Antibody data

Product number
10-7006 - Provider product page
Provider
ABEOMICS Inc.
Product name
Anti-MBD2/MBD3 Antibody
Antibody type
Monoclonal
Description
MBD2 is a subunit of the NuRD complex that is postulated to mediate gene repression via recruitment of the complex to methylated DNA. This protein binds around 1 kb downstream of the transcription start site of a subset of  400 CpG island promoters that are characterized by the presence of active histone marks, RNA polymerase II (Pol2) and low to medium gene expression levels and H3K36me3 deposition. Methylated MBD2 is involved in silencing methylated tumor suppressor genes as well as activation of pro-metastatic genes. MBD2 also plays a key role in regulating expression of a range of genes that are associated with optimal DC (Dendritic cells) activation and function.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Antigen sequence
A partial length recombinant MBD3 p
rotein (amino acids 1-290) was used
as the immunogen for this antibody
.
Isotype
IgG
Antibody clone number
ABM14A8
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freez thawing
MBD3 protein structure - 10-7006 shown in red.