135607

antibody from BioLegend
Targeting: CD276 B7-H3, B7H3, B7RP-2
Provider product page for 135607

Antibody data

Product number
135607 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#135607, RRID:AB_2566062
Product name
APC anti-mouse/human CD276 (B7-H3)
Antibody type
Monoclonal
Antigen
Mouse B7-H3 transfected L cell and P815
Description
B7-H3 is a type I transmembrane protein belonging to the B7 family of co-stimulatory proteins. B7-H3 is mostly expressed on professional APCs including B cells, macrophages, and dendritic cells at low levels. It is detected on various human and murine tumor cells, nasal and airway epithelial cells. Its expression on dendritic cells appears to be up-regulated by LPS. Initial studies have shown that B7-H3 provides a stimulatory signal to T cells. However, recent studies suggest a negative regulatory role for B7-H3 in T cell responses. Mouse B7-H3 protein inhibited T cell activation and effector cytokine production. Thus, the immunological function of B7-H3 remains unclear. B7-H3 is involved in the suppression of Th1-mediated immune responses and plays an important role in the development of pathogenic Th2 cells in a murine asthma model. Monoclonal antibody against B7-H3 enhances T cell proliferation in vitro and leads to exacerbated EAE in vivo. It has been reported that the Triggering Receptor Expressed on Myeloid cells (TREM)-like Transcript 2 (TLT-2, TREML2) is a receptor for B7-H3 in mice, although it remains controversial. Further studies are needed to identify the receptor of B7-H3.
Reactivity
Human, Mouse
Host
Rat
Conjugate
Red dye
Antibody clone number
MIH35
Vial size
25 µg
Concentration
0.2 mg/ml
Storage
2°C-8°C
Handling
Ambient RT
CD276 protein structure - 135607 shown in red.