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- References [24]
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- Product number
- 12545-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12545-1-AP, RRID:AB_2268102
- Product name
- PEX5 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PEX5 antibody (Cat. #12545-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Peroxisomal integrity in demyelination-associated microglia enables cellular debris clearance and myelin renewal in mice.
Single-nucleus RNA sequencing and functional studies of acute methamphetamine-induced cognitive impairment.
TRIM37-mediated stabilization of PEX5 via monoubiquitination attenuates oxidative stress and demyelination in multiple sclerosis insights from EAE and LPC-induced experimental models.
SIRT5-mediated desuccinylation of the porcine deltacoronavirus M protein drives pexophagy to enhance viral proliferation.
Bacterial pathogens hijack host cell peroxisomes for replication vacuole expansion and integrity.
FAF2 is a bifunctional regulator of peroxisomal homeostasis and saturated lipid responses.
Salmonella Typhimurium effector SseI regulates host peroxisomal dynamics to acquire lysosomal cholesterol.
PPARβ/δ Activation Improves Corticosterone-Induced Oxidative Stress Damage in Astrocytes by Targeting UBR5/ATM Signaling.
PEX11B palmitoylation couples peroxisomal dysfunction with Schwann cells fail in diabetic neuropathy.
The p97-UBXD8 complex maintains peroxisome abundance by suppressing pexophagy.
Polymorphism in the Hsa-miR-4274 seed region influences the expression of PEX5 and enhances radiotherapy resistance in colorectal cancer.
Dietary cysteine and methionine promote peroxisome elevation and fat loss by induction of CG33474 expression in Drosophila adipose tissue.
Hepatitis C virus alters the morphology and function of peroxisomes.
Comparison of human PEX knockout cell lines suggests a dual role of PEX1 in peroxisome biogenesis.
Circular RNA Sec61 subunit alpha isoform 1 by competitive absorption of microRNA-513a-5p mediates peroxisomal biogenesis factor 5 expression and promotes the malignant phenotype of non-small cell lung cancer.
Silencing PEX26 as an unconventional mode to kill drug-resistant cancer cells and forestall drug resistance.
PEX5 prevents cardiomyocyte hypertrophy via suppressing the redox-sensitive signaling pathways MAPKs and STAT3.
Pkd1 Mutation Has No Apparent Effects on Peroxisome Structure or Lipid Metabolism.
Resolving monocytes generated through TRAM deletion attenuate atherosclerosis.
Aging lowers PEX5 levels in cortical neurons in male and female mouse brains.
Ceramide regulates interaction of Hsd17b4 with Pex5 and function of peroxisomes.
ATM functions at the peroxisome to induce pexophagy in response to ROS.
A novel type of rhizomelic chondrodysplasia punctata, RCDP5, is caused by loss of the PEX5 long isoform.
A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS.
Barnes-Vélez JA, Zhang X, Peña Señeriz YL, Scott KA, Guan Y, Hu J
The Journal of clinical investigation 2026 Jan 2;136(1)
The Journal of clinical investigation 2026 Jan 2;136(1)
Single-nucleus RNA sequencing and functional studies of acute methamphetamine-induced cognitive impairment.
An D, Lu F, Wang Y, Zhang Z, Meng S, Chen Y, You X, Zhu Y, Yuan W, Zhou Z, Huang P, Wang J, Chen X
Communications biology 2026 Feb 16;9(1)
Communications biology 2026 Feb 16;9(1)
TRIM37-mediated stabilization of PEX5 via monoubiquitination attenuates oxidative stress and demyelination in multiple sclerosis insights from EAE and LPC-induced experimental models.
Jiang L, Jin Y, Han Y, Fu J
PloS one 2025;20(10):e0335198
PloS one 2025;20(10):e0335198
SIRT5-mediated desuccinylation of the porcine deltacoronavirus M protein drives pexophagy to enhance viral proliferation.
Li Z, Tang W, Lai Y, Chen C, Fang P, Zhou Y, Fang L, Xiao S
PLoS pathogens 2025 May;21(5):e1013163
PLoS pathogens 2025 May;21(5):e1013163
Bacterial pathogens hijack host cell peroxisomes for replication vacuole expansion and integrity.
