26486-1-AP

antibody from Proteintech Group

Targeting: SLC2A9 Glut9, GLUTX, URATv1

Provider product page for 26486-1-AP

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Product number: 26486-1-AP - Provider product page
Provider: Proteintech Group
Product name: SLC2A9 antibody
Antibody type: Polyclonal
Description: SLC2A9 antibody (Cat. #26486-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

SLC2A9 protein structure - 26486-1-AP shown in red.

Submitted references Multi-omics analysis reveals the mechanism of verbenalin in treating gout via modulating purine metabolism, gut microbiota, and inflammatory pathways.

Xiao Y, Zhang T, Chen Q, Zhang Y, Chen B, Wang M, Zhang Y, Huang M, Su Y, Guo J
Frontiers in immunology 2026;17:1761558

Lactiplantibacillus pentosus JWN01 and Lactiplantibacillus plantarum JWN02 attenuate renal fibrosis and pathological autophagy in hyperuricemic nephropathy via gut-kidney axis.

Mo Q, Qin M, Liang H, Wei L, Li Y, Qin Y, Tang L, Liang J, Qian C, Liang Y, Luo S, Wei Y, Kong L, Cheng J
Food research international (Ottawa, Ont.) 2026 Mar 31;228:118376

Huazhuo Sanjie Chubi Decoction attenuates gouty arthritis and kidney fibrosis by regulating urate transporters and JAK2/STAT3 pathway.

Zhong X, Lin S, Zhong M, Zhang Z, Chen X, Guo J, Chen P, Zheng Y, Huang M, Su Y
Journal of ethnopharmacology 2026 Jan 10;354:120457

Febuxostat alleviates gout-associated hyperuricemia and inflammation by downregulating IL1A to modulate TLR2/TLR4/NF-κB signaling pathway.

Hu M, Zhou Y, Zhang Y, Pan F, Liu M
International immunopharmacology 2026 Jan 1;168(Pt 2):115935

Wuling capsule alleviates hyperuricaemia and protects UA- injured HK-2 cells by regulating uric acid transporter proteins.

Li N, Liu H, Song Z, Zhou R, Tang Z, Xu H, Shi X, Liu Y, Ni J
Frontiers in pharmacology 2025;16:1563676

Effect and mechanism of Plantaginis Semen polysaccharides on intestinal microecology in rats with hyperuricemia.

Zhao J, Fu Y, Qiu H
Frontiers in microbiology 2025;16:1555734

Cyclocarya paliurus polysaccharides alleviate hyperuricemia in mice by regulating gut microbiota to enhance uric acid excretion.

Cao Y, Hu W, Yu C, Chen L, Chen H, Lin S, Wang D, Wang W
International journal of biological macromolecules 2025 Sep;322(Pt 4):147029

Moslae Herba extract alleviates hyperuricemia by regulating uric acid metabolism and relieving renal inflammation and fibrosis in mice.

Guo J, Liu H, Jin T, Jia J, Zhu W, Xia X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:156974

Gut-kidney axis modulation by viable and inactivated Akkermansia muciniphila mitigates avian hyperuricemia through microbial-metabolic crosstalk.

Fu Y, Chen J, Cao Q, Zhu S, Chen W, Luo H, Zhao Y, Bernard LA, Wang X, Tu Q, Zhang Y, Jiang X, Yang L, Wang W
mSystems 2025 Sep 23;10(9):e0077325

Urolithin C Ameliorates Hyperuricemia by Mitigating Renal Dysfunction through ROS-p38/ERK MAPK Axis Suppression.

Han Q, Chen N, Peng K, Wang M, Chen M, Mamadalieva NZ, Zhang Y, Liu C, Ren Q
Journal of agricultural and food chemistry 2025 Sep 10;73(36):22485-22501

Secoisolariciresinol diglucoside (SDG) from flaxseed meal alleviates hyperuricemia in mice by regulating uric acid metabolism and intestinal homeostasis.

Wang S, Chen J, Li Y, Wang Y
Food research international (Ottawa, Ont.) 2025 Oct;217:116770

Identifying the natural compounds in Jinqian Xuduan Decoction for simultaneous uric acid lowering and chronic kidney disease amelioration.

Wang H, Zhang J, Wang B, Lei T, Feng J, Liu A, Huang L, Wang X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Oct;146:157109

Molecular interplay between TXNIP and GLUT9 underlies uric acid transport dysregulation in vitro under hyperuricemic stress.

