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- Antibody Data
- Antigen structure
- References [5]
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- Product number
- ABIN351311 - Provider product page
- Provider
- antibodies-online
- Proper citation
- Antibodies-Online Cat#ABIN351311, RRID:AB_10805039
- Product name
- anti-Tumor Susceptibility Gene 101 (TSG101) (Internal Region) antibody
- Antibody type
- Polyclonal
- Antigen
- A synthetic peptide from the internal part of rat TSG101 (Tumor susceptibility gene 101 protein) conjugated to an immunogenic carrier protein was used as the immunogen.
- Reactivity
- Human, Mouse, Rat
- Host
- Sheep
- Epitope
- Internal Region
- Isotype
- IgG
- Vial size
- 500 μg
- Storage
- Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability.
- Handling
- Avoid freeze and thaw cycles.
Submitted references TSG101 interacts with apoptosis-antagonizing transcription factor and enhances androgen receptor-mediated transcription by promoting its monoubiquitination.
TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation.
DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci.
Aberrant splicing of the TSG101 and FHIT genes occurs frequently in multiple malignancies and in normal tissues and mimics alterations previously described in tumours.
The TSG101 tumor susceptibility gene is located in chromosome 11 band p15 and is mutated in human breast cancer.
Burgdorf S, Leister P, Scheidtmann KH
The Journal of biological chemistry 2004 Apr 23;279(17):17524-34
The Journal of biological chemistry 2004 Apr 23;279(17):17524-34
TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation.
Lu Q, Hope LW, Brasch M, Reinhard C, Cohen SN
Proceedings of the National Academy of Sciences of the United States of America 2003 Jun 24;100(13):7626-31
Proceedings of the National Academy of Sciences of the United States of America 2003 Jun 24;100(13):7626-31
DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci.
Rountree MR, Bachman KE, Baylin SB
Nature genetics 2000 Jul;25(3):269-77
Nature genetics 2000 Jul;25(3):269-77
Aberrant splicing of the TSG101 and FHIT genes occurs frequently in multiple malignancies and in normal tissues and mimics alterations previously described in tumours.
Gayther SA, Barski P, Batley SJ, Li L, de Foy KA, Cohen SN, Ponder BA, Caldas C
Oncogene 1997 Oct 23;15(17):2119-26
Oncogene 1997 Oct 23;15(17):2119-26
The TSG101 tumor susceptibility gene is located in chromosome 11 band p15 and is mutated in human breast cancer.
Li L, Li X, Francke U, Cohen SN
Cell 1997 Jan 10;88(1):143-54
Cell 1997 Jan 10;88(1):143-54
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