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ImmunocytochemistryAntibody data
- Antibody Data
- Antigen structure
- References [12]
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- Validations
- Western blot [2]
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- Product number
- NB600-1522 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NB600-1522, RRID:AB_2205096
- Product name
- Mouse Monoclonal TIN2 Antibody
- Antibody type
- Monoclonal
- Description
- Protein G purified.
- Reactivity
- Human, Mouse
- Host
- Mouse
- Isotype
- IgG
- Vial size
- 0.1 mg
- Concentration
- 1.0 mg/ml
- Storage
- Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Submitted references The Shelterin TIN2 Subunit Mediates Recruitment of Telomerase to Telomeres.
DNA damage accumulation and TRF2 degradation in atypical Werner syndrome fibroblasts with LMNA mutations.
Telomere dysfunction and activation of alternative lengthening of telomeres in B-lymphocytes infected by Epstein-Barr virus.
Characterization of the DNA binding specificity of Shelterin complexes.
The Epstein-Barr virus nuclear antigen-1 promotes telomere dysfunction via induction of oxidative stress.
Spontaneous occurrence of telomeric DNA damage response in the absence of chromosome fusions.
Identification of candidate alternative lengthening of telomeres genes by methionine restriction and RNA interference.
Human fetal ovarian culture permits meiotic progression and chromosome pairing process.
Chromosome 18 pairing behavior in human trisomic oocytes. Presence of an extra chromosome extends bouquet stage.
A dynamic molecular link between the telomere length regulator TRF1 and the chromosome end protector TRF2.
TIN2 mediates functions of TRF2 at human telomeres.
Female-specific features of recombinational double-stranded DNA repair in relation to synapsis and telomere dynamics in human oocytes.
Frank AK, Tran DC, Qu RW, Stohr BA, Segal DJ, Xu L
PLoS genetics 2015 Jul;11(7):e1005410
PLoS genetics 2015 Jul;11(7):e1005410
DNA damage accumulation and TRF2 degradation in atypical Werner syndrome fibroblasts with LMNA mutations.
Saha B, Zitnik G, Johnson S, Nguyen Q, Risques RA, Martin GM, Oshima J
Frontiers in genetics 2013;4:129
Frontiers in genetics 2013;4:129
Telomere dysfunction and activation of alternative lengthening of telomeres in B-lymphocytes infected by Epstein-Barr virus.
Kamranvar SA, Chen X, Masucci MG
Oncogene 2013 Dec 5;32(49):5522-30
Oncogene 2013 Dec 5;32(49):5522-30
Characterization of the DNA binding specificity of Shelterin complexes.
Choi KH, Farrell AS, Lakamp AS, Ouellette MM
Nucleic acids research 2011 Nov;39(21):9206-23
Nucleic acids research 2011 Nov;39(21):9206-23
The Epstein-Barr virus nuclear antigen-1 promotes telomere dysfunction via induction of oxidative stress.
Kamranvar SA, Masucci MG
Leukemia 2011 Jun;25(6):1017-25
Leukemia 2011 Jun;25(6):1017-25
Spontaneous occurrence of telomeric DNA damage response in the absence of chromosome fusions.
Cesare AJ, Kaul Z, Cohen SB, Napier CE, Pickett HA, Neumann AA, Reddel RR
Nature structural & molecular biology 2009 Dec;16(12):1244-51
Nature structural & molecular biology 2009 Dec;16(12):1244-51
Identification of candidate alternative lengthening of telomeres genes by methionine restriction and RNA interference.
Jiang WQ, Zhong ZH, Henson JD, Reddel RR
Oncogene 2007 Jul 12;26(32):4635-47
Oncogene 2007 Jul 12;26(32):4635-47
Human fetal ovarian culture permits meiotic progression and chromosome pairing process.
Roig I, Garcia R, Robles P, Cortvrindt R, Egozcue J, Smitz J, Garcia M
Human reproduction (Oxford, England) 2006 Jun;21(6):1359-67
Human reproduction (Oxford, England) 2006 Jun;21(6):1359-67
Chromosome 18 pairing behavior in human trisomic oocytes. Presence of an extra chromosome extends bouquet stage.
Roig I, Robles P, Garcia R, MartÃnez-Flores I, Cabero L, Egozcue J, Liebe B, Scherthan H, Garcia M
Reproduction (Cambridge, England) 2005 May;129(5):565-75
Reproduction (Cambridge, England) 2005 May;129(5):565-75
A dynamic molecular link between the telomere length regulator TRF1 and the chromosome end protector TRF2.
Houghtaling BR, Cuttonaro L, Chang W, Smith S
Current biology : CB 2004 Sep 21;14(18):1621-31
Current biology : CB 2004 Sep 21;14(18):1621-31
TIN2 mediates functions of TRF2 at human telomeres.
Kim SH, Beausejour C, Davalos AR, Kaminker P, Heo SJ, Campisi J
The Journal of biological chemistry 2004 Oct 15;279(42):43799-804
The Journal of biological chemistry 2004 Oct 15;279(42):43799-804
Female-specific features of recombinational double-stranded DNA repair in relation to synapsis and telomere dynamics in human oocytes.
Roig I, Liebe B, Egozcue J, Cabero L, Garcia M, Scherthan H
Chromosoma 2004 Aug;113(1):22-33
Chromosoma 2004 Aug;113(1):22-33
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: TIN2 Antibody (59B388.1) [NB600-1522] - Analysis of Tin2 using Tin2 monoclonal antibody 59B388.1. Human Daudi (A) and mouse NIH 3T3 lysate probed using Tin2 antibody at 2 ug/ml.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: TIN2 Antibody (59B388.1) [NB600-1522] - CD4+ T-cells were isolated from HS PBMCs after 2 days incubation with or without 5 uM KML001. Image from verified customer review.