Zhu Y, Zhang B, He Y, Du M, Chen W, Chen X, Yang Q, Kahaer M, Sun Y
European journal of medical research 2025 Oct 9;30(1):942

Modulation of NLRP3 inflammasome and uric acid metabolism by small molecule pectin from Premna ligustroides Hemsl leaves: Implications for hyperuricemia management.

Deng L, He R, Mao J, Yang H, Shi Q, Peng Y, Zhong G
International journal of biological macromolecules 2025 Nov;331(Pt 1):148214

Diacylglycerol from camellia oil improves hyperuricemia by inhibiting xanthine oxidase and modulating gut microbiota.

Chen Y, Xiao J, Zhang L, Mu J, Wang J, Yu X, Li L, Xiao Z, Liang Y
International journal of biological macromolecules 2025 May;309(Pt 2):142451

Terminalia chebula Retz. extract relieves gout arthritis by inhibiting xanthine oxidase, the uric acid transporter, and NLRP3 inflammasome activation.

He A, Wang J, Feng Y, Liao Z, Zheng Q, Zhang W, Chen H
Journal of ethnopharmacology 2025 May 28;348:119848

Punicalagin attenuates hyperuricemia via restoring hyperuricemia-induced renal and intestinal dysfunctions.

Han QQ, Ren QD, Guo X, Farag MA, Zhang YH, Zhang MQ, Chen YY, Sun ST, Sun JY, Li NY, Liu C
Journal of advanced research 2025 Mar;69:449-461

Oleanolic Acid Alleviates Hyperuricemia via Gut Microbiota Control the Integrity of Gut Barrier and the Expressions of Urate Transporter in Mice.

Zhang T, Liu S, Liu S, Zhao P, Zhang C, Wang X, Meng Y, Lu Y
Journal of agricultural and food chemistry 2025 Mar 12;73(10):5899-5914

Adipocyte-secreted ANGPTL2 promotes hyperuricemia through inhibiting AKT/ABCG2 signaling.

Yang L, Yin R, Shan Z, Feng A, Li K, Wang Y, Yu K, Xu Y, Mao L, Lang J, Zhang B, Zhao D
Free radical biology & medicine 2025 Jun;233:209-225

Weizmannia coagulans BC99 alleviates hyperuricemia by restoring liver-kidney-gut axis dysfunction caused by hyperuricemia.

Wu Y, Gao Y, Li C, Zhai S, Dong Y, Tie S, Zhao L, Gu S
Food & function 2025 Jul 28;16(15):6080-6100

The Urate-Lowering Effects and Renal Protective Activity of Iridoid Glycosides from Paederia foetida in Rats with Hyperuricemia-Induced Kidney Injury: A Pharmacological and Molecular Docking Study.

Zhou H, Yue X, Shen L, Wu L, Li X, Wu T
Molecules (Basel, Switzerland) 2025 Jul 24;30(15)

Limosilactobacillus fermentum M5e Attenuates Hyperuricemia and Renal Injury via Dual Modulation of Gut Microbiota and Purine Metabolic Pathways.

He Y, Aikepa D, Liang M, Chen W, Du M, Zhu Y, Yang D, Chen X, Yang Q, Sun Y
ACS pharmacology & translational science 2025 Jul 11;8(7):2117-2131

Anti-hyperuricemic effects of the seeds of Hovenia acerba in hyperuricemia mice.

Wang Y, Liao X, Zhang J, Yang Y, Gao Y, Zhang C, Guo X, Zhu Q, Li J, Yu L, Xu G, Fang X, Liao SG
Journal of ethnopharmacology 2025 Jan 31;340:119215

Ilex cornuta leaves extracts ameliorate hyperuricemia by modulating uric acid transporters.

Mao Y, Xu H, Xia P
Journal of ethnopharmacology 2025 Jan 10;336:118618

Multi-strategy profiling identifies limonin's dual role in gout: restoring uric acid homeostasis and suppressing inflammatory response.

Zeng M, Zhong M, Zhong X, Zhang Y, Chen X, Lin J, Zhang Y, Zheng Y, Lu J, Huang M
Food & function 2025 Dec 8;16(24):9572-9592

Urate-lowering and renal-protective effects of sugarcane polyphenols in hyperuricemia: mechanisms and key components.

Li K, Han Y, Wang Y, Zhang C, Liu W, Xi Y, Zhou Y, Li L, Li H
Food & function 2025 Aug 26;16(17):6760-6772

Prunus mume Alleviates Hyperuricemic Renal Injury: Insights From Network Pharmacology and Experimental Models.

Zheng S, Li S, Diao X, Chen N
Biomedical chromatography : BMC 2025 Apr;39(4):e70035

Chuanxiong Rhizoma extracts alleviate hyperuricaemia-induced renal injury by reducing serum UA levels and renoprotection.

