmetric dimethylarginine (ADMA) and its transporters.
Di Pasqua LG, Berardo C, Rizzo V, Richelmi P, Croce AC, Vairetti M, Ferrigno A
Molecular and cellular biochemistry 2016 Aug;419(1-2):147-55
Molecular and cellular biochemistry 2016 Aug;419(1-2):147-55
Analysis of cationic amino acid transport activity in canine lens epithelial cells.
Ochiai H, Moriyama J, Kanemaki N, Sato R, Onda K
Experimental animals 2013;62(4):311-7
Experimental animals 2013;62(4):311-7
Insulin rapidly stimulates L-arginine transport in human aortic endothelial cells via Akt.
Kohlhaas CF, Morrow VA, Jhakra N, Patil V, Connell JM, Petrie JR, Salt IP
Biochemical and biophysical research communications 2011 Sep 9;412(4):747-51
Biochemical and biophysical research communications 2011 Sep 9;412(4):747-51
Culture medium, gas atmosphere and MAPK inhibition affect regulation of RNA-binding protein targets during mouse preimplantation development.
Calder MD, Watson PH, Watson AJ
Reproduction (Cambridge, England) 2011 Nov;142(5):689-98
Reproduction (Cambridge, England) 2011 Nov;142(5):689-98
Pseudotype-dependent lentiviral transduction of astrocytes or neurons in the rat substantia nigra.
Cannon JR, Sew T, Montero L, Burton EA, Greenamyre JT
Experimental neurology 2011 Mar;228(1):41-52
Experimental neurology 2011 Mar;228(1):41-52
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse liver tissue were subjected to SDS PAGE followed by western blot with 14195-1-AP(SLC7A1 antibody) at dilution of 1:800
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The CAT-1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human CAT-1. This antibody recognizes human,mouse,rat antigen. The CAT-1 antibody has been validated for the following applications: ELISA, IHC, WB analysis.
