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Flow cytometryAntibody data
- Antibody Data
- Antigen structure
- References [3]
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- Validations
- Flow cytometry [3]
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- Product number
- FAB17291A - Provider product page
- Provider
- R&D Systems
- Product name
- Human/Mouse TREM2 APC-conjugated Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from hybridoma culture supernatant. Detects human and mouse TREM-2 in direct ELISAs and Western blots. Stains TREM-2 transfectants but not TREM-1 transfectants.
- Reactivity
- Human, Mouse
- Host
- Rat
- Conjugate
- Red dye
- Antigen sequence
Q99NH8- Isotype
- IgG
- Antibody clone number
- 237920
- Vial size
- 100 Tests
- Storage
- Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied.
Submitted references TREM2-activating antibodies abrogate the negative pleiotropic effects of the Alzheimer's disease variant Trem2R47H on murine myeloid cell function.
Increased TREM-2 expression on the subsets of CD11c+ cells in the lungs and lymph nodes during allergic airway inflammation.
CD33 modulates TREM2: convergence of Alzheimer loci.
Cheng Q, Danao J, Talreja S, Wen P, Yin J, Sun N, Li CM, Chui D, Tran D, Koirala S, Chen H, Foltz IN, Wang S, Sambashivan S
The Journal of biological chemistry 2018 Aug 10;293(32):12620-12633
The Journal of biological chemistry 2018 Aug 10;293(32):12620-12633
Increased TREM-2 expression on the subsets of CD11c+ cells in the lungs and lymph nodes during allergic airway inflammation.
Hall SC, Agrawal DK
Scientific reports 2017 Sep 19;7(1):11853
Scientific reports 2017 Sep 19;7(1):11853
CD33 modulates TREM2: convergence of Alzheimer loci.
Chan G, White CC, Winn PA, Cimpean M, Replogle JM, Glick LR, Cuerdon NE, Ryan KJ, Johnson KA, Schneider JA, Bennett DA, Chibnik LB, Sperling RA, Bradshaw EM, De Jager PL
Nature neuroscience 2015 Nov;18(11):1556-8
Nature neuroscience 2015 Nov;18(11):1556-8
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Supportive validation
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- Detection of TREM-2 in HEK Human Cell Line Transfected with Human TREM-2 and eGFP by Flow Cytometry. HEK293 human embryonic kidney cell line transfected with either (A) human TREM-2 or (B) human TREM-1 and eGFP was stained with Rat Anti-Human/Mouse TREM-2 APC-conjugated Monoclonal Antibody (Catalog # FAB17291A). Quadrant markers were set based on control antibody staining (Catalog # IC013A). View our protocol for Staining Membrane-associated Proteins.
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- Detection of TREM-2 in Human Blood Monocytes by Flow Cytometry. Human peripheral blood monocytes were stained with (A) Rat Anti-Human/Mouse TREM-2 APC-conjugated Monoclonal Antibody (Catalog # FAB17291A) or (B) isotype control antibody (Catalog # IC013A) followed by Mouse anti-Human Integrin alpha M/CD11b PE-conjugated Monoclonal Antibody (Catalog # FAB16991P). View our protocol for Staining Membrane-associated Proteins.
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- Detection of TREM-2 in RAW 264.7 Mouse Cell Line by Flow Cytometry. RAW 264.7 mouse monocyte/macrophage cell line was stained with Rat Anti-Human/Mouse TREM-2 APC-conjugated Monoclonal Antibody (Catalog # FAB17291A, filled histogram) or isotype control antibody (Catalog # IC013A, open histogram). View our protocol for Staining Membrane-associated Proteins.