Ma K, Zhou R, Yang HD, Pang XY, Li N, Song ZX, Tang ZS, Xu HB
Fitoterapia 2025 Apr;182:106456

Quercetin Prevents Hyperuricemia Associated With Gouty Arthritis by Inactivating the NLRP3/NF-κB Signaling Pathway.

Meng Q, Song C, Ma J, Cui J, Zhan J, Zhao J, Zhang Y, Zhu Z, Du X
Chemical biology & drug design 2025 Apr;105(4):e70103

Anti-inflammatory and uric acid lowering effects of Euodiae fructus on hyperuricemia and gout mice.

Wang Z, Liu J, Mou Y, Liao W, Li Y, Liu J, Tang J
Frontiers in pharmacology 2024;15:1296075

The impact of chrysanthemi indici flos-enriched flavonoid part on the model of hyperuricemia based on inhibiting synthesis and promoting excretion of uric acid.

Jiao L, Wang R, Dong Y, Su J, Yu J, Yan M, Chen S, Lv G
Journal of ethnopharmacology 2024 Oct 28;333:118488

Network Pharmacology Combined with Experimental Validation to Investigate the Mechanism of the Anti-Hyperuricemia Action of Portulaca oleracea Extract.

Zhang Y, Zhu S, Gu Y, Feng Y, Gao B
Nutrients 2024 Oct 19;16(20)

Host-derived Lactobacillus plantarum alleviates hyperuricemia by improving gut microbial community and hydrolase-mediated degradation of purine nucleosides.

Fu Y, Luo XD, Li JZ, Mo QY, Wang X, Zhao Y, Zhang YM, Luo HT, Xia DY, Ma WQ, Chen JY, Wang LH, Deng QY, Ben L, Kashif Saleemi M, Jiang XZ, Chen J, Miao K, Lin ZP, Zhang P, Ye H, Cao QY, Zhu YW, Yang L, Tu Q, Wang W
eLife 2024 Nov 7;13

Lactobacillus rhamnosus GG ameliorates hyperuricemia in a novel model.

Fu Y, Chen YS, Xia DY, Luo XD, Luo HT, Pan J, Ma WQ, Li JZ, Mo QY, Tu Q, Li MM, Zhao Y, Li Y, Huang YT, Chen ZX, Li ZJ, Bernard L, Dione M, Zhang YM, Miao K, Chen JY, Zhu SS, Ren J, Zhou LJ, Jiang XZ, Chen J, Lin ZP, Chen JP, Ye H, Cao QY, Zhu YW, Yang L, Wang X, Wang WC
NPJ biofilms and microbiomes 2024 Mar 20;10(1):25

Catalpol ameliorates fructose-induced renal inflammation by inhibiting TLR4/MyD88 signaling and uric acid reabsorption.

Chen Y, Liu Q, Meng X, Zhao L, Zheng X, Feng W
European journal of pharmacology 2024 Mar 15;967:176356

Exploration of leech therapy in treating gouty rats and its uric acid lowering mechanism.

Chao GL, Shen LX, Li P, Hua PX, Ling ML, Yuan ZY, Chuang C
Journal of Ayurveda and integrative medicine 2024 Jul-Aug;15(4):100949

Integrating multi-level interactive network and in vivo/vitro studies to explore the protective mechanism of Ampelopsis grossedentata in hyperuricemia.

Zhou QX, Zhou Q, Zhang P, Xie YQ, Yang ZY, Tan WH, Khan A, Duan WG, Zhou ZH, Liu L
Fitoterapia 2024 Jan;172:105718

Chinese Sumac (Rhus chinensis Mill.) Fruits Prevent Hyperuricemia and Uric Acid Nephropathy in Mice Fed a High-Purine Yeast Diet.

Ma N, Cai S, Sun Y, Chu C
Nutrients 2024 Jan 5;16(2)

Fuling-Zexie formula attenuates hyperuricemia-induced nephropathy and inhibits JAK2/STAT3 signaling and NLRP3 inflammasome activation in mice.

Lu M, Yin J, Xu T, Dai X, Liu T, Zhang Y, Wang S, Liu Y, Shi H, Zhang Y, Mo F, Sukhorukov V, Orekhov AN, Gao S, Wang L, Zhang D
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117262

Data mining-guided alleviation of hyperuricemia by Paeonia veitchii Lynch through inhibition of xanthine oxidase and regulation of renal urate transporters.

Du J, Wang N, Yu D, He P, Gao Y, Tu Y, Li Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Feb;124:155305

Integrated microbiome and metabolome analysis reveals the key role of taurohyocholate in the treatment of hyperuricemia with Lacticaseibacillus rhamnosus 2016SWU.05.0601.