Hossain MJ, Romanov KA, Jian J, Swaby LC, Bandyopadhyay S, Guan I, Thomas SM, Olive AJ, O'Connor TJ
Science advances 2025 May 2;11(18):eadr8005
Science advances 2025 May 2;11(18):eadr8005
FAF2 is a bifunctional regulator of peroxisomal homeostasis and saturated lipid responses.
Kim C, Gabriel KR, Boone D, Brown MR, Oppenheimer K, Kost-Alimova M, Pablo JLB, Greka A
Science advances 2025 Jul 4;11(27):eadu9104
Science advances 2025 Jul 4;11(27):eadu9104
Salmonella Typhimurium effector SseI regulates host peroxisomal dynamics to acquire lysosomal cholesterol.
Raj D, Nair AV, Singh A, Basu S, Sarkar K, Sharma J, Sharma S, Sharma S, Rathore M, Singh S, Prakash S, Simran, Sahu S, Kaushik AC, Siddiqi MI, Ghoshal UC, Chandra T, Bhosale V, Dasgupta A, Gupta SK, Verma S, Guha R, Chakravortty D, Ammanathan V, Lahiri A
EMBO reports 2025 Feb;26(3):656-689
EMBO reports 2025 Feb;26(3):656-689
PPARβ/δ Activation Improves Corticosterone-Induced Oxidative Stress Damage in Astrocytes by Targeting UBR5/ATM Signaling.
Ji J, Chen YF, Hong C, Ren XW, Xu H, Cai ZY, Dong YF, Sun XL
Journal of neurochemistry 2025 Feb;169(2):e70013
Journal of neurochemistry 2025 Feb;169(2):e70013
PEX11B palmitoylation couples peroxisomal dysfunction with Schwann cells fail in diabetic neuropathy.
Yang YM, Ma HB, Xiong Y, Wu Q, Gao XK
Journal of biomedical science 2025 Feb 12;32(1):20
Journal of biomedical science 2025 Feb 12;32(1):20
The p97-UBXD8 complex maintains peroxisome abundance by suppressing pexophagy.
Montes ID, Amirthagunanathan S, Joshi AS, Raman M
bioRxiv : the preprint server for biology 2024 Sep 26;
bioRxiv : the preprint server for biology 2024 Sep 26;
Polymorphism in the Hsa-miR-4274 seed region influences the expression of PEX5 and enhances radiotherapy resistance in colorectal cancer.
Lu Q, Ren N, Chen H, Zhang S, Yan R, Li M, Zheng L, Tan W, Lin D
Frontiers of medicine 2024 Oct;18(5):921-937
Frontiers of medicine 2024 Oct;18(5):921-937
Dietary cysteine and methionine promote peroxisome elevation and fat loss by induction of CG33474 expression in Drosophila adipose tissue.
Liu M, He L
Cellular and molecular life sciences : CMLS 2024 Apr 22;81(1):190
Cellular and molecular life sciences : CMLS 2024 Apr 22;81(1):190
Hepatitis C virus alters the morphology and function of peroxisomes.
Martin de Fourchambault E, Callens N, Saliou JM, Fourcot M, Delos O, Barois N, Thorel Q, Ramirez S, Bukh J, Cocquerel L, Bertrand-Michel J, Marot G, Sebti Y, Dubuisson J, Rouillé Y
Frontiers in microbiology 2023;14:1254728
Frontiers in microbiology 2023;14:1254728
Comparison of human PEX knockout cell lines suggests a dual role of PEX1 in peroxisome biogenesis.
Ott J, Sehr J, Schmidt N, Schliebs W, Erdmann R
Biological chemistry 2023 Feb 23;404(2-3):209-219
Biological chemistry 2023 Feb 23;404(2-3):209-219
Circular RNA Sec61 subunit alpha isoform 1 by competitive absorption of microRNA-513a-5p mediates peroxisomal biogenesis factor 5 expression and promotes the malignant phenotype of non-small cell lung cancer.
