10713-1-AP

antibody from Proteintech Group

Targeting: TPI1

Provider product page for 10713-1-AP

Western blot

ELISA

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [54]
Comments [0]
Validations
Western blot [1]
Immunoprecipitation [1]

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Product number: 10713-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#10713-1-AP, RRID:AB_2207716
Product name: TPI1 antibody
Antibody type: Polyclonal
Description: KD/KO validated TPI1 antibody (Cat. #10713-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

TPI1 protein structure - 10713-1-AP shown in red.

Submitted references USP5-mediated CD73 deubiquitination drives osimertinib resistance via PI3K/AKT and glycolysis activation in LUAD.

Chen R, Han XH, Zhang Z, Han XJ, Xie J
iScience 2026 Mar 20;29(3):114916

Deubiquitination and stabilization of EIF4A3 by OTUB2 contributes to TPI1-mediated glycolysis and TNBC progression.

Wang Z, Chen X, Han X, Cao X, Wang X
Breast cancer research : BCR 2026 Mar 19;28(1)

Transcriptome-driven constraint-based modelling reveals metabolic targets for ovarian cancer.

Meeson KE, McGrail JC, Schwartz JM, Taylor SS
Cancer & metabolism 2026 Mar 19;14(1)

Adipose tissue-derived stromal cells enhance glycolytic metabolism in injured nerve cells via the FOXK1-HK2 axis for spinal cord injury repair.

Li F, Li H, Jia Y, Ou L, Fang Y, Pan L, Liu H, Ning B
Journal of translational medicine 2026 Mar 17;24(1)

Propofol Inhibits Lung Cancer Glycolysis by Influencing the Deubiquitination Modification of TPI1 Regulated by USP5.

Wang Y, Zhou H, Guo W, Xu J, Miao C
Biochemical genetics 2026 Jun;64(3):4317-4334

TPI1 promotes tumor progression and M2 macrophage polarization: Integrated pan-cancer and lung adenocarcinoma insights.

Liu X, Gao X, Ma R, Wang J, Zha T, Huang Y
Biochemical and biophysical research communications 2026 Jan 25;797:153099

GRK4 R65L causes salt-sensitive hypertension by augmenting renal Hao2-mediated oxidative stress via increasing the phosphorylation of TPI1 and promoting H3K27ac expression.

Zhang F, Wan J, Jiang L, Lin X, Chen L, Shao M, Chen J, Wang L, Zheng S, Ren H, Chen C, Jose PA, Zeng C, Yang J
Free radical biology & medicine 2026 Feb 16;244:464-481

HDAC11-Mediated Deacetylation of Triosephosphate Isomerase 1 Promotes Idiopathic Pulmonary Fibrosis.

Li Y, Shi X, Zhang F, Zhou X, Zhu X, Chen J, Fu K, Chen J, Yang J, Chen Z, Tong X, Zhao J, Li C
Research (Washington, D.C.) 2025;8:0953

LncRNA HANR promotes the aerobic glycolysis in prostate cancer by stabilizing TPI1.

Wang Z, Li X, Liu Z, Du Y, Wu T
Experimental cell research 2025 Sep 1;452(1):114744

Exon Skipping of Ste20-Like Kinase Enhances Glycolysis and Tumor Progression by Activating Enolase 1-Mediated Phosphoenolpyruvate Production.

Chen Z, Liao J, Zhu C, Chang R, Liang H, Ding Z, Huang Z, Chen X, Liang J, Zhang B
Cancer research 2025 Oct 15;85(20):3930-3948

Prognostic evaluation of glycolysis markers in hepatocellular carcinoma: insights from meta-analysis and multi-omics approaches.

Li G, Li Y, Zhou J, Tang S, Guo H, Lin J
BMC medical genomics 2025 Nov 8;18(1):179

Inhibition of TPI1 Sensitizes Cisplatin-Resistant Oral Cancer to Ferroptosis.

Wang D, Zheng H, Chen Y, Hao J, Zhou Y, Li N
Biomedicines 2025 May 19;13(5)

USP27 promotes glycolysis and hepatocellular carcinoma progression by stabilizing PFKFB3 through deubiquitination.

Xie L, Song D, Ouyang Z, Ning Y, Liu X, Li L, Xia W, Yang Y
Cellular signalling 2025 Mar;127:111585

Transcription factor ONECUT3 regulates HDAC6/HIF-1α activity to promote the Warburg effect and tumor growth in colorectal cancer.