Chen Y, Yan S, Yang J, Zhang Y, Suo H, Song J
Food research international (Ottawa, Ont.) 2024 Dec;197(Pt 1):115234

9-Hydroxy-8-oxypalmatine, a novel liver-mediated oxymetabolite of palmatine, alleviates hyperuricemia and kidney inflammation in hyperuricemic mice.

Wu X, Huang R, Ai G, Chen H, Ma X, Zhang J, Huang Q, Lao J, Zeng H, Li C, Xie J, Li Y, Su Z, Chen J, Huang X
Journal of ethnopharmacology 2024 Dec 5;335:118606

METTL14 downregulates GLUT9 through m6A methylation and attenuates hyperuricemia-induced fibrosis in mouse renal tubular epithelial cells.

Yang J, Jiang T, Lu X, Li X, Zhou X, Guo X, Ma C, Xie X, Li D, Yu S, An J, Zhao B, Li H
International immunopharmacology 2024 Dec 25;143(Pt 1):113308

Paeonia × suffruticosa Andrews leaf extract and its main component apigenin 7-O-glucoside ameliorate hyperuricemia by inhibiting xanthine oxidase activity and regulating renal urate transporters.

Zhang Y, Li Y, Li C, Zhao Y, Xu L, Ma S, Lin F, Xie Y, An J, Wang S
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Sep;118:154957

Whey protein peptides PEW and LLW synergistically ameliorate hyperuricemia and modulate gut microbiota in potassium oxonate and hypoxanthine-induced hyperuricemic rats.

Qi X, Guan K, Liu C, Chen H, Ma Y, Wang R
Journal of dairy science 2023 Nov;106(11):7367-7381

Amelioration effects of α-viniferin on hyperuricemia and hyperuricemia-induced kidney injury in mice.

Guo XL, Gao YY, Yang YX, Zhu QF, Guan HY, He X, Zhang CL, Wang Y, Xu GB, Zou SH, Wei MC, Zhang J, Zhang JJ, Liao SG
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154868

Oxyberberrubine, a novel liver microsomes-mediated secondary metabolite of berberine, alleviates hyperuricemic nephropathy in mice.

Zhong L, Lin Y, Gong S, Wu X, Liu Y, Chen J, Li Y, Yan F, Su Z, Xie Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jan;108:154521

Hypouricemic and nephroprotective effects of palmatine from Cortex Phellodendri Amurensis: A uric acid modulator targeting Keap1-Nrf2/NLRP3 axis.

Ai G, Huang R, Xie J, Zhong L, Wu X, Qin Z, Su Z, Chen J, Yang X, Dou Y
Journal of ethnopharmacology 2023 Jan 30;301:115775

Naringenin Ameliorates Hyperuricemia by Regulating Renal Uric Acid Excretion via the PI3K/AKT Signaling Pathway and Renal Inflammation through the NF-κB Signaling Pathway.

Yang B, Xin M, Liang S, Huang Y, Li J, Wang C, Liu C, Song X, Sun J, Sun W
Journal of agricultural and food chemistry 2023 Jan 25;71(3):1434-1446

Ferulic acid supplementation alleviates hyperuricemia in high-fructose/fat diet-fed rats via promoting uric acid excretion and mediating the gut microbiota.

Zhang N, Zhou J, Zhao L, Zhao Z, Wang S, Zhang L, Zhou F
Food & function 2023 Feb 6;14(3):1710-1725

The antihyperuricemia activity of Astragali Radix through regulating the expression of uric acid transporters via PI3K/Akt signalling pathway.

Zhang MQ, Sun KX, Guo X, Chen YY, Feng CY, Chen JS, Barreira JCM, Prieto MA, Sun JY, Zhang JD, Li NY, Liu C
Journal of ethnopharmacology 2023 Dec 5;317:116770

Simiao San alleviates hyperuricemia and kidney inflammation by inhibiting NLRP3 inflammasome and JAK2/STAT3 signaling in hyperuricemia mice.

Zhang Y, Wang S, Dai X, Liu T, Liu Y, Shi H, Yin J, Xu T, Zhang Y, Zhao D, Sukhorukov V, Orekhov AN, Gao S, Wang L, Zhang D
Journal of ethnopharmacology 2023 Aug 10;312:116530

Diacylated anthocyanins from purple sweet potato (Ipomoeabatatas L.) attenuate hyperglycemia and hyperuricemia in mice induced by a high-fructose/high-fat diet.

