Antibody data
- Antibody Data
- Antigen structure
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- Product number
- 331602 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#331602, RRID:AB_1279202
- Product name
- Purified anti-human CD276 (B7-H3)
- Antibody type
- Monoclonal
- Antigen
- CD276 (B7-H3)
- Description
- B7-H3 is a member of the B7 gene family. It has 88% amino acid sequence identity with mouse B7-H3. It is mostly expressed on professional APCs, including B cells, macrophages, and dendritic cells. Its expression on dendritic cells appears to be up-regulated by LPS. B7-H3 protein inhibits T cell activation and cytokine production. It was reported that monoclonal antibody against B7-H3 enhanced T cell proliferation in vitro and led to exacerbated EAE in vivo. Therefore, B7-H3 may be a negative regulator on T cell activation and function.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- The antibody solution should be stored undiluted at 4 °C.
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