AGTO-G007E

antibody from Creative Biolabs

Targeting: CD276 B7-H3, B7H3, B7RP-2

Functional assay (Recommended by provider)

Antibody Data

Product number

AGTO-G007E

Provider

Creative Biolabs

Product name

Anti-CD276 immunotoxin 8H9 (scFv)-PE

Antibody type

Monoclonal

Description

This immunotoxin was achieved by conjugating/fusing the Anti-CD276 scFv to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively bind to a cell surface glycoprotein expressed on human breast cancers; childhood sarcomas; and neuroblastomas. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treating human breast cancers; childhood sarcomas and neuroblastomas.

Reactivity

Human

Host

Mouse

Antibody clone number

8H9