RA0398

antibody from Oursmab

Targeting: IL5RA CD125, CDw125, IL5R

Western blot (Supportive data in Antibodypedia)

ELISA (Supportive data in Antibodypedia)

Immunocytochemistry (Recommended by provider)

Flow cytometry (Recommended by provider)

Functional assay (Recommended by provider)

Antibody Data

Product number

RA0398

Provider

Oursmab

Product name

Benralizumab (Biosimilar Reference Antibody) (IL5RA)

Antibody type

Monoclonal

Description

Benralizumab is a humanized, afucosylated monoclonal antibody of the IgG1/kappa isotype approved for the add-on maintenance treatment of severe eosinophilic asthma. It specifically targets the interleukin-5 receptor alpha subunit (IL-5R¦Á). Unlike other anti-IL-5 biologics that neutralize the cytokine itself, benralizumab binds directly to IL-5R¦Á on eosinophils and basophils. Its afucosylated Fc region is engineered to dramatically enhance affinity for Fc¦ÃRIIIa receptors on natural killer (NK) cells and macrophages. This results in potent antibody-dependent cell-mediated cytotoxicity (ADCC), leading to rapid and near-complete depletion of eosinophils through apoptosis (programmed cell death).

Reactivity

Human

Isotype

IgG

Vial size

100 ¦Ìg,1 mg,5 mg,10 mg,25 mg,50 mg,100 mg

Concentration

Bottled at the concentration indicated on the vial.

Storage

Store at -20¡ãC or -80¡ãC. Avoid repeated freeze.

Western blot

Supportive validation

Submitted by

Oursmab (provider)

Main image

Experimental details

Benralizumab (Biosimilar Reference Antibody) (IL5RA)-RA0398-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.

ELISA

Supportive validation

Submitted by

Oursmab (provider)

Main image

Experimental details

ELISA plate pre-coated Antigen protein, can bind Benralizumab (Biosimilar Reference Antibody) (IL5RA)-RA0398 in a linear range of 3.91-500 ng/mL.