Duan ZP, Yu XJ, Wei HL
The Kaohsiung journal of medical sciences 2023 Apr;39(4):326-336
The Kaohsiung journal of medical sciences 2023 Apr;39(4):326-336
Silencing PEX26 as an unconventional mode to kill drug-resistant cancer cells and forestall drug resistance.
Dahabieh MS, Huang F, Goncalves C, Flores González RE, Prabhu S, Bolt A, Di Pietro E, Khoury E, Heath J, Xu ZY, Rémy-Sarrazin J, Mann KK, Orthwein A, Boisvert FM, Braverman N, Miller WH, Del Rincón SV
Autophagy 2022 Mar;18(3):540-558
Autophagy 2022 Mar;18(3):540-558
PEX5 prevents cardiomyocyte hypertrophy via suppressing the redox-sensitive signaling pathways MAPKs and STAT3.
Wang M, Li J, Ding Y, Cai S, Li Z, Liu P
European journal of pharmacology 2021 Sep 5;906:174283
European journal of pharmacology 2021 Sep 5;906:174283
Pkd1 Mutation Has No Apparent Effects on Peroxisome Structure or Lipid Metabolism.
Terabayashi T, Menezes LF, Zhou F, Cai H, Walter PJ, Garraffo HM, Germino GG
Kidney360 2021 Oct 28;2(10):1576-1591
Kidney360 2021 Oct 28;2(10):1576-1591
Resolving monocytes generated through TRAM deletion attenuate atherosclerosis.
Geng S, Zhang Y, Yi Z, Lu R, Li L
JCI insight 2021 Oct 22;6(20)
JCI insight 2021 Oct 22;6(20)
Aging lowers PEX5 levels in cortical neurons in male and female mouse brains.
Uzor NE, Scheihing DM, Kim GS, Moruno-Manchon JF, Zhu L, Reynolds CR, Stephenson JM, Holmes A, McCullough LD, Tsvetkov AS
Molecular and cellular neurosciences 2020 Sep;107:103536
Molecular and cellular neurosciences 2020 Sep;107:103536
Ceramide regulates interaction of Hsd17b4 with Pex5 and function of peroxisomes.
Zhu Z, Chen J, Wang G, Elsherbini A, Zhong L, Jiang X, Qin H, Tripathi P, Zhi W, Spassieva SD, Morris AJ, Bieberich E
Biochimica et biophysica acta. Molecular and cell biology of lipids 2019 Oct;1864(10):1514-1524
Biochimica et biophysica acta. Molecular and cell biology of lipids 2019 Oct;1864(10):1514-1524
ATM functions at the peroxisome to induce pexophagy in response to ROS.
Zhang J, Tripathi DN, Jing J, Alexander A, Kim J, Powell RT, Dere R, Tait-Mulder J, Lee JH, Paull TT, Pandita RK, Charaka VK, Pandita TK, Kastan MB, Walker CL
Nature cell biology 2015 Oct;17(10):1259-1269
Nature cell biology 2015 Oct;17(10):1259-1269
A novel type of rhizomelic chondrodysplasia punctata, RCDP5, is caused by loss of the PEX5 long isoform.
Barøy T, Koster J, Strømme P, Ebberink MS, Misceo D, Ferdinandusse S, Holmgren A, Hughes T, Merckoll E, Westvik J, Woldseth B, Walter J, Wood N, Tvedt B, Stadskleiv K, Wanders RJ, Waterham HR, Frengen E
Human molecular genetics 2015 Oct 15;24(20):5845-54
Human molecular genetics 2015 Oct 15;24(20):5845-54
A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS.
Zhang J, Kim J, Alexander A, Cai S, Tripathi DN, Dere R, Tee AR, Tait-Mulder J, Di Nardo A, Han JM, Kwiatkowski E, Dunlop EA, Dodd KM, Folkerth RD, Faust PL, Kastan MB, Sahin M, Walker CL
Nature cell biology 2013 Oct;15(10):1186-96
Nature cell biology 2013 Oct;15(10):1186-96
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PEX5 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PEX5. This antibody recognizes human, mouse, rat antigen. The PEX5 antibody has been validated for the following applications: ELISA, WB analysis.