Huo R, Li W, Wu H, He K, Wang H, Zhang S, Jiang SH, Li R, Xue J
Cell death & disease 2025 Mar 3;16(1):149

AMPK-regulated glycerol excretion maintains metabolic crosstalk between reductive and energetic stress.

Zhai X, Yang R, Chu Q, Guo Z, Hou P, Li X, Bai C, Lu Z, Qiao L, Fu Y, Niu J, Li B
Nature cell biology 2025 Jan;27(1):141-153

HSP90 co-regulates the formation and nuclear distribution of the glycolytic output complex to promote resistance and poor prognosis in gastric cancer patients.

Shen G, Liu S, Cao Y, Chen Z, Wang G, Yu L, Sun L, Ran Y
Journal of translational medicine 2025 Feb 10;23(1):172

Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles.

Sipes J, Zha D, Rayamajhi S, Bantis LE, Madan R, Mitra A, Puri RV, Rahman MM, Ahmmed F, Pathak HB, Russo A, Sardiu M, Isenberg BC, Cain BP, Coppeta J, Galhenage PM, Pathania S, David SM, Burdette JE, Godwin AK
Cancer research communications 2025 Aug 1;5(8):1266-1281

Identification of TPI1 As a potential therapeutic target in pancreatic cancer with dependency of TP53 mutation using multi-omics analysis.

Toyoda T, Miura N, Kato S, Masuda T, Ohashi R, Matsushita A, Matsuda F, Ohtsuki S, Katakura A, Honda K
Cancer science 2024 Nov;115(11):3622-3635

Protein expression patterns and metal metabolites in a protogynous hermaphrodite fish, the ricefield eel (Monopterus albus).

He Z, Xiao F, Yang D, Deng F, Ding W, He Z, Wang S, Chen Q, Wang H, Chen M, Gao K, Xiong J, Tang Z, Zhang M, Yan T
BMC genomics 2024 May 21;25(1):500

Nucleobase adducts bind MR1 and stimulate MR1-restricted T cells.

Vacchini A, Chancellor A, Yang Q, Colombo R, Spagnuolo J, Berloffa G, Joss D, Øyås O, Lecchi C, De Simone G, Beshirova A, Nosi V, Loureiro JP, Morabito A, De Gregorio C, Pfeffer M, Schaefer V, Prota G, Zippelius A, Stelling J, Häussinger D, Brunelli L, Villalta P, Lepore M, Davoli E, Balbo S, Mori L, De Libero G
Science immunology 2024 May 10;9(95):eadn0126

Dynamic changes of protein lactylation and their correlations with the glycolytic process during the postmortem acidification of broiler breast.

Wang Z, Xing T, Zhang L, Zhao L, Gao F
Poultry science 2024 Dec;103(12):104354

ELP3 stabilizes c-Myc to promote tumorigenesis.

Zhao W, Ouyang C, Huang C, Zhang J, Xiao Q, Zhang F, Wang H, Lin F, Wang J, Wang Z, Jiang B, Li Q
Journal of molecular cell biology 2024 Apr 4;15(9)

Purinergic receptor P2Y12 boosts autoimmune hepatitis through hexokinase 2-dependent glycolysis in T cells.

Zhuang W, Liu X, Liu G, Lv J, Qin H, Wang C, Xie L, Saimaier K, Han S, Shi C, Hua Q, Zhang R, Du C
International journal of biological sciences 2023;19(11):3576-3594

Small noncoding RNA interactome capture reveals pervasive, carbon source-dependent tRNA engagement of yeast glycolytic enzymes.

Asencio C, Schwarzl T, Sahadevan S, Hentze MW
RNA (New York, N.Y.) 2023 Mar;29(3):330-345

Effect of chronic heat stress on the carbonylation of glycolytic enzymes in breast muscle and its correlation with the growth performance of broilers.

Liu Y, Liu Z, Xing T, Li J, Zhang L, Zhao L, Gao F
Poultry science 2023 Dec;102(12):103103

LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung Adenocarcinoma.

Stein BD, Ferrarone JR, Gardner EE, Chang JW, Wu D, Hollstein PE, Liang RJ, Yuan M, Chen Q, Coukos JS, Sindelar M, Ngo B, Gross SS, Shaw RJ, Zhang C, Asara JM, Moellering RE, Varmus H, Cantley LC
Cancer discovery 2023 Apr 3;13(4):1002-1025

Alpha-solanine Anti-tumor Effects in Non-small Cell Lung Cancer Through Regulating the Energy Metabolism Pathway.

