66481-1-Ig

antibody from Proteintech Group

Targeting: CD276 B7-H3, B7H3, B7RP-2

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Flow cytometry (Data presented on provider website)

Antibody Data

Product number

66481-1-Ig

Provider

Proteintech Group

Product name

B7-H3 antibody

Antibody type

Monoclonal

Description

KD/KO validated B7-H3 antibody (Cat. #66481-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human, Pig and has been validated for the following applications: FC, IF, IHC, WB,ELISA.

Reactivity

Human, Porcine

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

1E7D1

Vial size

20ul, 150ul

References

Submitted references

CD276 promotes CD36-mediated lipid metabolism and confers resistance to tyrosine kinase inhibitors.

Huang X, Ma L, Lu Y, Cui J, Qi W, Song J, Guo J, Wang S, Fang J, Lu Z, Qiu W
Cancer letters 2026 Jul 10;650:218492

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Palmitic acid-triggered B7H3 palmitoylation promotes immune escape.

Rao Z, Huang C, Wu Q, Li M, Liu A, Zhu T, Yang W, Yin L, Zhu S, She X, Yu C, Liu L, Li P, Bai Y, Zhang D, Xie T, Liu X, Liu L, Xu F, Wang G, Hu J, Luo X
Nature communications 2026 Jan 19;17(1):1810

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Multiomic analysis of colorectal adenocarcinoma reveals a new subtype of myofibroblastic cancer-associated fibroblasts that express high levels of B7-H3 and have poor-prognosis value.

Picard M, Guille A, Finetti P, De Rauglaudre B, Belfil N, Mescam L, Birnbaum DJ, Bertucci F, Mamessier E
Journal for immunotherapy of cancer 2026 Feb 2;14(2)

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Zinc finger protein ZC3H18 is abnormally expressed in esophageal cancer tissues and facilitates the proliferation of esophageal cancer cells.

Zhang Y, Wan Y, Li J, Ju S, Tong X, Wu J, Wu H, Zhang L, Shao S, Wang Y, Guo L, Zhao J, Cao L, Jiang D
Frontiers in immunology 2025;16:1556509

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EPB41L3 as a prognostic biomarker suppressing cellular malignancy and correlating with the immune microenvironment in glioma.

Liu X, Liu Y, Du K, Wang C, Zhang Y, Li L, Wang D, Chen L, Nov P, Li J, Zeng R
Biochemical and biophysical research communications 2025 Sep 8;778:152305

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Expression of antibody-drug conjugate targets in soft tissue sarcomas.

Bertucci F, Finetti P, Mescam L, Monneur A, Frejafon A, Le Cesne A, Treilleux I, Italiano A, Brahmi M, Blay JY, Mamessier E
ESMO open 2025 Oct;10(10):105837

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Development of a bispecific antibody that inhibits EGFR and B7H3 in NSCLC.

Zhi X, Wang J, Guo J, Luo L, Sun H, Li Y, Zhao Z, Wang C, Zhu L, Li X, Wang F, Li F, Yu K, Ren S
Biomarker research 2025 Nov 25;13(1):158

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B7-H3 and CD39 Co-Localization in Gastric Cancer: A Potential Prognostic Biomarker and Potential Dual-Target for Immunotherapy.

Zhang Q, Liu Y, Xuan H, Zhan S, Shen Y, Wang R, Chen S, Ding S, Liu C, Huang L, Ma Q, Jiang T, Cao L
Technology in cancer research & treatment 2025 Jan-Dec;24:15330338251380957

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Improving Targeted Delivery and Antitumor Efficacy of TRAIL through Fusion with a B7H3-Antagonistic Affibody.

Lu X, Zhan X, Xia G, Wang F, Lv M, Liu R, Liu Y, Zi C, Li G, Wang R, Li J, Yuan F, Jia D
Molecular pharmaceutics 2025 Jan 6;22(1):284-294

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Neoadjuvant immunochemotherapy improves clinical outcomes of patients with esophageal cancer by mediating anti-tumor immunity of CD8+ T (Tc1) and CD16+ NK cells.

He Y, Yang D, Lin X, Zhang J, Cheng R, Cao L, Yang L, Zhang M, Shi X, Jin X, Sun H, Sun H, Zang J, Li Y, Ma J, Nie H
Frontiers in immunology 2024;15:1412693

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Expression of B7-H3 and B7-H4 in Gastric Gastrointestinal Stromal Tumors.

Mochizuki K, Oishi N, Tahara I, Inoue T, Kondo T
Applied immunohistochemistry & molecular morphology : AIMM 2024 Nov-Dec 01;32(10):484-487

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Engineered oncolytic virus expressing B7H3-targeting BiTE enhances antitumor T-cell immune response.

Zhu H, Zhang W, Guo Q, Fan R, Luo G, Liu Y
Journal for immunotherapy of cancer 2024 Nov 29;12(11)

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Comprehensive Analysis Reveals Distinct Immunological and Prognostic Characteristics of CD276/B7-H3 in Pan-Cancer.

Ding J, Sun Y, Sulaiman Z, Li C, Cheng Z, Liu S
International journal of general medicine 2023;16:367-391

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Enhancement of CAR-T cell activity against cholangiocarcinoma by simultaneous knockdown of six inhibitory membrane proteins.

Qiao Y, Chen J, Wang X, Yan S, Tan J, Xia B, Chen Y, Lin K, Zou F, Liu B, He X, Zhang Y, Zhang X, Zhang H, Wu X, Lu L
Cancer communications (London, England) 2023 Jul;43(7):788-807

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B7-H3 and CD47 co-expression in gastric cancer is a predictor of poor prognosis and potential targets for future dual-targeting immunotherapy.

Chen S, Zhan S, Ding S, Zhang Q, Xuan H, Zhang X, Cao L
Journal of cancer research and clinical oncology 2023 Dec;149(18):16609-16621

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Genome-scale CRISPR-Cas9 screen reveals novel regulators of B7-H3 in tumor cells.

Zhao S, Wang Y, Yang N, Mu M, Wu Z, Li H, Tang X, Zhong K, Zhang Z, Huang C, Cao T, Zheng M, Wang G, Nie C, Yang H, Guo G, Zhou L, Zheng X, Tong A
Journal for immunotherapy of cancer 2022 Jun;10(6)

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An N-glycoproteomic site-mapping analysis reveals glycoprotein alterations in esophageal squamous cell carcinoma.

Gao Y, Shen L, Dong T, Yang X, Cui H, Guo Y, Ma Y, Kong P, Cheng X, Zhang L, Cui Y
Journal of translational medicine 2022 Jun 25;20(1):285

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TROP-2, Nectin-4, GPNMB, and B7-H3 Are Potentially Therapeutic Targets for Anaplastic Thyroid Carcinoma.

Toda S, Sato S, Saito N, Sekihara K, Matsui A, Murayama D, Nakayama H, Suganuma N, Okubo Y, Hayashi H, Iwasaki H, Miyagi Y, Hoshino D
Cancers 2022 Jan 24;14(3)

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B7-H3 inhibits apoptosis of gastric cancer cell by interacting with Fibronectin.

Sun M, Xie J, Zhang D, Chen C, Lin S, Chen Y, Zhang G
Journal of Cancer 2021;12(24):7518-7526

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Fibronectin enhances tumor metastasis through B7-H3 in clear cell renal cell carcinoma.

Xie J, Sun M, Zhang D, Chen C, Lin S, Zhang G
FEBS open bio 2021 Nov;11(11):2977-2987