27599-1-AP

antibody from Proteintech Group

Targeting: TREM2 TREM-2, Trem2a, Trem2b, Trem2c

Provider product page for 27599-1-AP

ELISA

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [21]
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Product number: 27599-1-AP - Provider product page
Provider: Proteintech Group
Product name: TREM2 antibody
Antibody type: Polyclonal
Description: TREM2 antibody (Cat. #27599-1-AP) is a rabbit polyclonal antibody that shows reactivity with Human and has been validated for the following applications: IHC,ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

TREM2 protein structure - 27599-1-AP shown in red.

Submitted references Increased ocular plasma cells induce damaging α-synuclein(+) microglia in autoimmune uveitis.

Li M, Feng M, Liu T, Duan S, Man X, Yuan X, Wang L, Sun Y, Wei X, Fu Q, Sun B, Lin W
Mucosal immunology 2025 Jun;18(3):668-684

PEGylated Nanoliposomal Doxorubicin Conjugated with Specific TREM2 Peptides for Glioma-Targeting Therapy.

Li H, Xu D, Cai W, Liu J, Bing Z, Zhang Q
Advanced healthcare materials 2025 Feb;14(4):e2403096

MicroRNA-3473b regulates corticosterone-induced microglial polarization and inflammation through TREM2.

Shi J, Ma C, Liu Y, Yang C, Wu J, Wang X
Journal of pharmacological sciences 2025 Dec;159(4):209-218

Uric Acid Functions as an Endogenous Modulator of Microglial Function and Amyloid Clearance in Alzheimer's Disease.

Xie D, Zheng Q, Lv J, Zhang Q, Cui Z, Huang S, Yu W, Chen B, Que W, Fu S, Xi Y, Chen J, Ye X, Chen S, Zhao H, Yamamoto T, Koyama H, Wang X, Cheng J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(48):e10270

COG1410 Alleviated Chronic Sleep Deprivation-Induced Memory Loss by Regulating Microglial Phagocytosis and Inhibiting Hippocampal Inflammation.

Wu P, Fu C, Chen M, Wu F, He W, Luo Q, Wang H, Li Y
ACS chemical neuroscience 2025 Aug 6;16(15):2921-2934

HMOX1-LDHB interaction promotes ferroptosis by inducing mitochondrial dysfunction in foamy macrophages during advanced atherosclerosis.

Peng X, Sun B, Tang C, Shi C, Xie X, Wang X, Jiang D, Li S, Jia Y, Wang Y, Tang H, Zhong S, Piao M, Cui X, Zhang S, Wang F, Wang Y, Na R, Huang R, Jiang Y, Zhang W, Xu J, Lin K, Guo J, Pan Z, Wang K, Zhao Q, Liu H, Yu B, Ji Y, Zhang J, Li S, Tian J
Developmental cell 2025 Apr 7;60(7):1070-1086.e8

Perioperative enriched environment attenuates postoperative cognitive dysfunction by upregulating microglia TREM2 via PI3K/Akt pathway in mouse model of ischemic stroke.

Yao Y, Hu L, Li D, Wang Y, Pan J, Fan D
Frontiers in neuroscience 2024;18:1520710

Maresin1 restrains chronic inflammation and Aβ production to ameliorate Alzheimer's disease via modulating ADAM10/17 and its associated neuroprotective signal pathways: A pilot study.

Sun S, Zhang T, Liu L, Zhou H, Yin P, Wang L
Archives of biochemistry and biophysics 2024 Sep;759:110109

Inhibition of hepatic oxalate overproduction ameliorates metabolic dysfunction-associated steatohepatitis.

Das S, Finney AC, Anand SK, Rohilla S, Liu Y, Pandey N, Ghrayeb A, Kumar D, Nunez K, Liu Z, Arias F, Zhao Y, Pearson-Gallion BH, McKinney MP, Richard KSE, Gomez-Vidal JA, Abdullah CS, Cockerham ED, Eniafe J, Yurochko AD, Magdy T, Pattillo CB, Kevil CG, Razani B, Bhuiyan MS, Seeley EH, Galliano GE, Wei B, Tan L, Mahmud I, Surakka I, Garcia-Barrio MT, Lorenzi PL, Gottlieb E, Salido E, Zhang J, Orr AW, Liu W, Diaz-Gavilan M, Chen YE, Dhanesha N, Thevenot PT, Cohen AJ, Yurdagul A Jr, Rom O
Nature metabolism 2024 Oct;6(10):1939-1962

Inflammatory crosstalk impairs phagocytic receptors and aggravates atherosclerosis in clonal hematopoiesis in mice.

