Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- BS2132 - Provider product page
- Provider
- Bioworld Technology, Inc
- Proper citation
- Bioworld Technology Cat#BS2132, RRID:AB_1662349
- Product name
- TIN2 (V94) polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide, corresponding to amino acids 60-110 of Human TIN2.
- Description
- Mammalian telomeric proteins consist of TRF1 (telomeric repeat binding factor), TRF2, tankyrase, and TIN2, which have no recognized orthologs in the budding yeast, Saccharomyces cerevisiae, and RAP1, which is an ortholog to the yeast telomeric protein scRap1. Like scRap1, mammalian RAP1 regulates telomere elongation. RAP1 interacts with two proteins, Rif1 and Rif2, which contribute to telomere length homeostasis. Unlike scRap1, which binds telomeric DNA directly, RAP1 is recruited to telomeres by TRF2. The functional and structural similarities of scRap1 to mammalian RAP1 suggest that the budding yeast preserved RAP1 at telomeres, but lost the TRF component. The telomeric protein TRF1 requires TIN2 to control telomere length in human cells.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
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- Experimental details
- Western blot (WB) analysis of TIN2 (V94) pAb at 1:500 dilutionLane1:HEK293T whole cell lysateLane2:Raw264.7 whole cell lysateLane3:H9C2 whole cell lysate