BS3560

antibody from Bioworld Technology, Inc

Targeting: IL5RA CD125, CDw125, IL5R

Immunohistochemistry

Antibody data

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Validation data

Product number: BS3560 - Provider product page
Provider: Bioworld Technology, Inc
Proper citation: Bioworld Technology Cat#BS3560, RRID:AB_1662016
Product name: IL 5RÏ« (K68) polyclonal antibody
Antibody type: Polyclonal
Antigen: Synthetic peptide, corresponding to amino acids 50-100 of Human IL-5RÏ«.
Description: Interleukin 5 (IL-5) is a soluble T cell-derived factor, also known as T cellreplacing factor (TRF), that induces B cell and eosinophil growth and differentiation. IL-5 exerts its biological activity through the IL-5 receptor (IL-5R),which is composed of two chains: an Ï« chain that binds IL-5 with low affinity and a ÉÇ chain that does not bind IL-5, but together with the IL-5 Ï« chain,constitutes the high affinity IL-5 receptor. The cytoplasmic domain of both the Ï« and ÉÇ chains is essential for signal transduction. Specifically, the membrane-proximal proline-rich sequence of the ytoplasmic domain of the IL-5R receptor Ï« subunit, IL-5RÏ«, is critical for the IL-5 induced proliferative response, expression of nuclear proto-oncogenes and tyrosine phosphorylation of cellular proteins, such as JAK1 and JAK2.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Isotype: IgG
Vial size: 100ul
Concentration: 1 mg/ml
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

IL5RA protein structure - BS3560 shown in red.