Zou T, Gu L, Yang L, Wei J, Zhao Y, Shen J, Li M, Wu X, Du F, Chen Y, Ye Y, Xiao Z, Wu Z
Recent patents on anti-cancer drug discovery 2022;17(4):396-409

Generation and Validation of an Anti-Human PANK3 Mouse Monoclonal Antibody.

Khadka S, Vien L, Leonard P, Bover L, Muller F
Biomolecules 2022 Sep 19;12(9)

TPI1 activates the PI3K/AKT/mTOR signaling pathway to induce breast cancer progression by stabilizing CDCA5.

Jin X, Wang D, Lei M, Guo Y, Cui Y, Chen F, Sun W, Chen X
Journal of translational medicine 2022 May 4;20(1):191

Identification of Glycolysis-Related lncRNAs and the Novel lncRNA WAC-AS1 Promotes Glycolysis and Tumor Progression in Hepatocellular Carcinoma.

Xia X, Zhang H, Xia P, Zhu Y, Liu J, Xu K, Yuan Y
Frontiers in oncology 2021;11:733595

Low chorionic villous succinate accumulation associates with recurrent spontaneous abortion risk.

Wang XH, Xu S, Zhou XY, Zhao R, Lin Y, Cao J, Zang WD, Tao H, Xu W, Li MQ, Zhao SM, Jin LP, Zhao JY
Nature communications 2021 Jun 8;12(1):3428

A long non-coding RNA specifically expressed in early embryos programs the metabolic balance in adult mice.

Zhu M, Wang Q, Tian P, Cheng L, Sun Z, Hong Q, Lv P, Ji L, Liu Y, Tang QQ, Wen B
Biochimica et biophysica acta. Molecular basis of disease 2021 Jan 1;1867(1):165988

Dietary fish oil supplement induces age-specific contractile and proteomic responses in muscles of male rats.

Russ DW, Dimova K, Morris E, Pacheco M, Garvey SM, Scordilis SP
Lipids in health and disease 2020 Jul 9;19(1):165

An enolase inhibitor for the targeted treatment of ENO1-deleted cancers.

Lin YH, Satani N, Hammoudi N, Yan VC, Barekatain Y, Khadka S, Ackroyd JJ, Georgiou DK, Pham CD, Arthur K, Maxwell D, Peng Z, Leonard PG, Czako B, Pisaneschi F, Mandal P, Sun Y, Zielinski R, Pando SC, Wang X, Tran T, Xu Q, Wu Q, Jiang Y, Kang Z, Asara JM, Priebe W, Bornmann W, Marszalek JR, DePinho RA, Muller FL
Nature metabolism 2020 Dec;2(12):1413-1426

Targeting G6PD reverses paclitaxel resistance in ovarian cancer by suppressing GSTP1.

Feng Q, Li X, Sun W, Sun M, Li Z, Sheng H, Xie F, Zhang S, Shan C
Biochemical pharmacology 2020 Aug;178:114092

The Long Noncoding RNA Lncenc1 Maintains Naive States of Mouse ESCs by Promoting the Glycolysis Pathway.

Sun Z, Zhu M, Lv P, Cheng L, Wang Q, Tian P, Yan Z, Wen B
Stem cell reports 2018 Sep 11;11(3):741-755

Silica-based solid-phase extraction of cross-linked nucleic acid-bound proteins.

Asencio C, Chatterjee A, Hentze MW
Life science alliance 2018 Jun;1(3):e201800088

The Shape of Vesicle-Containing Organelles Is Critical for Their Functions in Vesicle Endocytosis.

Winters CM, Hong-Brown LQ, Chiang HL
DNA and cell biology 2017 Nov;36(11):909-921

CUE domain-containing protein 2 promotes the Warburg effect and tumorigenesis.

Zhong X, Tian S, Zhang X, Diao X, Dong F, Yang J, Li Z, Sun L, Wang L, He X, Wu G, Hu X, Wang L, Song L, Zhang H, Pan X, Li A, Gao P
EMBO reports 2017 May;18(5):809-825

Fatty acid synthesis is critical for stem cell pluripotency via promoting mitochondrial fission.

Wang L, Zhang T, Wang L, Cai Y, Zhong X, He X, Hu L, Tian S, Wu M, Hui L, Zhang H, Gao P
The EMBO journal 2017 May 15;36(10):1330-1347

Proteomic analysis indicates that mitochondrial energy metabolism in skeletal muscle tissue is negatively correlated with feed efficiency in pigs.

