13483-1-AP

antibody from Proteintech Group

Targeting: TREM2 TREM-2, Trem2a, Trem2b, Trem2c

ELISA (Data presented on provider website)

Antibody Data

Product number

13483-1-AP

Provider

Proteintech Group

Product name

TREM2 antibody

Antibody type

Polyclonal

Description

TREM2 antibody (Cat. #13483-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: ELISA.

Reactivity

Human, Mouse

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Protective role for kidney TREM2(high) macrophages in obesity- and diabetes-induced kidney injury.

Subramanian A, Vernon KA, Zhou Y, Marshall JL, Alimova M, Arevalo C, Zhang F, Slyper M, Waldman J, Montesinos MS, Dionne D, Nguyen LT, Cuoco MS, Dubinsky D, Purnell J, Keller K, Sturner SH, Grinkevich E, Ghoshal A, Kotek A, Trivioli G, Richoz N, Humphrey MB, Darby IG, Miller SJ, Xu Y, Weins A, Chloe-Villani A, Chang SL, Kretzler M, Rosenblatt-Rosen O, Shaw JL, Zimmerman KA, Clatworthy MR, Regev A, Greka A
Cell reports 2024 Jun 25;43(6):114253

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TREM2 as an independent predictor of poor prognosis promotes the migration via the PI3K/AKT axis in prostate cancer.

Gao HT, Yang Z, Sun H, Zhang Y, Wang Z, Liu WY, Wen HZ, Qu CB, Wang XL
American journal of translational research 2023;15(2):779-798

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An integrated gene-to-outcome multimodal database for metabolic dysfunction-associated steatotic liver disease.

Kendall TJ, Jimenez-Ramos M, Turner F, Ramachandran P, Minnier J, McColgan MD, Alam M, Ellis H, Dunbar DR, Kohnen G, Konanahalli P, Oien KA, Bandiera L, Menolascina F, Juncker-Jensen A, Alexander D, Mayor C, Guha IN, Fallowfield JA
Nature medicine 2023 Nov;29(11):2939-2953

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Inflammasome activation under high cholesterol load triggers a protective microglial phenotype while promoting neuronal pyroptosis.

de Dios C, Abadin X, Roca-Agujetas V, Jimenez-Martinez M, Morales A, Trullas R, Mari M, Colell A
Translational neurodegeneration 2023 Mar 9;12(1):10

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An integrated single cell and spatial transcriptomic map of human white adipose tissue.

Massier L, Jalkanen J, Elmastas M, Zhong J, Wang T, Nono Nankam PA, Frendo-Cumbo S, Bäckdahl J, Subramanian N, Sekine T, Kerr AG, Tseng BTP, Laurencikiene J, Buggert M, Lourda M, Kublickiene K, Bhalla N, Andersson A, Valsesia A, Astrup A, Blaak EE, Ståhl PL, Viguerie N, Langin D, Wolfrum C, Blüher M, Rydén M, Mejhert N
Nature communications 2023 Mar 15;14(1):1438

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Blockade of IL-6 signaling alleviates atherosclerosis in Tet2-deficient clonal hematopoiesis.

Liu W, Yalcinkaya M, Maestre IF, Olszewska M, Ampomah PB, Heimlich JB, Wang R, Vela PS, Xiao T, Bick AG, Levine R, Papapetrou EP, Libby P, Tabas I, Wang N, Tall AR
Nature cardiovascular research 2023 Jun;2(6):572-586

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Cystatin C is glucocorticoid responsive, directs recruitment of Trem2+ macrophages, and predicts failure of cancer immunotherapy.

Kleeman SO, Thakir TM, Demestichas B, Mourikis N, Loiero D, Ferrer M, Bankier S, Riazat-Kesh YJRA, Lee H, Chantzichristos D, Regan C, Preall J, Sinha S, Rosin N, Yipp B, de Almeida LGN, Biernaskie J, Dufour A, Tober-Lau P, Ruusalepp A, Bjorkegren JLM, Ralser M, Kurth F, Demichev V, Heywood T, Gao Q, Johannsson G, Koelzer VH, Walker BR, Meyer HV, Janowitz T
Cell genomics 2023 Aug 9;3(8):100347

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Effects of electroacupuncture on DNA methylation of the TREM2 gene in senescence-accelerated mouse prone 8 mice.