Liu W, Hardaway BD, Kim E, Pauli J, Wettich JL, Yalcinkaya M, Hsu CC, Xiao T, Reilly MP, Tabas I, Maegdefessel L, Schlepckow K, Haass C, Wang N, Tall AR
The Journal of clinical investigation 2024 Nov 12;135(1)

TREM2 deficiency impairs the energy metabolism of Schwann cells and exacerbates peripheral neurological deficits.

Zhang N, Ji Q, Chen Y, Wen X, Shan F
Cell death & disease 2024 Mar 7;15(3):193

TREM2 deficiency aggravates renal injury by promoting macrophage apoptosis and polarization via the JAK-STAT pathway in mice.

Cui Y, Chen C, Tang Z, Yuan W, Yue K, Cui P, Qiu X, Zhang H, Li T, Zhu X, Luo J, Sun S, Li Y, Feng C, Peng L, Xie X, Guo Y, Xie Y, Jiang X, Qi Z, Thomson AW, Dai H
Cell death & disease 2024 Jun 7;15(6):401

HMGB1/TREM2 positive feedback loop drives the development of radioresistance and immune escape of glioblastoma by regulating TLR4/Akt signaling.

Qiu H, Shao Z, Wen X, Qu D, Liu Z, Chen Z, Zhang X, Ding X, Zhang L
Journal of translational medicine 2024 Jul 29;22(1):688

Dysregulated expression of miR-140 and miR-122 compromised microglial chemotaxis and led to reduced restriction of AD pathology.

Song C, Li S, Mai Y, Li L, Dai G, Zhou Y, Liang X, Zou OM, Wang Y, Zhou L, Liu J, Zou Y
Journal of neuroinflammation 2024 Jul 2;21(1):167

TREM2 regulates BV2 microglia activation and influences corticosterone-induced neuroinflammation in depressive disorders.

Shi J, Wang X, Kang C, Liu J, Ma C, Yang L, Hu J, Zhao N
Brain research 2024 Jan 1;1822:148664

A single cell atlas of frozen shoulder capsule identifies features associated with inflammatory fibrosis resolution.

Ng MTH, Borst R, Gacaferi H, Davidson S, Ackerman JE, Johnson PA, Machado CC, Reekie I, Attar M, Windell D, Kurowska-Stolarska M, MacDonald L, Alivernini S, Garvilles M, Jansen K, Bhalla A, Lee A, Charlesworth J, Chowdhury R, Klenerman P, Powell K, Hackstein CP, ICECAP Consortium, Furniss D, Rees J, Gilroy D, Coles M, Carr AJ, Sansom SN, Buckley CD, Dakin SG
Nature communications 2024 Feb 19;15(1):1394

Osmundacetone ameliorates Alzheimer's-like pathologies by inhibiting β-amyloid fibrillation, oxidative damage and neuroinflammation in APP/PS1 transgenic mice.

Zhao LX, Ren H, Su JY, Zhang Q, He DL, Wu TY, Zhang YH, Wang ZY, Fan YG
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156091

Identification of TREM2-positive tumor-associated macrophages in esophageal squamous cell carcinoma: implication for poor prognosis and immunotherapy modulation.

Li H, Miao Y, Zhong L, Feng S, Xu Y, Tang L, Wu C, Zhang X, Gu L, Diao H, Wang H, Wen Z, Yang M
Frontiers in immunology 2023;14:1162032

Soluble TREM2 ameliorates tau phosphorylation and cognitive deficits through activating transgelin-2 in Alzheimer's disease.

Zhang X, Tang L, Yang J, Meng L, Chen J, Zhou L, Wang J, Xiong M, Zhang Z
Nature communications 2023 Oct 21;14(1):6670

TREM2 inhibition triggers antitumor cell activity of myeloid cells in glioblastoma.

Sun R, Han R, McCornack C, Khan S, Tabor GT, Chen Y, Hou J, Jiang H, Schoch KM, Mao DD, Cleary R, Yang A, Liu Q, Luo J, Petti A, Miller TM, Ulrich JD, Holtzman DM, Kim AH
Science advances 2023 May 12;9(19):eade3559

Heterogeneity of tumor microenvironment is associated with clinical prognosis of non-clear cell renal cell carcinoma: a single-cell genomics study.

Chen WJ, Cao H, Cao JW, Zuo L, Qu FJ, Xu D, Zhang H, Gong HY, Chen JX, Ye JQ, Gan SS, Zhou W, Zhu DW, Pan XW, Cui XG
Cell death & disease 2022 Jan 11;13(1):50

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