Antibody data
- Antibody Data
- Antigen structure
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- Product number
- AMM02427G - Provider product page
- Provider
- Leading Biology
- Product name
- CST3 Antibody
- Antibody type
- Monoclonal
- Description
- The cystatin superfamily encompasses proteins that containmultiple cystatin-like sequences. Some of the members are activecysteine protease inhibitors, while others have lost or perhapsnever acquired this inhibitory activity. There are three inhibitoryfamilies in the superfamily, including the type 1 cystatins(stefins), type 2 cystatins and the kininogens. The type 2 cystatinproteins are a class of cysteine proteinase inhibitors found in avariety of human fluids and secretions, where they appear toprovide protective functions. The cystatin locus on chromosome 20contains the majority of the type 2 cystatin genes and pseudogenes.This gene is located in the cystatin locus and encodes the mostabundant extracellular inhibitor of cysteine proteases, which isfound in high concentrations in biological fluids and is expressedin virtually all organs of the body. A mutation in this gene hasbeen associated with amyloid angiopathy. Expression of this proteinin vascular wall smooth muscle cells is severely reduced in bothatherosclerotic and aneurysmal aortic lesions, establishing itsrole in vascular disease.
- Reactivity
- Human
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- 572CT4.3.2
- Storage
- Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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