Jiang J, Liu H, Wang Z, Tian H, Wang S, Yang J, Li Z
Acupuncture in medicine : journal of the British Medical Acupuncture Society 2022 Oct;40(5):463-469

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Activation of TREM2 attenuates neuroinflammation via PI3K/Akt signaling pathway to improve postoperative cognitive dysfunction in mice.

Han X, Cheng X, Xu J, Liu Y, Zhou J, Jiang L, Gu X, Xia T
Neuropharmacology 2022 Nov 15;219:109231

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TREM2 ameliorates anesthesia and surgery-induced cognitive impairment by regulating mitophagy and NLRP3 inflammasome in aged C57/BL6 mice.

Jiang W, Liu F, Li H, Wang K, Cao X, Xu X, Zhou Y, Zou J, Zhang X, Cui X
Neurotoxicology 2022 May;90:216-227

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TREM2 and CD163 Ameliorate Microglia-Mediated Inflammatory Environment in the Aging Brain.

Han X, Liu YJ, Liu BW, Ma ZL, Xia TJ, Gu XP
Journal of molecular neuroscience : MN 2022 May;72(5):1075-1084

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Methamphetamine-mediated dissemination of β-amyloid: Disturbances in endocytosis, transport and clearance of β-amyloid in microglial BV2 cells.

Tao L, Hu M, Zhang X, Wang X, Zhang Y, Chen X, Tang J, Wang J
Toxicology and applied pharmacology 2022 Jul 15;447:116090

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Edaravone ameliorates depressive and anxiety-like behaviors via Sirt1/Nrf2/HO-1/Gpx4 pathway.

Dang R, Wang M, Li X, Wang H, Liu L, Wu Q, Zhao J, Ji P, Zhong L, Licinio J, Xie P
Journal of neuroinflammation 2022 Feb 7;19(1):41

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The Microglial membrane receptor TREM2 mediates exosome secretion to promote phagocytosis of amyloid-β by microglia.

Huang S, Liao X, Wu J, Zhang X, Li Y, Xiang D, Luo S
FEBS letters 2022 Apr;596(8):1059-1071

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Harpagide alleviate neuronal apoptosis and blood-brain barrier leakage by inhibiting TLR4/MyD88/NF-κB signaling pathway in Angiotensin II-induced microglial activation in vitro.

Lu Y, Hao R, Hu Y, Wei Y, Xie Y, Shen Y, Rui Q, Yu G
Chemico-biological interactions 2021 Oct 1;348:109653

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Sexually Dimorphic Relationships Among Saa3 (Serum Amyloid A3), Inflammation, and Cholesterol Metabolism Modulate Atherosclerosis in Mice.

Chait A, Wang S, Goodspeed L, Gomes D, Turk KE, Wietecha T, Tang J, Storey C, O'Brien KD, Rubinow KB, Tang C, Vaisar T, Gharib SA, Lusis AJ, Den Hartigh LJ
Arteriosclerosis, thrombosis, and vascular biology 2021 Jun;41(6):e299-e313

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Single-cell RNA-seq reveals cellular heterogeneity of mouse carotid artery under disturbed flow.

Li F, Yan K, Wu L, Zheng Z, Du Y, Liu Z, Zhao L, Li W, Sheng Y, Ren L, Tang C, Zhu L
Cell death discovery 2021 Jul 16;7(1):180

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Microglia TREM2: A Potential Role in the Mechanism of Action of Electroacupuncture in an Alzheimer's Disease Animal Model.

Li Y, Jiang J, Tang Q, Tian H, Wang S, Wang Z, Liu H, Yang J, Ren J
Neural plasticity 2020;2020:8867547

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Single-Cell Transcriptome Analysis Reveals Intratumoral Heterogeneity in ccRCC, which Results in Different Clinical Outcomes.

Hu J, Chen Z, Bao L, Zhou L, Hou Y, Liu L, Xiong M, Zhang Y, Wang B, Tao Z, Chen K
Molecular therapy : the journal of the American Society of Gene Therapy 2020 Jul 8;28(7):1658-1672