Antibody data

Product number
BS2132 - Provider product page
Provider
Bioworld Technology, Inc
Proper citation
Bioworld Technology Cat#BS2132, RRID:AB_1662349
Product name
TIN2 (V94) polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic peptide, corresponding to amino acids 60-110 of Human TIN2.
Description
Mammalian telomeric proteins consist of TRF1 (telomeric repeat binding factor), TRF2, tankyrase, and TIN2, which have no recognized orthologs in the budding yeast, Saccharomyces cerevisiae, and RAP1, which is an ortholog to the yeast telomeric protein scRap1. Like scRap1, mammalian RAP1 regulates telomere elongation. RAP1 interacts with two proteins, Rif1 and Rif2, which contribute to telomere length homeostasis. Unlike scRap1, which binds telomeric DNA directly, RAP1 is recruited to telomeres by TRF2. The functional and structural similarities of scRap1 to mammalian RAP1 suggest that the budding yeast preserved RAP1 at telomeres, but lost the TRF component. The telomeric protein TRF1 requires TIN2 to control telomere length in human cells.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
TINF2 protein structure - BS2132 shown in red.