Fu L, Xu Y, Hou Y, Qi X, Zhou L, Liu H, Luan Y, Jing L, Miao Y, Zhao S, Liu H, Li X
Scientific reports 2017 Mar 27;7:45291

SF2312 is a natural phosphonate inhibitor of enolase.

Leonard PG, Satani N, Maxwell D, Lin YH, Hammoudi N, Peng Z, Pisaneschi F, Link TM, Lee GR 4th, Sun D, Prasad BAB, Di Francesco ME, Czako B, Asara JM, Wang YA, Bornmann W, DePinho RA, Muller FL
Nature chemical biology 2016 Dec;12(12):1053-1058

cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions.

Sun L, Song L, Wan Q, Wu G, Li X, Wang Y, Wang J, Liu Z, Zhong X, He X, Shen S, Pan X, Li A, Wang Y, Gao P, Tang H, Zhang H
Cell research 2015 Apr;25(4):429-44

Lin28/let-7 axis regulates aerobic glycolysis and cancer progression via PDK1.

Ma X, Li C, Sun L, Huang D, Li T, He X, Wu G, Yang Z, Zhong X, Song L, Gao P, Zhang H
Nature communications 2014 Oct 10;5:5212

Glucose induces rapid changes in the secretome of Saccharomyces cerevisiae.

Giardina BJ, Stanley BA, Chiang HL
Proteome science 2014 Feb 12;12(1):9

Male mice express spermatogenic cell-specific triosephosphate isomerase isozymes.

Ijiri TW, Vadnais ML, Lin AM, Huang AP, Cao W, Merdiushev T, Gerton GL
Molecular reproduction and development 2013 Oct;80(10):862-70

A mutation in Drosophila Aldolase causes temperature-sensitive paralysis, shortened lifespan, and neurodegeneration.

Miller D, Hannon C, Ganetzky B
Journal of neurogenetics 2012 Sep;26(3-4):317-27

A novel Drosophila SOD2 mutant demonstrates a role for mitochondrial ROS in neurodevelopment and disease.

Celotto AM, Liu Z, Vandemark AP, Palladino MJ
Brain and behavior 2012 Jul;2(4):424-34

Identification and validation of mouse sperm proteins correlated with epididymal maturation.

Ijiri TW, Merdiushev T, Cao W, Gerton GL
Proteomics 2011 Oct;11(20):4047-62

Protein expression profiling in the spectrum of renal cell carcinomas.

Valera VA, Li-Ning-T E, Walter BA, Roberts DD, Linehan WM, Merino MJ
Journal of Cancer 2010 Oct 14;1:184-96

The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha.

Zhong L, D'Urso A, Toiber D, Sebastian C, Henry RE, Vadysirisack DD, Guimaraes A, Marinelli B, Wikstrom JD, Nir T, Clish CB, Vaitheesvaran B, Iliopoulos O, Kurland I, Dor Y, Weissleder R, Shirihai OS, Ellisen LW, Espinosa JM, Mostoslavsky R
Cell 2010 Jan 22;140(2):280-93

Amyloid-dependent triosephosphate isomerase nitrotyrosination induces glycation and tau fibrillation.

Guix FX, Ill-Raga G, Bravo R, Nakaya T, de Fabritiis G, Coma M, Miscione GP, Villà-Freixa J, Suzuki T, Fernàndez-Busquets X, Valverde MA, de Strooper B, Muñoz FJ
Brain : a journal of neurology 2009 May;132(Pt 5):1335-45

Degradation of functional triose phosphate isomerase protein underlies sugarkill pathology.

Seigle JL, Celotto AM, Palladino MJ
Genetics 2008 Jun;179(2):855-62

Proteomics in free-living Mus spretus to monitor terrestrial ecosystems.

Montes-Nieto R, Fuentes-Almagro CA, Bonilla-Valverde D, Prieto-Alamo MJ, Jurado J, Carrascal M, Gómez-Ariza JL, López-Barea J, Pueyo C
Proteomics 2007 Dec;7(23):4376-87

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HepG2 cells were subjected to SDS PAGE followed by western blot with 10713-1-AP(TPI1 antibody) at dilution of 1:2000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The TPI1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human TPI1. This antibody recognizes human,mouse,rat antigen. The TPI1 antibody has been validated for the following applications: ELISA, WB, IP analysis.
Appendix: 10713-1-AP.pdf

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