Shen L, Yang Y, Zhang J, Feng L, Zhou Q
Journal of Zhejiang University. Science. B 2023 Apr 15;24(7):587-601

Berberine Attenuates Hyperuricemia by Regulating Urate Transporters and Gut Microbiota.

Shan B, Wu M, Chen T, Tang W, Li P, Chen J
The American journal of Chinese medicine 2022;50(8):2199-2221

Therapeutic effects and mechanisms of N-(9,10-anthraquinone-2-ylcarbonyl) xanthine oxidase inhibitors on hyperuricemia.

Gao T, Xu J, Xiao Y, Li J, Hu W, Su X, Shen X, Yu W, Chen Z, Huang B, Li H, Wang X
Frontiers in pharmacology 2022;13:950699

Autophagy-dependent Na(+)-K(+)-ATPase signalling and abnormal urate reabsorption in hyperuricaemia-induced renal tubular injury.

Guan H, Lin H, Wang X, Xu Y, Zheng Y, Zhou X, Diao X, Ye Z, Xiao J
European journal of pharmacology 2022 Oct 15;932:175237

Apigenin Ameliorates Hyperuricemia and Renal Injury through Regulation of Uric Acid Metabolism and JAK2/STAT3 Signaling Pathway.

Liu T, Gao H, Zhang Y, Wang S, Lu M, Dai X, Liu Y, Shi H, Xu T, Yin J, Gao S, Wang L, Zhang D
Pharmaceuticals (Basel, Switzerland) 2022 Nov 21;15(11)

Effects of black tea and black brick tea with fungal growth on lowering uric acid levels in hyperuricemic mice.

Yuan D, Lin L, Peng Y, Zhou Y, Li L, Xiao W, Gong Z
Journal of food biochemistry 2022 Jul;46(7):e14140

Anti-Hyperuricemic and Nephroprotective Effects of Dihydroberberine in Potassium Oxonate- and Hypoxanthine-Induced Hyperuricemic Mice.

Xu L, Lin G, Yu Q, Li Q, Mai L, Cheng J, Xie J, Liu Y, Su Z, Li Y
Frontiers in pharmacology 2021;12:645879

Sonneratia apetala seed oil attenuates potassium oxonate/hypoxanthine-induced hyperuricemia and renal injury in mice.

Chen J, Xu L, Jiang L, Wu Y, Wei L, Wu X, Xiao S, Liu Y, Gao C, Cai J, Su Z
Food & function 2021 Oct 4;12(19):9416-9431

Withaferin A protects against hyperuricemia induced kidney injury and its possible mechanisms.

Zhao X, Wang J, Tang L, Li P, Ru J, Bai Y
Bioengineered 2021 Dec;12(1):589-600

Berberrubine attenuates potassium oxonate- and hypoxanthine-induced hyperuricemia by regulating urate transporters and JAK2/STAT3 signaling pathway.

Lin G, Yu Q, Xu L, Huang Z, Mai L, Jiang L, Su Z, Xie J, Li Y, Liu Y, Lin Z, Chen J
European journal of pharmacology 2021 Dec 5;912:174592

Resveratrol affects the expression of uric acid transporter by improving inflammation.

Zhang X, Nie Q, Zhang Z, Zhao J, Zhang F, Wang C, Wang X, Song G
Molecular medicine reports 2021 Aug;24(2)

Anti-hyperuricemic potential of stevia (Stevia rebaudiana Bertoni) residue extract in hyperuricemic mice.

Mehmood A, Zhao L, Ishaq M, Xin W, Zhao L, Wang C, Hossen I, Zhang H, Lian Y, Xu M
Food & function 2020 Jul 22;11(7):6387-6406

MiR-143-3p directly targets GLUT9 to reduce uric acid reabsorption and inflammatory response of renal tubular epithelial cells.

Zhou Z, Dong Y, Zhou H, Liu J, Zhao W
Biochemical and biophysical research communications 2019 Sep 24;517(3):413-420

Conjugated Linoleic Acid Ameliorates High Fructose-Induced Hyperuricemia and Renal Inflammation in Rats via NLRP3 Inflammasome and TLR4 Signaling Pathway.

Tan J, Wan L, Chen X, Li X, Hao X, Li X, Li J, Ding H
Molecular nutrition & food research 2019 Jun;63(12):e1801402

Impaired Na(+)-K(+)-ATPase signaling in renal proximal tubule contributes to hyperuricemia-induced renal tubular injury.

Xiao J, Zhang X, Fu C, Yang Q, Xie Y, Zhang Z, Ye Z
Experimental & molecular medicine 2018 Mar 2;50(3):e452

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