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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [3]
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- Product number
- ABIN356744 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Neural Precursor Cell Expressed, Developmentally Down-Regulated 8 (NEDD8) (N-Term) antibody
- Antibody type
- Polyclonal
- Description
- Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
- Reactivity
- Human
- Host
- Rabbit
- Epitope
- N-Term
- Vial size
- 0.4 mL
- Storage
- Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.
- Handling
- Avoid repeated freezing and thawing.
Submitted references The NEDD8 pathway is required for proteasome-mediated degradation of human estrogen receptor (ER)-alpha and essential for the antiproliferative activity of ICI 182,780 in ERalpha-positive breast cancer cells.
Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer.
DEN1 is a dual function protease capable of processing the C terminus of Nedd8 and deconjugating hyper-neddylated CUL1.
Fan M, Bigsby RM, Nephew KP
Molecular endocrinology (Baltimore, Md.) 2003 Mar;17(3):356-65
Molecular endocrinology (Baltimore, Md.) 2003 Mar;17(3):356-65
Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer.
Bohnsack RN, Haas AL
The Journal of biological chemistry 2003 Jul 18;278(29):26823-30
The Journal of biological chemistry 2003 Jul 18;278(29):26823-30
DEN1 is a dual function protease capable of processing the C terminus of Nedd8 and deconjugating hyper-neddylated CUL1.
Wu K, Yamoah K, Dolios G, Gan-Erdene T, Tan P, Chen A, Lee CG, Wei N, Wilkinson KD, Wang R, Pan ZQ
The Journal of biological chemistry 2003 Aug 1;278(31):28882-91
The Journal of biological chemistry 2003 Aug 1;278(31):28882-91
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